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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Combinatorial Chemistry"”.
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The activated core approach to combinatorial chemistry
… Institute of Technology, Dept. of Chemistry, 1999.
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Solid-phase combinatorial chemistry and scintillation proximity assays
… were used successfully both in solid-phase combinatorial synthesis of a peptide nucleic acid (PNA)-library and subsequent screening of this library for the ability to hybridise with DNA, which was labelled with a suitable radio-isotape. This data was used to identify the dependence of the …
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The impact of combinatorial chemistry on the pharmaceutical drug discovery process
Thesis (M.S.)--Massachusetts Institute of Technology, Sloan School of Management, 1995.
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Solution-phase combinatorial chemistry--the activated core approach ; II. Porphyrin-based small molecule receptors
… Institute of Technology, Dept. of Chemistry, 1997.
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Optimization of chemical reagent storage and distribution at Novartis Institutes for BioMedical Research
… many of its peers, Novartis relies strongly on combinatorial chemistry to populate its screening deck. The Chemical Libraries (CLI) group is responsible for this approach at Novartis and delivers more than 100,000 compounds per year to the Novartis Compound Archive. Since the introduction of …
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Probabilistic modeling of the drug development domain: A Bayesian domain-knowledge application for pharmacovigilance
… in the number of putative NCEs as a result of combinatorial chemistry and high-throughput screening has only confounded this problem by significantly increasing the number of early-phase NCEs under consideration for further costly development in human clinical trials. It is widely agreed upon …
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A combinatorial approach to the chemical synthesis and biological evaluation of 3,4,5-trisubstiituted furan-2(5H)-ones
… this molecule lends itself to manipulation using combinatorial techniques due to the presence of more than one site for the attachment of different suhstituents. By developing different reaction schemes at the three sites available for attachment on the furan-2(5H)-one scaffold, combinatorial …
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Development and analysis of a gravity-simulated particle-packing algorithm for modeling optimized rocket propellants
… This was intended to be fast for use in combinatorial chemistry applications and to provide a numerical representation of the material for use with other computational tools, including codes that predict combustion behavior. The packing algorithms were evaluated using homogeneous …
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Using human metabolic enzyme profiling as an innovative technology in the drug development process
… of numerous compounds generated through combinatorial chemistry and high-throughput pharmacological screening. The integration of these technologies into the drug development process will significantly reduce the dropout risks in clinical trials and shorten the period between the drug …
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Algorithms for improving the design and production of oligonucleotide microarrays
… nucleotide-by-nucleotide, by a light-directed combinatorial chemistry. Because of the natural properties of light, the quality of a microarray can be compromised if the physical arrangement of the probes on the array and their synthesis schedule are not carefully designed. This thesis is mainly …
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Dynamic combinatorial synthesis of donor-acceptor catenanes
Dynamic combinatorial chemistry (DCC) is a powerful method for synthesising complex molecules and identifying unexpected receptors. Chapter 1 gives an overview of the concept of DCC and its applications, and discusses its evolution to date. Chapter 2 describes the discovery of a new generation of …
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Biosynthetic engineering for the assembly of better drugs
… turn, stems from the industry's persistence with combinatorial chemistry to synthesize drug candidates. Not only is the chemical space being screened for biological activity usually one that has been previously interrogated, but the products of combinatorial chemistry too are simply not drug-like. …
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Evaluation of Phenomena that Determine the Performance of Immunoaffinity, Peptide-Based and Ion Exchange Affinity Sorbents
… are one of the newest technologies arising from combinatorial chemistry with applications to the difficult problem of purifying high-molecular weight proteins from complex mixtures. Two types of structural motifs which are common to small peptide affinity ligands derived from combinatorial …
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Integration of freestanding polyelectrolyte multilayer membranes in larger scale structures
… capsules were created. These can be useful for combinatorial chemistry or sensing. This concept was expanded to couple encapsulated living cells to the surface. The second concept is the transfer of flat freestanding multilayer membranes to structured surfaces. We have developed a method that …
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Tools to analyse cell signaling models
… high-throughput techniques such as gene-chips, combinatorial chemistry, and fast gene sequencing. The goal of computational biology is to use quantitative models to test complex scientific hypotheses or predict desirable interventions. Consequently, it is important that the model is built to the …
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Towards novel luminescent probes for monitoring β- galactosidase activity
… suitable substrates for the enzyme, a dynamic combinatorial chemistry approach was also explored. This used disulfide bonds to attach the naphthyl moiety to the methyl glucoside using linkers of different lengths. From this library, the enzyme successfully processed the novel disulfide …
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Synthesis and biological evaluation of potential anti-cancer agents
The new technology of combinational chemistry has been introduced to pharmaceutical companies, improving and making more efficient the process of drug discovery. Automated combinatorial chemistry in the solution-phase has been used to prepare a large number of compounds of anti-cancer screening. A …
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