Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 173 for “"Colorectal cancer (CRC)"”.
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Colorectal cancer : a neuropsychological approach to non-adherence to screening guidelines of individuals with Lynch syndrome in the Western Cape
… syndrome (LS), the most common form of inherited colorectal cancer (CRC), carries with it a lifetime risk of approximately 80% of developing CRC. This study identified unexpected findings with regard to the relationships between neuropsychological functioning, knowledge and non-adherence within …
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Cancer free survival in mutation positive HNPCC individuals with colorectal adenomatous polyps identified on surveillance colonoscopy
The prevalence of colorectal cancer (CRC) places it in the top five cancers worldwide and is the second most common cause of cancer related death. Developed populations have a 5-6% lifetime risk of CRC(l). The South African Cancer Registry (last updated 2004) shows a 1/98 and 1/150 life time risk …
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The molecular genetic and epidemiological investigation of colorectal cancer in South Africa
Cancer of the colon and rectum is the third-most common cause of death due to neoplasia in Western countries. Colorectal cancer (CRC) can broadly be divided into the hereditary, non-hereditary and sporadic forms. Hereditary cancers account for approximately 10% of the CRCs. Familial cancers can be …
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Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort
… to elucidate whether the MMR status of a colorectal cancer (CRC) cohort will define a response to 5-FU therapy. However, no difference in long term response or survival after 5-FU treatment between patients with MMR-proficient and MMR-deficient tomours were detected.
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Signatures of gut microbes in human diseases
… (PD), inflammatory bowel diseases (IBD), and colorectal cancer (CRC).
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TARGETED POLYMER NANOPARTICLES FOR THE DETECTION AND TREATMENT OF DISSEMINATED COLORECTAL CANCER IN VIVO
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths and the fourth most common cancer in the United States. When CRC disseminates into the abdominal cavity, there can be hundreds, if not thousands, of small tumors infiltrating the surfaces of organs, making it extremely …
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Novel genomic technologies and molecular diagnostics in Colorectal Cancer
Cancer is a disease of the genome that is characterized by substantial variability in the clinical course and response to therapies. Colorectal cancer (CRC) is a heterogeneous cancer and represents an ideal model to investigate and elucidate the genetic alterations involved in tumor onset and …
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SHAPE INFLUENCE IN MEDICAL IMAGE SEGMENTATION WITH APPLICATION IN COMPUTER AIDED DIAGNOSIS IN CT COLONOGRAPHY
… images. The application of CAD in screening colorectal cancer (CRC) has been studied for more than two decades. CRC is the second most deadly form of cancer in men and women in the United States. Nearly all CRC arises from polyps and is preventable if polyps are removed in their early stage. …
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Social Determinants of Health and Uptake of Colorectal Cancer Screening in Canada
Colorectal cancer (CRC) screening uptake may be associated with social determinants of health and could indicate potential barriers to health service access. The goal of this thesis was to evaluate the association of social determinants with CRC screening in screen-eligible adults. We used …
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Cognitive and emotional barriers to colorectal cancer surveillance: Increasing screening rates within the community
<p>Background: The rate of colorectal cancer (CRC) screening in the United States continues to be low, allowing colorectal cancers to remain undiagnosed and mortality rates to remain high. Current literature points to lack of education, healthcare access, and physician counseling as key barriers to …
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Inherited risk for common disease
… complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular diseases, and diabetes. Such studies, however, depended on the untested assumption of monoallelic risk. My research advisor and I set out to investigate whether simple forms of inherited risk, monoallelic …
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Delineating metastasis in MSS colorectal cancer by single - cell RNA sequencing
<p>Colorectal cancer Colorectal Cancer (CRC) is the leading cause of cancer-related deaths, with the majority of these deaths occurring after metastases. In this study, we used single-cell RNA transcriptome sequencing to characterize the cellular and molecular features of primary CRC and colorectal …
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Overcoming Literacy Barriers in Colorectal Cancer Screening: a Randomized Trial of a Web-based Decision Aid
… web-based decision aid (DA) could increase colorectal cancer (CRC) screening rates in both low and high literacy patients. Methods: Patients at a community-based health center who were overdue for CRC screening were randomized to view either the web-based CRC screening DA or a control …
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Proline-rich acidic protein 1 in Life and Death
… activity and may aid bacterial phagocytosis. In colorectal cancer (CRC), PRAP1 is a downstream target of p53 and plays a protective role against genotoxic stressors. Repression of PRAP1 significantly enhances the anti-tumor effect of chemotherapeutic drugs used in the treatment of CRC. This is …
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Lessons from a pilot study of screening for upper tract urothelial cell carcinoma in Lynch Syndrome
… with a very high risk of the developing colorectal cancer (CRC) and a predilection to develop other cancers, including upper tract urothelial carcinoma (UTUC) that has an estimated lifetime risk of 0.2-25%, above that of the general population. Our aim was to assess the prevalence of UTUC …
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Effects of m6A DNA methylation by bacterial methyltransferase in colorectal cancer
… methylation by bacterial methyltransferase in colorectal cancer Fabian Alejandro Mendoza Galvan Advisory Professor: Angela H. Ting, Ph.D. Fusobacterium nucleatum animalis (Fna) is found in the human oral cavity and gut. A distinct clade of Fna is primarily enriched in the tumor microenvironment …
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Design, Synthesis and Biological Evaluation of Novel Estradiol-Triazole Analogs Targeting Epidermal Growth Factor Receptors in Colorectal Cancer
<p>Colorectal cancer is a life threatening and second cause of death from cancer in the United States. Several proteins (molecular targets) are highly expressed in Colorectal cancer (CRC). Among these molecular targets is Epidermal Growth Factor Receptors (EGFRs) which are overexpressed in cancer …
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DISSECTING RESISTANCE TO IMMUNOTHERAPY IN MSS COLORECTAL CANCER
Patients with colorectal cancer (CRC) exhibiting DNA mismatch repair deficiency and microsatellite instability (MSI) often display favorable responses to immune checkpoint inhibitor (ICI) therapies, in contrast to mismatch repair proficient and microsatellite stable (MSS) tumors. While the high …
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Protein L Functionalized Microparticles For Early Detection of Surface Markers In Heterogeneous Colorectal Lesions
<p>Colorectal cancer (CRC) is the third leading cause of cancer-related deaths among both men and women worldwide, a statistic that can be improved with early detection. Increased understanding of the tumor landscape has identified surface antigens that can be utilized to distinguish normal and …
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Nherf1 – New Modifier of Colorectal Cancer Progression
Colorectal cancer (CRC) develops from multiple progressive modifications of normal intestinal epithelium into adenocarcinoma. Loss of cell polarity has been implicated as an early event in this process, but the molecular players involved are not well known. NHERF1 (Na+/H+ Exchanger Regulatory …
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