Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 108 for “"Colony formation"”.
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Use of growth factors and adhesive ligands to promote connective tissue progenitor colony formation from fresh marrow
… support, possesses factors that promote bone formation, and contains connective tissue progenitors (CTPs), a heterogeneous population of connective tissue stem and progenitor cells that contribute to neotissue formation. A major limitation to autologous bone grafts is the risk of surgical …
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The Role of AF9 and AF9-Mediated Protein Interactions in Hematopoiesis and Leukemogenesis
… protein, and may be required for leukemic transformation.</p><p>Using bone marrow progenitor cells isolated from conditional Af9 knockout mice, we examined in vitro differentiation of hematopoietic progenitor cells to the erythroid, myeloid and megakaryocytic lineages in the presence or absence …
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The effect of RAN inhibition on human colorectal cancer cells (CRC)
… such as proliferation, migration, invasion, and colony formation. MBZ downregulated Ran and induced apoptosis through inhibition of Bcl-2 expression as well as inducing caspase -3, -7, -9 and PARP cleavage. Moreover, MBZ showed an effect on immune response by down regulating C5a, IL-1ß and IL-1α …
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Engineered [beta]TCP-binding HER-family protein fusions and their use for improving osteoprogenitor- mediated bone regeneration
… and other relevant upstream processes like colony formation and proliferation should advance bone healing. One such ligand is the Epidermal Growth Factor (EGF). EGF, when presented tethered (tEGF) on non-graftable synthetic polymer substrates, induced growth and colony formation of CTPs with …
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Identification of Neuropeptide FF receptor 2 (NPFFR2) and its ligand NPFF as a factor to affect cancer progression
… E. Invasion assay 7 F. Wound healing assay 7 G. Colony formation assay 8 Ⅲ. 결과 9 Ⅳ. 고찰 26 Ⅴ. 결론 30 참고문헌 31 ABSTRACT 38
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The Role of Hspa9 in Mouse Hematopoiesis and IL-7 Receptor Signaling
… mice have a significant reduction in CFU-PreB colony formation in vitro, indicating a B-cell progenitor defect. This reduction in colony formation is hematopoietic-cell intrinsic and likely due to a functional B-cell progenitor defect, since B-cell progenitor frequencies in Hspa9+/- mice are …
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Preclinical Studies of Telomerase Inhibitor Imetelstat in Non-small Cell Lung Cancer
… Imetelstat was tested in a short-term liquid colony formation assay, a 5-day drug response assay, and long-term continuous treatment in vitro and in vivo. The panel of over 70 NSCLC cell lines used for this study ranged from 1.5 kb to 20 kb in average telomere length as well as a wide range in …
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The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity
… WT1 but not mutant WT1 inhibited erythroid colony formation as well as erythroid differentiation in suspension cultures. Suprisingly, both WT1 and mutant WT1 were able to inhibit myeloid colony formation and stimulated myeloid differentiation of cells grown i suspension culture. These …
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Notch Signaling Is Important in the Survival, Proliferation, and Self-Renewal of the Putative Breast Cancer Stem Cell Population
… that CSCs are responsible for breast cancer formation, progression and recurrence; therefore, a deeper understanding of the signaling pathways regulating CSC survival will benefit development of novel therapeutic strategies. Notch signaling, which is dysregulated in breast cancer and has been …
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Regulation of Hgf Expression By Δegfr-Mediated C-Met Activation In Glioblastoma Cells
… c-Met knockdown decreased anchorage-independent colony formation and the tumorigenicity of intracranial xenografts. Building on prior findings that ∆EGFR enhanced c-Met activation, we found that ∆EGFR also led to increased HGF expression, which was reversed upon ∆EGFR inhibition with AG1478. …
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Elucidating Cell Fate Regulation of the Bone Marrow Vascular Niche Through Development of Engineered Extracellular Matrices
… and functional tests revealed an improvement in colony formation potential. Continued development of the culture system and understanding of the molecular pathways at play can lead to improved patient outcomes after transplantation.
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Epigenetic silencing of gene expression in paediatric astrocytoma
… that re-expression of ii CXCL14 inhibited the colony formation and cell growth and reduces the migration rate significantly in IN699 short term culture and likely have functional significance in the development of paediatric HGA and an excellent candidate gene for further analysis. In parallel, …
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DEVELOPMENT AND CHARACTERIZATION OF POLYMER-OIL NANOSTRUCTURED CARRIER (PONC) FOR CONTROLLED DELIVERY OF ALL-TRANS RETINOIC ACID (ATRA)
… in the chemoresistant cells in both MTT and colony formation assays. Hence, this new ATRA-nanoformulation may offer promising means for the delivery of lipophilic compounds like all-trans retinoic acid to treat highly resistant ovarian cancer.
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Nprl2/Tusc4 Functions As A Tumor Suppressor By Regulating Brca1’S Stability Via The E3 Ubiquitination Pathway
… suppressed the proliferation, invasion, and colony formation of breast cancer cells <em>in vitro</em> and tumorigenesis <em>in vivo</em>. Furthermore, knockdown of NPRL2/TUSC4 expression transformed normal mammary epithelial cells and enhanced the sensitivity of U2OS cells to the treatment of …
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TUMOR-PROMOTING FUNCTION AND MOLECULAR REGULATION OF TSPAN8 IN LIVER CANCER
… TSPAN8 in the invasion and anchorage-independent colony formation of liver cancer cells. Moreover, orthotopic implantation of mouse liver cancer cells into synergetic recipient mice further unravelled that expression of TSPAN8 is required for their tumorigenesis. To discover the key regulators of …
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Evaluation of nanoscale delivery of miR 216 a/b, miR 217, and gemcitabine in pancreatic cancer cell lines
… apoptosis, and impaired cell migration and colony formation, compared to single-agent or polymer-alone treatments. To determine the underlying molecular mechanisms, Western blot analysis was conducted on lysates and supernatants from treated cells. Target proteins related to apoptosis, …
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Analysis of lipid metabolism regulators in breast cancer cells after induction of the Epithelial to Mesenchymal Transition
… in breast cancer cells enhances cell migration, colony formation, and chemotherapy resistance indicating PPAR-γ has critical role in breast cancer metastasis.
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Estradiol Regulation of Leucine-Rich Repeat Immunoglobulinlike Domains Protein 1 (Lrig 1) and Roles of Estrogen Receptor in Translational Regulation in Breast Cancer Cells
… for both the growth of cells as well as colony formation and invasiveness of ERalpha-positive and HER2-positive BT-474 and ERalpha-positive and HER2-negative MCF-7 breast cancer cell lines. LRIG1 regulation by estradiol may be important for breast cancer etiology and phenotypic properties …
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Define The Epigenetic Profiles and Subtype-Specific Genes of Breast Cancer
… overexpression decreases cell proliferation and colony formation specifically in claudin-low cells.</p> <p>The main deubiquitinase for H2Bub1 is USP22 in the DUB module of the SAGA complex. USP22 is the catalytic subunit of the DUB module. Two adaptor proteins, ATXN7L3 and ENY2, are necessary for …
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Wisp1 Is An Overexpressed Driver of Glioblastoma
… of WISP1 with shRNAs resulted in reduced colony formation <em>in vitro</em> and reduced tumor growth <em>in vivo</em>. Rescue experiments validated that the shRNAs were on target. Functional characterization of the protein revealed that the TSP module is necessary for the phenotype. …
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