Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Colonic crypt"”.
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Mechanism and role of calcium in excitation-mucus secretion coupling in human colonic epithelium
… (Ca2+) coupling mucus (MUC2) secretion in colonic goblet cells in situ, using an ex-vivo 3D model native human colonic crypt model system. Immunohistochemistry revealed the presence of cholinergic neurons in close proximity to the basal membrane of the crypts, where the muscarinic receptor …
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Wnt Signals and Imaging Tissue Renewal in the Human Colonic Epithelium
… of flask-like epithelial invaginations known as crypts. Within these crypts reside a stem cell population that continuously repopulates the epithelium with all of its specialised cell lineages. Many signalling pathways are involved in the regulation of these activities, the predominant one being …
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Prediction of nitric oxide concentrations during inflammation and carcinogenesis
… spatially varying NO concentrations within a colonic crypt under inflammatory conditions. A variety of scenarios were considered, including different spatial distributions of macrophages and a range of possible macrophage and epithelial synthesis rates for NO.
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Use of transgenic mice to study the role of autophagy protein ATG16L1 in Crohn’s Disease
… Atg16L1ΔIEC mice exhibited an enlargement of colonic goblet cells. In contrast, CD patients expressing *300A displayed smaller colonic goblet cells. Infected Atg16L1ΔIEC mice also exhibited colonic crypt atrophy and a reduced number of ileal villi; however there was no evidence of increased …
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SIGNALLING TISSUE RENEWAL AND CRYPT SURVIVAL IN THE HUMAN COLONIC EPITHELIUM AND BARRETT’S OESOPHAGUS
… a tightly regulated and controlled process. The colonic epithelium is organised into millions of invaginations called crypts, each of which represents the self-renewing unit of the tissue. In the mouse, renewal of the intestinal epithelium is regulated by signalling cross-talk between the Wnt, …
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Elucidating the role of Gremlin1 in colorectal cancer
… role in maintaining the architecture of the colonic crypt. However, despite these numerous reports, an in-depth understanding into the molecular mechanisms by which GREM1 regulates these processes remains elusive. <br/><br/>Using a series of in silico and in situ methodologies, we identified …
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CALCIUM SENSING RECEPTOR FUNCTION IN COLON: A ROBUST PROMOTER OF DIFFERENTIATION AND TUMOR SUPPRESSOR
… of calcium sensing receptor (CaSR) in the human colonic crypt epithelium is linked to cellular differentiation while its lack of expression is associated with undifferentiated and invasive colon carcinoma. Recent studies show that CaSR suppresses the malignant phenotype through a variety of …
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Messung der Zell-Zell Kopplung in Kolonkryptzellen der Ratte
Gekoppelte Zellen kommen nahezu überall im Körper vor und können mit Hilfe kommunikativer Zellkontakte eine Reihe von Funktionen erfüllen. So können die Zellen exokriner Drüsen durch die Kopplung über gap junctions als funktionelles Synzytium arbeiten. Auch die Kolonkrypte hat Eigenschaften, die …