Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Colorectal cancer cell lines"”.
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Characterisation of the Helix pomatia agglutinin binding glycoproteins of colorectal cancer cell lines and tissue samples
Colorectal cancer (CRC) is one of the most common malignancies in the US and Western Europe and metastatic dissemination after CRC is a leading cause of mortality. New markers predictive of cancer cell behaviour are actively sought both as targets and as a means of predicting patient prognosis. The …
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Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines.
Colorectal cancer is one of the most severe causes of mortality worldwide accounting for 10% of total cancer cases. Although recent advances in early diagnosis have reduced the mortality rate associated with CRC, patients suffering from the later metastatic stage of the disease have a 5-year …
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Investigating the role of ALDH3B2 and FUT2 as potential risk genes to colorectal cancer through computational analysis and gene expression study of colonic cells, and utilizing colorectal cancer cell lines to explore gene-environment interactions
… to be involved in conferring risk to various cancers. Using a systems genetics approach of GWAS and TWAS, this study sought to investigate two identified genes, ALDH3B2 and FUT2, in order to better understand their potential contributions to colorectal cancer (CRC) risk. ALDH3B2, of the …
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Mechanisms and Consequences of Chromosomal Instability in Malignant tumours
… with chromosomal instability in established colorectal cancer cell lines and in Wilms tumour. In colorectal cancer cell lines, anaphase bridging was observed to generate both numerical and structural chromosomal aberrations and was also associated with the presence of multipolar mitoses. In …
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Functional Characterization of Protein Tyrosine Phosphatases in Tumorigenesis through Substrate Identification
… plays critical roles in literally every cellular process. Highlighting its importance, the dysregulation of tyrosine phospho-rylation leads to the pathogenesis of many human diseases including cancers. Tyrosine phosphorylation is regulated by two families of enzymes PTKs and PTPs. Despite …
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Design, Construction, and Screening of an shRNA Library Targeting Human Circular RNAs
… stability has prompted the study of circRNAs as cancer biomarkers. While expression studies are becoming widely used to profile circRNAs in multiple cancers, there are no genome-wide tools available to decrease their levels in cells. Methods that investigate the role of circRNAs through measuring …
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Development of in vivo tumour models for non-invasive proof-of-principle investigation of novel therapeutic agents. Engineering and characterisation of bioluminescent cell reporter systems for in vivo analysis of anti-cancer therapy pharmacodynamics.
Despite significant advances in cancer treatment, clinical response remains suboptimal and there is a continued requirement for improved chemotherapeutics. The attrition rate for new therapies is high, due principally to lack of in vivo efficacy and poor pharmacodynamics. Consequently better …
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Proteogenomics for Personalised Molecular Profiling
… insights into gene expression regulation, cell signalling, and disease processes. However, the lack of software tools for high-throughput integration and unbiased modification and variant detection hinder efforts for large-scale proteogenomics studies. The main objectives of this work are …
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Detection of Aneuploidy for Chromosomes 7 and 8 Using Fluorescence <i>In Situ</i> Hybridization in Patients with Aplastic Anemia and Sequencing of the Mitotic Checkpoint Gene hBUB1
… checkpoint gene, was shown to be mutated in two colorectal cancer cell lines with high levels of aneuploidy (Cahill, et al., 1998). Although theoretically possible, conclusive evidence does not currently exist establishing a link between aneuploidy levels and mutations within a mitotic spindle …
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THE AUTOPHAGIC RECEPTOR P62 MODULATES MICRONUCLEUS STABILITY
… and the catastrophic consequences for the cells harboring them, I investigated the cellular mechanisms that may be responsible for sensing and recognizing these extranuclear bodies. Notably, I found that the autophagic receptor p62 recognizes micronuclei. p62 localizes to micronuclei …
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Genomic analysis in human solid tumours:Copper Homeostasis Genes in Colorectal cancer
… have been discussed: 1. The public database: Cancer Genome Atlas Network has been consulted in order to reveal the presence of somatic mutations in copper homeostasis genes (CHGs) in colorectal cancer, and such analysis, performed on 228 colorectal tumor samples, has revealed that inactivating …
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Estudio de los lncRNAs MDL1 y MDL1AS en diferentes tipos de tumores y su relevancia clínica en adenocarcinoma rectal
Cancer is the leading cause of death in the world, and it is estimated that the incidence of this disease will increase in the coming years. Among the most common types of cancer are breast, lung and colorectal cancer, while those with the highest mortality rates are lung, colorectal and liver …
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Biomedical applications for bacteriocins in infection and oncology
… aid of new antimicrobials. Given that the anti-cancer effects of bacteriocins have been largely unexplored, in Chapter 4 we investigate the potential use of nisn Z as an alternative treatment for colorectal and oesophageal cancers, which have with high incidence and poor prognosis. It was …
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Prognostic role of tumour associated trypsin inhibitor in colorectal cancer patients
Colorectal cancer (CRC) is one of the most common forms of human cancer worldwide with approximately 1 million new cases detected every year. CEA is currently the only accepted CRC marker incorporated into clinical practice, where it is used for early detection of metastasis in follow-up of …
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Interrogating novel functions of the I kappa B kinases via CRISPR-Cas9 gene editing and small molecule inhibition
… signalling pathway is a critical mediator of the cellular responses to inflammatory cytokines. The IκB kinase (IKK) complex, which is composed of two catalytic subunits (IKKα and IKKβ) and one regulatory subunit (IKKγ/NEMO) acts as the master regulator of NF-κB transcription factor activity. …
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RNA Interference and cyclooxygenase-2 (COX-2) regulation in colon cancer cells
… methods and combined strategies, conventional cancer chemotherapy still lacks specificity and induces drug resistance. Gene therapy can offer the potential to obtain the success in the clinical treatment of cancer and this can be achieved by replacing mutated tumour suppressor genes, inhibiting …