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Showing 1 to 20 of 76 for “"Colony stimulating factor"”.
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Controlling Pseudomonas aeruginosa Persister Cells by Human Granulocyte Macrophage Colony-Stimulating Factor
… this study, we focused on granulocyte macrophage colony-stimulating factor (GM-CSF), a cytokine produced by macrophages, T-cells, endothelial cells, and fibroblasts. We chose Pseudomonas aeruginosa as a model bacterium. It is an opportunistic pathogenic bacterium and a major cause of nosocomial …
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The role of complement and granulocyte colony stimulating factor in ANCA associated vasculitis
… thesis, the role of another cytokine, Milocyte-colony stimulation factor (GCSF) is examined both in vitro and in vivo. Previous i have implicated the complement system in ANCA vasculitis. Furthermore, TNFot •d neutrophils which have been activated with ANCA in vitro are known to release a >r …
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A new insight on direct actions of Granulocyte-Colony Stimulating Factor in the myocardium
… Faktor (engl. granulocyte colony- stimulating factor, G-CSF) ist ein bekanntes hämatopoetisches Zytokin, das die Proliferation und Differenzierung neutrophiler Voläuferzellen fördert. Da G-CSF den Verlauf ischämischer Myokardläsionen positiv beeinflussen kann, wurde …
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Monocytic Cells Mediate Granulocyte-Colony Stimulating Factor-Induced Mobilization of Hematopoietic Stem and Progenitor Cells
… a process known as mobilization. Granulocyte-colony stimulating factor: G-CSF), a hematopoietic growth factor, is the most widely-used mobilizing agent clinically. However, the mechanisms by which G-CSF elicits HSPC mobilization are not well-understood. The experiments described herein are …
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Colony Stimulating Factor-1 Receptor (CSF-1R) Expression, Degradation, and Signaling in Lipid-Laden Macrophages
… plaques is dependent on the macrophage growth factor colony stimulating factor-1 (CSF-1); however, understanding the changes in CSF-1 signaling and related pathways in foam cells remain poorly investigated. Lipid-laden macrophages were formed through exposure of murine bone marrow derived …
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Progesterone Enhances Macrophage Colony-Stimulating Factor(M-CSF) Production in Human Endometrial Stromal Cells in vitro
本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである
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Granulocyte Colony-Stimulating Factor Minimizes Negative Remodeling of Decellularized Small Diameter Vascular Graft Conduits but Not Medial Degeneration
… to investigate the influence of granulocyte colony-stimulating factor (G-CSF) on inhibiting adverse remodeling of decellularized SDVCs. METHODS: Sprague-Dawley rats implanted with allograft infra renal abdominal aortic conduits were divided into 2 groups according to whether they were treated …
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The Interplay of Signal Transduction and Membrane Traffic of the Macrophage Colony Stimulating Factor Receptor (MCSFR) Controls Macrophage Growth
<p>Macrophage colony stimulating factor receptor (MCSFR a.k.a CSF-1R), is a receptor tyrosine kinase (RTK) that is essential for the growth of myeloid stem cells, monocytes and macrophages. Proper control of signaling through the MCSFR is critical for proper macrophage development and function. …
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Transcriptional regulation of the GM-CSF gene in T lymphocytes / Cameron Stuart Osborne.
… as to whether the mouse granulocyte-macrophage colony-stimulating factor and interleukin-3 genes are regulated in a similar manner as those of the human, focussing on regulation through an enhancer.
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Sialylation as a mechanism for preferential Ligand binding in CFS1R
… is largely controlled by signaling through colony stimulating factor 1 receptor (CSF1R). Notably, this receptor can be activated by two non-homologous ligands, colony stimulating factor 1 (CSF1) and interleukin- 34 (IL-34). These two ligands are differentially required for macrophage …
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Vaccinia Virus Binding and Infection of Primary Human Leukocytes
… (MDMs), including granulocyte macrophage colony-stimulating factor (GM-CSF)-polarized M1 and macrophage colony-stimulating factor (M-CSF)-polarized M2, were permissive to VV replication. The majority of virions produced in MDMs were extracellular enveloped virions (EEV). Visualization of …
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Engineering scaffold and soluble cues for cell-instruction
… microenvironmental scaffold cues with soluble factor cues so as to enhance cell-instruction and tissue regeneration. In order for this aim to be accomplished, we started off by separately examining the control of microenvironmental cues and the regulation of soluble factor cues both in vitro …
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Tumor-induced macrophage and T cell dysfunction
… Tumor growth changed MΦ responsiveness to MΦ colony-stimulating factor (M-CSF). M-CSF did not reverse decreases in autorecognition caused by TBH MΦ, and increased TBH MΦ suppression during T-cell alloreactivity. TBH suppressor activities were associated predominantly with MHC class II MΦ. TBH …
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Immunomodulatory effects of lactic acid bacteria on human intestinal epithelial cells and macrophages in the context of a pro-inflammatory challenge
… cells (HT-29) induced by Tumor Necrosis Factor α was assayed by ELISA for interleukin-8 (IL-8). Granulocyte-macrophage colony stimulating factor (GM-CSF) production was assayed by ELISA in the HT-29 cell line. Strain-dependent differences were observed in the ability of viable bacteria …
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Regulation of Breast Cancer Cell Proliferation by APRIL
… cancer patients. APRIL is a tumor necrosis factor superfamily member that is implicated in lymphoid cell survival, proliferation and apoptosis. APRIL studies initially focused on lymphoid cells as known APRIL receptors are exclusive to these cells. However, I found that APRIL promotes breast …
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Manipulating macrophages to enhance liver regeneration
… I then tested the administration of macrophage colony stimulating factor in mouse models of partial hepatectomy, partial hepatectomy plus chronic liver injury and paracetamol intoxication, describing the phenotype and exploring mechanisms of action. Collaborating with others I assessed serum …
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Cytokine engineering through ligand/receptor dynamics : a study on granulocyte colony-simulating factor
Granulocyte colony-stimulating factor (GCSF) is a cytokine of great clinical importance, with application to elevate neutrophil counts in cancer patients undergoing chemotherapy. GCSF binds to its specific receptor (GCSFR) on bone marrow precursor cells and generates intracellular signals that …
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Relationship of General and Health-related Anxiety and Worry to Markers of Inflammation in Women with Advanced Cancer
… (IL), interferons (IFN) and tumor necrosis factors (TNF; IL-2, IL-4, IL-6, IL-10, IL-12, IFN-¿¿, TNF-¿¿, Granulocyte Macrophage Colony Stimulating Factor, Vascular Endothelial Growth Factor). Results indicated anxiety was positively related to humoral inflammatory markers, IL-4, while worry …
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Mechanistic studies on chemical instabilities of recombinant proteins
… residues in a model protein G-CSF (Granulocyte-Colony Stimulating Factor) was studied to address the issue of how protein structure affects its reactivity. Comparative oxidation studies were performed where the kinetics of oxidation of methionine residues by hydrogen peroxide (H₂0₂) in G-CSF and …
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