Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Combination antiretroviral therapy"”.
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INFLAMMATORY AND T-CELL HOMEOSTASIS PARAMETERS IN DUAL AND TRIPLE COMBINATION ANTIRETROVIRAL THERAPY (CART) FOR HIV INFECTION
… immune activation and inflammation despite combination antiretroviral therapy (cART). While cART has transformed HIV into a manageable chronic condition, it remains unable to eradicate the virus or fully restore immune homeostasis. This study explores two critical aspects of HIV management: …
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Factors associated with different responses to combination antiretroviral therapy in an observational cohort study of HIV-1 infected patients
The introduction of combination antiretroviral therapy (cART) into clinical practice for the treatment of HIV in 1995-1996 has led to dramatic reductions in mortality and morbidity. Factors linked to a positive response to therapy include a potent and tolerable regimen, good adherence and low …
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The Plasma, Whole Blood and Intracellular Concentrations of Antiretroviral Agents in South African Children Receiving Combination Antiretroviral Therapy with and without Concomitant Antitubercular Treatment
… and lopinavir/ritonavir (ratio 1:1) as part of antiretroviral therapy are used in combination with rifampicin-based antitubercular treatment in South African TB/HIV co-infected children. Adult studies show that concomitant rifampicin significantly reduces efavirenz and lopinavir plasma …
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Evaluation of the Impact of the Provision of Triple Combination Antiretroviral Therapy to Employees Through the In-House Health Programme at a Large South African Mining Company
… as a result of HIV related illness through a combination of absenteeism and so called ‘presenteeism’1 as well as death due to AIDS and the resultant increase in employee turnover, has motivated companies to implement workplace HIV education, prevention and treatment programmes over and above …
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Survival, virological and immunological outcomes of HIV-infected children accessing ART at South African primary health care clinics
… the world’s largest pediatric HIV epidemic. Combination antiretroviral therapy (ART) is the only effective treatment for HIV virus suppression. Pediatric HIV care has traditionally been provided in academic research and tertiary care facilities, however efforts to improve ART availability for …
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Development of a Modular Anti-HIV Transducer Protein
The combination antiretroviral therapy (cART) suppresses Human Immunodeficiency Virus (HIV) infection and allows restored long-term health in people living with the HIV. Current treatment provided infection management but not a complete cure. In the absence of treatment, virus level rebound due to …
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DTI-based tractographic analysis of white matter alterations in HIV infected children
Despite early combination antiretroviral therapy (cART) administration, children born with human immunodeficiency virus (HIV) continue to demonstrate neurodevelopmental abnormalities. Often, there is a link between structural and functional abnormalities. Previously, we found HIV-associated changes …
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Evaluating individuals with extreme phenotypes of HIV-1 contributes towards better healthcare management of all HIV-1 positive individuals
… events or death for those immediately initiating combination antiretroviral therapy (cART) (vs not immediately initiating) among those with high CD4 cell counts (>500cells/mm3) and high HIV-RNA (>100,000 copies/ml). We contributed towards the ‘what cART to start’ question; among individuals …
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Development And Validation Of Novel Transmitted/founder Shivs For Hiv-1 Persistence And Cure Research
… kinetics and persistence during suppressive combination antiretroviral therapy (cART). These SHIVs demonstrated consistent early viral kinetics, rapid viremic suppression following cART initiation, and viral rebound following treatment interruption, mirroring HIV infection. Reservoir analyses …
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Virologic outcomes of HIV-infected children undergoing a single-class drug substitution from Lopinavir/Ritonavir- to Efavirenz-based antiretroviral treatment: A retrospective cohort study
… However, maintenance of excellent adherence to combination antiretroviral therapy (cART) lifelong is required to achieve optimal benefits. In addition, treatment options for children are limited by potential drug-resistance following PMTCT exposure, availability of appropriate and palatable …
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Investigation of protein biomarkers in HIV positive and HIV negative associated DLBCL
… lymphoma has decreased since the introduction of combination antiretroviral therapy (cART) in the mid-1990s. However, NHL, especially DLBCL remains the most common cause of morbidity and mortality among people living with HIV/AIDS, especially in sub-Saharan Africa where 70% of the global HIV/AIDS …
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Characteristics of decidual macrophages and Hofbauer cells in placentas of HIV positive women on antiretroviral therapy
… birth outcomes amongst HIV-1 infected women on combination antiretroviral therapy (ART) are not well characterized. In this Ph.D. dissertation, the impact of HIV-1 infection and the duration of ART exposure on the phenotype and function of decidual macrophages and HCs was studied. Birth outcomes …
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Assessment of a diabetes symptom screening checklist and associated factors of impaired fasting glucose among ART patients on Copperbelt province
… been some evidence that because of life saving combination Antiretroviral therapy (cART), people living with HIV are living longer and it is apparent that they are at an increased risk of developing non communicable diseases (NCD) including diabetes mellitus. Despite this recognition, not much …
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Assessment of a diabetes symptom screening checklist and associated factors of impaired fasting glucose among ART patients on Copperbelt province
… been some evidence that because of life saving combination Antiretroviral therapy (cART), people living with HIV are living longer and it is apparent that they are at an increased risk of developing non communicable diseases (NCD) including diabetes mellitus. Despite this recognition, not much …
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Multimodal neuroimaging signatures of early cART-treated paediatric HIV - Distinguishing perinatally HIV-infected 7-year-old children from uninfected controls
… children from the Children with HIV Early Antiretroviral Therapy (CHER) trial in Cape Town, who initiated combination antiretroviral therapy (cART) in infancy and had their viral loads suppressed from a young age, and 55 HIV- control children. Neuroimaging features were extracted to …
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Morbidity from antiretroviral metabolic effects in Africa: The Mama Study
Introduction: Combination antiretroviral therapy (ART) has considerably reduced both the morbidity and mortality of Human Immunodeficiency Virus (HIV) infection and its associated complications, thus effectively transforming a fatal disease into a manageable chronic condition. However, the chronic …
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Functional Expression of ABC Transporters at Blood-tissue Barriers: Relevance to Antiretroviral Drug Tissue Distribution
Although combination antiretroviral therapy is successful in reducing HIV-1 viral loads in plasma, several tissue compartments i.e., the brain and male genital tract have been identified as viral reservoirs which can harbor actively replicating HIV-1 virus (Chan, 2005;Dahl, et al., 2010;Smith, et …
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Dynamics of the HIV-1 Latent Reservoir
… replication and prevent HIV transmission is combination antiretroviral therapy (ART), which prevents HIV from infecting new cells. Despite the efficacy of ART, long lived latently infected cells persist, with an estimated half-life of 44 months, and circulate throughout the infected host …
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Classification of HIV virological failure using whole blood versus plasma viral load
… monitoring approach for HIV infected patients on combination antiretroviral therapy (cART) as it is more sensitive than CD4 count and clinical monitoring. In resource limited settings, timely plasma separation and transportation to testing laboratories is a major barrier to the access of HIV viral …
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