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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Combinatorial Libraries"”.
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Cell Targeted Ribosome Inactivating Proteins Derived from Protein Combinatorial Libraries
Combinatorial protein libraries based on a protein template offer a vast potential for deriving protein variants harboring new receptor specificity while retaining other tem-plate functions to serve as library search-engines, cell-routing sequences and therapeutic domains. This concept was tested …
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Novel Photochemical Methodologies for Diversity Oriented Synthesis and Screening of Combinatorial Libraries
… to the encoding and screening of solution phase libraries based on the photorelease of externally sensitized photolabile tags. The encoding tags can be released into solution only when a binding event occurs between the ligand and the receptor, equipped with an electron transfer sensitizer. The …
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Development of microanalysis tools for characterization of the humoral response to infections diseases
… antibody repertoires or by filtering through combinatorial libraries of human variable genes using display technologies. Combinatorial libraries of human variable genes afford the flexibility to pursue many targets of interest, but often result in the selection of low affinity antibodies or …
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Strategies for combinatorial development of siRNA conjugate delivery systems
… performance has relied heavily on studies using combinatorial synthesis and high-throughput screening of large libraries to discover novel delivery materials. Conjugate delivery systems are attractive for their purity, well-defined structures, low ratios of delivery material to siRNA, and …
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Building a Genetic System in Yeast to Search for High Affinity Proteins in Sequence Space
… binders, and test these systems on simple loop libraries. In Chapter 3, I construct a genetic system in yeast that can mutate a protein loop via homologous recombination, and test its recombination function. In Chapter 4, I mate libraries that target two different loops, and run FACS on the …
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Electroorganic synthesis in microreactors
… interested in the high throughput synthesis of combinatorial libraries for pharmaceutical evaluation. Furthermore, techniques such as electrochemical synthesis may be used to prepare chemicals, which are difficult to prepare by conventional techniques.The main aim of this research project was to …
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An in vitro evaluation of tyrosine derived polyarylates and polycarbonate as polymeric scaffold for human mesenchymal stem cells osteogenic differentiation
… scaffolds. Polycarbonates and polyarylates have combinatorial libraries that exhibit a range of surface chemistries leading to changes in the surface properties such as wettability, rigidity and protein adsorption. Structural modifications of their pendant chain and backbone provide a means to …
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Synthetic coenzymes for in vitro selection of DNA enzymes.
… (deoxyribozymes) have been isolated from combinatorial libraries (pools) of randomized oligonucleotides. These enzyme-like DNAs customarily utilize divalent metal ions as cofactors in their catalysis. The metal ion cofactors are important because they can participate in both the correct …
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A combinatorial approach to the chemical synthesis and biological evaluation of 3,4,5-trisubstiituted furan-2(5H)-ones
… this molecule lends itself to manipulation using combinatorial techniques due to the presence of more than one site for the attachment of different suhstituents. By developing different reaction schemes at the three sites available for attachment on the furan-2(5H)-one scaffold, combinatorial …
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Synthesis and Combinatorial Optimization of Novel Star-Shaped Resist Materials for Lithographic Applications
… development of new resist materials and their combinatorial investigation concerning the performance in lithographic patterning. The lithographic patterning procedure is a sequence of multiple processing steps and thus this procedure involves many processing variables interacting strongly with …
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Controlling Gene Expression with Synthetic Molecules
… screening and characterization of large peptoid libraries has been developed. Peptoids are a new class of peptidomimetic compounds that are resistant to proteolytic cleavage and are relatively simple and cheap to synthesize. One of the combinatorial libraries was screened against CBP …
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Functional DNA Aptamers as Biotherapeutic Molecules
… and specificity. Aptamers are derived using combinatorial libraries comprised of a variable region flanked by two primer regions used for a process termed Systematic Evolution of Ligands by Exponential Enrichment (SELEX). The central theme of my thesis was to use this technology to develop …
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Combinatorial Polymer Synthesis and High-Throughput Screening Technology to Identify Optimal Approaches for Mineralized Tissue Engineering
… iterative steps. However, recent advances in combinatorial chemistry and high through-put screening (HTS) technology have made available a wider range of potential scaffold materials with diverse properties, as well as new methods to accelerate the process of testing soluble factors or …
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Synthesis and Structure Activity Relationship Studies of a Natural Product-Derived Compound Library
… focus on the production of large chemical libraries by combinatorial synthesis. While hundreds of thousands of compounds have been made in this way, only one FDA approved drug has been made by de novo synthesis. Compounds made by combinatorial methods lack much of the complexity afforded by …
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Synthesis and Structure Activity Relationship Studies of a Natural Product-Derived Compound Library
… focus on the production of large chemical libraries by combinatorial synthesis. While hundreds of thousands of compounds have been made in this way, only one FDA approved drug has been made by de novo synthesis. Compounds made by combinatorial methods lack much of the complexity afforded by …
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Exploration of Toll-like Receptor 7 and 8 Agonists as Potential Vaccine Adjuvants
… proinflammatory cytokine induction (Chapter 3). Combinatorial libraries using the Groebke-Blackburn-Bienaymé reaction have also yielded TLR7/8-inactive, but antibacterial imidazo[1,2-a]pyridines (Chapter 4). Based on the previously reported SARs on imidazoquinolines, the syntheses and biological …
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Pin1 Catalytic and WW Domain Ligands
… of L-Ser and L-Pip, to improve the affinity. Combinatorial chemistry is a powerful method to discover biologically active compounds, and solid-phase synthesis is most commonly used to synthesize combinatorial libraries. To identify ligands for the Pin1 WW domain, a library, R1CO–pSer–Pro–NHR2, …
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Molecular Interactions of Human C9: The Pore Forming Protein of the Complement System
… accomplishing this goal: commercially available combinatorial libraries and a custom library containing peptides from the MACPF domain of C9.</p> <p>The second aim was to identify covalent bond rearrangement within poly C9. Poly C9 is remarkably resistant to denaturation and proteolysis. …
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Pathway engineering for the discovery and optimized production of phosphonic acids
… that allows one to home in on top pathways in combinatorial libraries. When applied to the FR900098 pathway, a strain with a significant increase in production was found. This method can also be applied to other natural product pathways to rapidly find expression configurations that give higher …
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Study of peptide-mineral interactions
… of peptides/motifs (hiomolecules) isolated from combinatorial libraries for silica and ZnO synthesis has been shown to he a promising approach for morphology and reaction control. It is particularly exciting when their use can he extended to the generation of ZnO which has non-biological origin. …
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