Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"Combination therapies"”.
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Effects of combination therapies on age-related macular degeneration
… of more effective treatments by combining these therapies is being tested through clinical trials. Studies of combined PDT and anti-VEGF, combined PDT and steroids, and anti-VEGF monotherapy were reviewed, comparing changes in average visual acuity, foveal thickness, and number of injections …
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Inferring effective cancer combination therapies using network-based multi-omics data integration
… to monotherapy-based interventions. Drug combination therapies hold the promise of higher efficacy by simultaneously targeting compensatory mechanisms in tumours and reducing toxicity through the use of lower drug doses. However, identifying effective combination therapies and the …
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CRISPRi screens to identify combination therapies for the improved treatment of ovarian cancer
… consists of surgical debulking followed by a combination of platinum and taxane agents, but relapse and resistance frequently occur. To identify genes that confer sensitivity or resistance in tumor cells treated with platinum chemotherapeutics, I performed genome-wide screens combining …
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Identifying and Targeting Molecular Deregulations In Uterine Leiomyosarcoma: A Role For Mtor Inhibition-Based Combination Therapies
… <em>in vivo</em>. Given that effective mTOR therapies likely require combination mTOR blockade with inhibition of other targets, coupled with recent observations suggesting that Aurora A kinase (Aurk A) deregulations commonly occur in ULMS, the preclinical impact of dually targeting both …
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A Study of Cellular Amino Acid Homeostasis Identifies Novel Targets, Inhibitors and Combination Therapies in Cancer
Amino acid homeostasis is maintained by a combination of transmembrane transport processes, metabolic pathways, protein synthesis and turnover, and signalling systems to furnish cells, tissues, organs, and organisms with optimal levels of these nutrients. Understanding how these elements support …
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A Study of Cellular Amino Acid Homeostasis Identifies Novel Targets, Inhibitors and Combination Therapies in Cancer
Amino acid homeostasis is maintained by a combination of transmembrane transport processes, metabolic pathways, protein synthesis and turnover, and signalling systems to furnish cells, tissues, organs, and organisms with optimal levels of these nutrients. Understanding how these elements support …
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TARGETING CANCER METABOLISM WITH FASTING-MIMICKING DIET¿BASED LOW-TOXIC COMBINATION THERAPIES: OVERCOMING RESISTANCE THROUGH METABOLIC SYNERGY
… oncogene are particularly resistant to targeted therapies, highlighting the need for novel targeted low-toxicity strategies. Nutrient restriction interventions, such as fasting and fasting-mimicking diets (FMD), modulate conserved growth pathways (IGF-1/AKT/mTOR, AMPK) and enhance cellular stress …
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The pharmaco-economics of combination therapies : a study of the effects of component and market factors on combined therapy price
For a growing number of indications, combination therapies are becoming increasingly common due in part to their superior efficacy, as compared to monotherapies. In fact, in the case of infectious diseases such as AIDS and tuberculosis, combination therapies are now the standard of care. With the …
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AI Assisted Cellular and 3D Spheroid Analyses for Combined Therapies Against Glioblastoma
… of only 15 months despite maximal therapy. While combination therapies involving radiation with immunotherapies, epigenetic therapies, molecularly targeted therapies, etc., show promise, current methods for evaluating whether combination therapies work are slow, need extensive manual analysis, and …
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An Innovative Phase I Trial Design Allowing For The Identification of Multiple Potential Maximum to lerated Doses With Combination Therapy of Targeted Agents
Treatment for cancer often involves combination therapies used both in medical practice and clinical trials. Korn and Simon listed three reasons for the utility of combinations: 1) biochemical synergism, 2) differential susceptibility of tumor cells to different agents, and 3) higher achievable …
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Predictive Computational Modelling of the c-myc Gene Regulatory Network for Combinatorial Treatments of Breast Cancer
… therapy. This can be avoided by combining therapies, but finding viable combinations experimentally is expensive and time-consuming. However, there is also cooperation between sub-clones, and being able to better model and predict these dynamics could allow this interdependence to be …
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Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity
… to the current front-line artemisinin-based combination therapies, there is an increased risk of malaria morbidity and mortality as limited replacement treatments are currently available. For that reason, it is essential to invest in the discovery of compounds with novel mechanisms of action …
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Combined Inhibition of Lysine-Specific Demethylase 1 and Kinase Signaling as a Preclinical Treatment Strategy in Glioblastoma
… could be exploited through rationally designed combination therapies. We hypothesized that LSD1 inhibitors would activate kinase signaling pathways, such as MAPK, and the addition of kinase inhibition would enhance their efficacy.</p> <p>Glioblastoma stem cell (GSC) lines and normal human …
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IDENTIFICATION OF AN EFFECTIVE RIBONUCLEOSIDE ANALOGUE AND IMMUNOMODULATORY IMIDE DRUG COMBINATION FOR MULTIPLE MYELOMA
… the current standard treatments mainly involve combination therapies targeting multiple pathways. Despite rapid advance in therapeutics, MM remains incurable and most patients eventually relapse. To identify effective novel drug combinations against MM, we applied our quadratic phenotypic …
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Investigating pathogen 4Fe-4S protein targets and cancer chemotherapies with bisphosphonate/diphosphate inhibitors
… of novel cancer drugs focuses on mono- and combination therapies targeting the farnesyl pyrophosphate synthase (FPPS) and GGPPS (geranyl geranyl pyrophosphate synthase) enzymes with drugs that interact with several pathways involved in autophagy and apoptosis.
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Evaluating the cost-effectiveness of artemisinin-based combination antimalarial drugs and malaria rapid diagnostic tests within the context of effective vector control : case study of Southern Africa
… vector control, the change to artemisinin-based combination therapies (ACTs) as first line malaria treatment and to evaluate the relevance of using definitive diagnosis (as opposed to clinical diagnosis) as the basis for initiating malaria treatment, especially when using ACTs for treatment. The …
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Assessment of the in vitro efficacy of aspirin and aspirin analogues in combination with standard chemotherapeutics in glioma cell lines
… often due to therapeutic resistance, however combination therapies have been proven to have a beneficial effect on the prognosis of patients. Aspirin, one of the most commonly used drugs reduces the viability and proliferation of glioblastoma both in vitro and in vivo. This study examined the …
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Essays in Industrial Organization
… Lensman, studies the innovation of cancer drug combination therapies. Innovations often combine several components to achieve outcomes greater than the “sum of the parts.” We argue that such combination innovations can introduce an understudied inefficiency—a positive market expansion …
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Quantitative analysis of non-viral gene therapy in primary liver culture systems
… caused by genetic abnormalities, provide novel combination therapies for cancers and viral infections, and offer a new and effective platform for next generation vaccines. However, after more than three decades of research and development efforts, clinical success has yet to be realized. …
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Mechanism-based rational design of cisplatin analogues
… the rational design of cisplatin analogues or combination therapies. Chapter I provides a survey of recent developments in the understanding of the mechanism of cisplatin action and summarizes relevant platinum-based anticancer compounds. Chapter 2 describes a series of estrogen-tethered …
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