Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 84 for “"Combination Treatment"”.
-
Combination Treatment of Angiotensin-II Receptor Blocker and Angiotensin-Converting-Enzyme Inhibitor in Non-Diabetic Renal Disease on Effect of Reducing Proteinuria
… in even greater renoprotection when used in combination. But many studies have failed to distinguish clearly between the additive intrinsic renoprotective effect. So we aimed to assess the efficacy and safety of combined treatment of ACEI and ARB, and monotherapy of each drug in patients with …
-
Investigating a novel combination treatment of androgen deprivation therapy, pelvic external beam radiotherapy and radium-223 dichloride in the management of hormone sensitive prostate cancer metastatic to bone
… an incurable condition, for whichthe mainstay of treatment consists of androgen deprivation therapy (ADT).Recently a number of treatments added to ADT have been shown to extend survivalin these patients including docetaxel and abiraterone as well as external beamradiotherapy (EBRT) to prostate (in …
-
Development of nanocrystalline Fe80Cr20 alloy using combination technique of ball milling and ultrasonic treatment for fuel cell interconnector
… ball milling (milled) combined with ultrasonic treatment (UT) in obtaining smaller crystallite size, finer surface morphology, higher thermal stability and more homogenous nanocrystalline Fe80Cr20 alloys. This condition was motivated by the previous research that some of the grain growth was …
-
Targeting DNA Repair in Prostate Cancer: Therapeutic Combinations & Disease Models
… patients with and without defective homologous recombination repair defects, when combined with standard-of-care antiandrogen therapies. However, the dominant molecular mechanisms underlying tumour cell responses to DNA repair and antiandrogen combination treatment remain unascertained. Within …
-
A COMBINATION THERAPY OF NICOTINAMIDE AND PROGESTERONE FOR FUNCTIONAL RECOVERY FOLLOWING TRAUMATIC BRAIN INJURY
… there are no federally approved pharmacological treatments. Preclinical trials with nicotinamide (NAM) and progesterone (Prog) treatment demonstrate beneficial neuroprotection and recovery of function following TBI. The primary goal of this study was to assess both neuroprotection and recovery of …
-
Effects of Penfluridol On Integrin-Fak Signaling and Tumor Cell Killing In Combination With Oncolytic Hsv In Glioblastoma
… expression at a transcriptional level, in combination with oncolytic herpes simplex I virus (oHSV) in a glioblastoma model. We examined the effects of oHSV on FAK signaling by looking at FAK phosphorylation at different time points post-infection and saw that FAK was activated by viral …
-
Regulation of autophagy, endoplasmic reticulum and unfolded protein response by glucocorticoids in physiology and disease
… how GC-resistant leukemic cells respond to Dex treatment, combination treatment of Dexamethasone with Chloroquine (CLQ), Thapsigargin (TG), Rotenone (ROT) and Bortezomib (BTZ) were used to investigate the role of autophagy, endoplasmic reticulum stress (ER stress) and unfolded protein response …
-
Interaction of exercise and simvastatin on myocardial ischemia-reperfusion (I/R) injury and post-ischemic cardiac function
… Patients are frequently advised to undergo a combination treatment of statins and chronic exercise, although little is known about how this combination treatment affects cardioprotective adaptations. Both treatments appear to exert their cardioprotective effects through different mechanisms, …
-
Targeted Inhibition of Sp1 Transcription Factor and Anti-Angiogenesis of Human Pancreatic Cancer
… genes expression were suppressed by mithramycin treatment both in vitro and in vivo. Moreover, mithramycin treatment reduced MVD in vivo. This was consistent with the down-regulation of VEGF, PDGF, and EGFR. Human xenograft pancreatic tumor growth was suppressed by Bevacizumab treatment. Both …
-
Synthetic Lethality of Cdk Inhibition and Doxorubicin In Triple-Negative Breast Cancer Requires P53 Inactivation
… and must rely on chemotherapy and surgery for treatment. While initially responding well to chemotherapy, TNBC patients are at increased risk of developing distant metastasis and have decreased overall survival compared to non-TNBC patients. A majority of TNBC tumors carry p53 mutations, …
-
Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
… form of cancer, notorious for its limited treatment options, resistance to chemotherapy, and consequent poor prognosis. This dissertation comprehensively explores the potential of targeting the urokinase plasminogen activator (uPA) system, a well-documented factor in cancer progression as a …
-
Immunotherapy for murine glioma
… immunotherapy is a novel approach to cancer treatment. Viruses can directly kill cancer cells, provide antigens to dendritic cells to stimulate a T cell response, and make cancer cells express genes of immune-enhancing cytokines locally within the tumor microenvironment. We hypothesized that …
-
BAD and Mcl-1 Regulation in Prostate Cancer
… to carry out their pro-survival function. Treatment of C42 cells with a PI3K inhibitor in the absence of survival factors results in BAD dephosphorylation within 3 hrs, however despite that fact, apoptosis becomes evident only after 12 hrs. In an attempt to decrease the amount of time it …
-
Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy
… with SMCs to kill cancer cells. The combined treatment of SMC and IFNα induces tumour regression in mice, and this effect is completely abrogated upon treatment with TNFα-neutralizing antibody. The synergistic effects are mediated by tumour cells and by contribution of immune cells, …
-
Mechanism-Based Strategies to Enhance The Actions of A
… to the degradation of client proteins. However, treatment with 17-AAG results in the elevation of the levels of antiapoptotic proteins HSP70 and HSP27, which may lead to cell death resistance. The increase in HSP70 and HSP27 protein levels is due to the activation of the transcription factor …
-
Lmw-E Mediates Mammary Tumorigenesis By Deregulating Acinar Morphogenesis & Generating Cancer Stem Cells
… <p>expression predicts poor patient survival. Combination treatment using roscovitine</p> <p>(CDK inhibitor) plus either rapamycin (mTOR inhibitor) or sorafenib (b-raf inhibitor)</p> <p>effectively prevented aberrant acinar formation in LMW-E-expressing cells by</p> <p>inducing the G1/S cell …
-
CHARACTERISATION OF A NOVEL SMALL MOLECULE INHIBITOR FOR IMMUNE ACTIVATION IN TRIPLE NEGATIVE BREAST CANCER
… of breast cancer with poor prognosis and limited treatment options. Our group has previously identified a novel small molecule inhibitor, CHL-4, whose anti-tumour effects function through Lyn kinase, a member of the Src family kinases. This current study characterised a novel immunomodulatory role …
-
SMAC Mimetics Sensitize HIV-Infected Cells to MG1-Mediated Death
… inhibitor necrostatin1-s, alone or in combination, indicating that cell death does not occur via a single pathway. SMAC mimetics have shown to activate the non-canonical NFκB pathway and cause TNFα-dependent or independent death in different models of HIV-infected cells. Here, it was …
-
Mathematical Modeling of Therapies for MCF7 Breast Cancer Cells
… course in ER-positive MCF7 breast cancer cells. Treatments included endocrine therapy, either estrogen deprivation, which mimics the effects of an aromatase inhibitor, or fulvestrant, an ER degrader. These data were used to calibrate a mathematical model based on key interactions between ER …
-
Intervention of non-small cell line cancer oncogenic pathways with delta-tocotrienol
… that delta-tocotrienol individually or in combination with cisplatin exhibited potent anticancer abilities in NSCLC cells by down-regulating oncogenic pathways such as Notch-1 and NF-ĸB pathways and up-regulating the tumor suppressor pathways such as Bcl-2, caspase-3. Decreased NF- κB …
Page 1 of 5