Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Combretastatins"”.
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Synthesis and evaluation of novel antivascular agents for two-photon activation
… treatments to combat this disease is important. Combretastatins are powerful anticancer drugs with some derivatives in advanced clinical trials for cancer therapy. Combretastatins are stilbenes isolated from the African shrub Combretum caffrum. These agents interact with tubulin in a similar way …
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Two-Photon Microscopy of E-Combretastatin uptake and activation in live mammalian cells
… modalities to combat this disease is important.Combretastatins are powerful anticancer drugs that are being evaluated in phase I/II clinicaltrials. Combretastatins act by binding to p-tubulin, preventing microtubule assembly andinhibiting angiogenesis in developing tumours. Most widely studied …
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Synthesis and evaluation of tetramethoxy stilbenes related to combretastatin A-4 as potential anticancer agents
… display less toxicity (Ali et al., 2012). Combretastatins are known to have cytotoxic activity against cancer cells with minimal side effects (Kretzschmann & Fürst, 2013). Derivatives with improved activity and less detrimental side effects are required. The different activities of …
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Design and synthesis of dihydronaphthalene vascular disrupting agents and indolequinone-based bioreductives.
… show great promise. The naturally occurring combretastatins, especially combretastatin A-4 (CA4) and combretastatin A-1 (CA1), in suitable prodrug form, have proven to be highly effective VDAs. In this study, efforts were directed towards the synthesis of two combretastatin analogs bearing …