Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Colorectal Neoplasms"”.
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A possible mechanistic role for microorganisms in the genesis of colorectal cancer.
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States. An estimated over 140,000 people will be diagnosed with CRC and over 50,000 people will die in 2013. CRC tumors develop from a polyp but the initial cause of the chromosomal instability and mutations …
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Colon Cancer Initiation and Progression
… we sought to functionally interrogate candidate colorectal cancer genes (CAN-genes) to identify driver tumor-suppressors. We have developed an isogenic human colonic epithelial cell (HCEC) model to identify suppressors of anchorage-independent growth by conducting a soft agar based shRNA screen …
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Safety and Effectiveness of Cecal Retroflexion in Evaluating Proximal Colon: A Case Series
BACKGROUND: Cecal retroflexion is a maneuver used by colonoscopists to evaluate the proximal sides of the colonic folds in the right-sided colon. Knowledge is limited regarding cecal retroflexion-associated risk and its effectiveness for increasing neoplasia detection rates in proximal colon. …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
… gene that is mutated in the vast majority of colorectal tumors. Inactivation of this gene is a key and early event in colorectal tumorigenesis. APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. Further studies have suggested that APC plays …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
… gene that is mutated in the vast majority of colorectal tumors. Inactivation of this gene is a key and early event in colorectal tumorigenesis. APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. Further studies have suggested that APC plays …
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Using Tissue Morphology to Infer Intra-Tumor Variation in Molecular State and Response
… clear-cell renal cell carcinoma (ccRCC) and colorectal cancer (CRC). In ccRCC, we aim to understand the extent to which intra-tumor variation in key driver genes, BAP1, PBRM1, and SETD2, can be inferred purely from the analysis of histopathology slides. Our work demonstrated for the first …
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Vegetarian Dietary Patterns: Mortality, Colorectal Cancer, and Food Consumption
… diets, particularly for all-cause mortality and colorectal cancer risk, have yielded inconsistent results. We sought to examine these outcomes (mortality and colorectal cancer incidence) in a large North-American cohort. We also sought to further characterize potentially important differences in …
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The dynamics of the serum concentration of CEA, CA15-3 and CA19-9 and survival in patients treated for advanced breast and colorectal cancer. The determination of the prognostic correlates of changes in tumour markers CEA, CA15-3 and CA19-9 during chemotherapy treatment for advanced breast and colorectal cancer.
… over time in patients with advanced breast and colorectal cancer but the literature contains differences in methodology so comparing findings is difficult. By modifying criteria developed by Rustin and colleagues [1-5] in ovarian carcinoma we have retrospectively identified a subset of patients …
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Let me be part of the plan - Experiences of information and information needs after colorectal cancer surgery
… information needs after being discharged after colorectal cancer surgery. The aim was also to study factors related to this. Different methods were combined in this explorative study in order to obtain diverse types of data. Patients who had undergone surgery for colorectal cancer at three …