Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Combination Treatments"”.
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Novel Phase I/II Designs for Cytotoxic and Cytostatic Agents, and Combination Treatments
… the EWOUC-NETS framework to two-agent combination therapies, addressing the complexity of multidrug regimens. It enables estimation of OBD contours in a multidimensional dose space while maintaining overdose and underdose control. Extensive simulations across varying toxicity-efficacy …
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Comparing Healthcare Resource Utilization and Costs in HFPEF patients using SGLT2-inhibitor Combination Treatments: A Retrospective Claims Analysis
… utilization (HCRU) and costs between these combination therapies remains limited. Methods: We conducted a retrospective cohort study using the Merative™ MarketScan® commercial and Medicare databases from 2019 to 2023 to compare HCRU and costs in adult patients (≥18 years) with HFpEF …
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Elimination of Listeria monocytogenes in a Soft Cheese, Fromage Blanc, Using Processing Methods, Formulation Changes, and Additive Bacteriocin Nisin
… in artificially contaminated cheese. Treatments implemented included use of additional starter culture in formulation (25% more starter culture than original formulation), use of a higher temperature draining process (at 45oC instead of 22oC), addition of the anti-listerial bacteriocin …
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Investigating the metabolic impact of Metformin and Berberine in combination with Venetoclax for Acute Myeloid Leukaemia treatment
… on AML cell death and metabolic changes. The combination of Metformin and Venetoclax (Met+Ven) showed a synergistic cell death response in the HL60 cell line, unlike Berberine and Venetoclax (BBR+Ven). The combination treatments increased lactate production compared to their monotherapy, …
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Effects of prescribed burning, mechanical and chemical treatments to curtail rhododendron dominance and reduce wildfire fuel loads
… to determine the effects of seven silvicultural treatments on both the fuel loading within an R. maximum thicket and the control of R. maximum as a forest weed. The final objective of the project was to determine the cost effectiveness of each implemented treatment. Due primarily to moisture …
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Structure-activity and structure-property relationships of antimalarial pyrimido[1,2-a]benzimidazoles, imidazo[1,2-a]pyridines, and imidazo[1,2-a]pyrimidines
… widespread rise of parasite resistance, current treatments may no longer be effective. Furthermore, artemisinin-based combination treatments (ACTs), which are the first-line antimalarial medications currently recommended by the World Health Organization (WHO), are restricted in availability, …
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Induction of death in myeloid leukaemia cells by doxorubicin and betulinic acid, singly and in combination was associated with the regulation of apoptosis, autophagy and the PI3K/Akt pathways
… Dox and a bioactive compound BetA, singly and in combination. The cytotoxic effect of the compounds was measured by CyQUANT Direct® (which estimates cell numbers by nuclear content of viable cells). Proliferation rate (using 5(6)- carboxyfluorescein diacetate succinimidyl ester) and cell death …
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Cip4 and Src In Promoting The Migration and Invasion of Breast Cancers
… synergistic inhibition of proliferation with combination treatments. The Src-targeted protein CIP4 (Cdc42-interacting protein 4) associates with curved plasma membranes to scaffold complexes of Cdc42 and N-WASp. In these experiments, I show that CIP4 overexpression correlates with …
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Developing a co-culture model of ovarian cancer to identify immunotherapies that can overcome TGF-β-induced immunosuppression
… of the HGSC TME to test immunotherapies and combination strategies capable of overcoming a high-TGF-β environment. ID8 p53-/- Nf1-/- cells were transduced with a GzmB-cleavable Förster resonance energy transfer (FRET) reporter and either the chicken ovalbumin (OVA) epitope or scrambled (SCR) …
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Targeting the actin cytoskeleton in HER2+ metastatic cancer cells using a macrolide toxin
… ADCs, we tested the effects of a combination of Trastuzumab and MycB on cell migration and invasion. We found that MycB/ Trastuzumab combination treatments inhibited motility of SKOV3 cells to a greater degree than either treatment alone. Altogether, our results provide …
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Development of nanocrystalline Fe80Cr20 alloy using combination technique of ball milling and ultrasonic treatment for fuel cell interconnector
… it was found that there are no works on these combination treatments (milled and UT). Characterization and analysis were carried out to all samples by using X-Ray Diffraction (XRD), Scanning Electron Microscope (SEM) and Energy dispersive X-ray Diffraction (EDS), Thermo Gravimetric Analysis …
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Investigating the role of the Renin Angiotensin System in cancer
… as anticancer therapies as single agents or in combination treatments with current chemotherapeutics.
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Incorporating the Experimental Herbicide CGA 362622 into Cotton Weed Management Programs in Virginia
… yield. Broadleaf weed control from herbicide combinations with CGA 362622 generally controlled weeds more consistently than individual herbicide applications. Timely applications of CGA 362622 controlled common ragweed (Ambrosia artemisiifolia L.), common lambsquarters (Chenopodium album L.), …
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Targeting Akt/Mtor Signaling Pathways During Murine Skin Tumor Promotion and The Impact of Dietary Energy Balance Manipulation
… mTORC1 inhibition via rapamycin, metformin or combination treatments greatly inhibited skin tumor development in normal, overweight and obese mice. Furthermore, mechanisms by which these chemopreventive agents may be exerting their anti-tumor effects were explored. In addition, the effect of …
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Reclamation of fine-textured sodic soil using gypsum, langbeinite, and calcium chloride
… batch studies showed that CaCl₂ and langbeinite treatments were more efficient in the displacement of Na than gypsum which increased with increasing application rate. In contrast, with gypsum, Na displacement increased to a maximum at an application rate of 7 tons/ha; then, no further increase in …
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GSK-3 Inhibition: A Novel Approach to Sensitization of Chemo-resistant Pancreatic Cancer Cells
… urges the need for developing more effective treatments. Many studies have attributed resistance to therapeutics of pancreatic cancer to activity of the transcription factor nuclear factor kappa B (NF-kB). NF-kB is regulated by the serine/threonine kinase glycogen synthase kinase-3 (GSK-3). …
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Proteasome Inhibition As A Potential Anti-Breast Cancer Therapy: Mechanisms Of Action And Resistance-Reversing Strategies
… their crosstalk and might help in designing new combination treatments for difficult to treat solid tumors like TNBC.</p>
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Exploring the effect of alpha2 receptor on brain 5-HT via a mechanism-based pharmacodynamic model
… and not well explored. Especially in different combination treatments, the receptor systems may show varied modulation capability. Additionally, some research has suggested that α 2 heteroceptors may contribute to the time delay problem in dual depression treatment which is thought as the time …
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Deciphering The Role of miR-506 in Ovarian Cancer Drug Sensitivity
… in chemosensitising EOC cells to different treatments. I demonstrated that miR-506 expression, by targeting RAD17, was able to mediate sensitisation to platinum treatment and accordingly RAD17 silencing exerted the same effect. MiR-506 expression in EOC cells led to a reduced ability to …
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Exploring the in vitro effects of Helichrysum petiolares for its potential to provide cardioprotective benefits against Doxorubicin toxicity
… or Dox for three hours, followed by inverse or combination treatments for 24 hours under standard cell culture conditions. Antioxidant capacity was evaluated using the 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) assay, while metabolic activity was assessed via the Water-Soluble Tetrazolium-1 (WST-1) …
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