Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Colon tumor"”.
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The Antitumor Agent, Arglabin-DMA, Preferentially Induces Apoptosis in Human Colon Tumor Cells
… the mechanisms by which Arglabin-DMA inhibits tumor growth <em>in vivo</em> and <em>in vitro</em> are still relatively poorly characterized. To determine the mechanism by which this drug inhibits tumor growth, the effects of Arglabin-DMA in two human colon tumor cell lines (mutant …
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Elucidating the Role of BMI1 in Lung and Colon Tumor Maintenance and Progression
… It is postulated that within heterogeneous tumor tissues, there exists a subpopulation of cells, termed cancer stem cells (CSCs), with the ability to initiate and support tumor growth, promote metastatic spreading, and drive relapse following chemoradiotherapy. Given the high tumorigenic …
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Mechanisms of Cell Death Initiated in Herpes Simplex Virus Thymidine Kinase Expressing Colon Tumor Cells Treated with Ganciclovir and UCN-01
<p>Metastatic colon carcinoma is the second leading cause of death from malignancy in the United States, and development of more effective treatments is essential. Heterologous expression of Herpes Simplex Virus Thymidine Kinase (HSVtk) in combination with the prodrug, ganciclovir (GCV), has shown …
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Dynamic Shuttling of AGO2 to the Nucleus Relieves MicroRNA Repression
… that three different model systems that mimic colon tumor microenvironments: (1) 2D colorectal cancer cell, HCT116, cultures grown beyond a monolayer to high cell density, (2) 3D HCT116 tumor spheroid cultures grown in collagen matrix, and (3) primary tissue samples from malignant colon tumor …
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SHORT-CHAIN FATTY ACIDS INDUCED AUTOPHAGY SERVES AS AN ADAPTIVE STRATEGY FOR RETARDING MITOCHONDRIA-MEDIATED APOPTOTIC CELL DEATH
… inhibit proliferation and induce apoptosis in colon cancer cells, but clinical trials had mixed results regarding the anti-tumor activities of SCFAs. Herein we demonstrate that propionate and butyrate induced autophagy in human colon cancer cells to dampen apoptosis whereas inhibition of …
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Protein L Functionalized Microparticles For Early Detection of Surface Markers In Heterogeneous Colorectal Lesions
… early detection. Increased understanding of the tumor landscape has identified surface antigens that can be utilized to distinguish normal and cancerous tissue lining the colonic lumen. Use of antibodies conjugated to nano/micromaterials offers a means to detect these antigens, however, the …
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Einschluss von 5-Fluorouracil (5-FU) in vesikuläre Phospholipidgele : in vitro und in vivo Untersuchungen zur Stabilität, Pharmakokinetik und antitumoralen Wirksamkeit
… der Arbeit sollte untersucht werden, ob die antitumorale Therapie mit 5-FU durch den Einschluss des Wirkstoffes in vesikuläre Phospholipidgele (VPG) im Vergleich zur konventionellen Therapie mit 5-FU-Injektionslösung effizienter gestaltet werden kann. Grundlage für die in vivo Versuche stellte …
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The Cellular and Molecular Dynamics of the Queuosine Modification in Transfer RNA: Definition, Modulation, Deficiencies and Effect of the Queuosine Modification System
… correlated with neoplastic transformation and tumor progression of a wide variety of cancers.</p> <p>The "normal" system for formation of the queuosine modification in tRNA was studied in human fibroblast cell cultures and in mouse, rat and human liver tissues. The queuosine modification system …
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Discovery of Anti-CD47 Peptides for Cancer Immunotherapy and CD47-mimicking Peptides That Inhibit Phagocytic Clearance of Nanoparticles
… adaptive immune system, generating T-cell antitumor responses. As critical innate immune cells, macrophages play important roles in homeostasis, preventing pathogen invasion, eliminating tumor cells, and promoting the adaptive immune system responses. Innate immune checkpoint inhibitors …
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CALCIUM SENSING RECEPTOR FUNCTION IN COLON: A ROBUST PROMOTER OF DIFFERENTIATION AND TUMOR SUPPRESSOR
… of calcium sensing receptor (CaSR) in the human colonic crypt epithelium is linked to cellular differentiation while its lack of expression is associated with undifferentiated and invasive colon carcinoma. Recent studies show that CaSR suppresses the malignant phenotype through a variety of …