Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Collective cell migration"”.
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Mathematical modelling of growth factor induced cell migration in 3D engineered matrices
Cells mechanically interact with their environment to sense, for example, topography, elasticity, mechanical cues from other cells, and chemical signals. Multi-signalling stimuli have profound effects on cellular behaviour, including migration. The current study aims to develop a mathematical model …
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Epidermal growth factor and Transforming growth factor α motogenic activities are mediated by Epidermal growth factor receptor : Identification of signalling pathways involved in head and neck cancer
… Growth Factor alpha (TGFα) to bind the extracellular domain of EGFR. Inhibition of this ligand binding blocks the activation of subsequent signalling pathways. It is known that not all Head and Neck cancers over-expressing EGFR respond to Cetuximab. It has been postulated that some of these …
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Regulation of the development and regeneration of the zebrafish posterior lateral line
Mechanosensory hair cells located in the inner ear mediate the sensations of hearing and balance. If damaged, mammalian inner ear hair cells are unable to regenerate, resulting in permanent sensory deficits. Damage to hair cells can arise from multiple factors such as high decibel and prolonged …
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Mechanical Regulation of Angiogenesis in a Biomimetic Model
Collective cell migration is required for numerous developmental and pathological processes including angiogenesis, branching morphogenesis, and cancer progression. Dynamic regulation of cell-cell adhesions, transmission of long-range contractile forces across cells, and remodeling of the …
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Directed Cell Migration: From Single Cells to Collectively Moving Cell Groups
… driven thermally by Brownian motion, eukaryotic cells move in a particular direction to accomplish designated tasks that are involved in diverse biological processes such as organ development and tumor progression. In this dissertation, I present experiments, analysis, and modeling of directed …
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Functional assessment of BRAF and CRAF through Base Editor 3 mutagenesis reveals residues and regions critical for ERK1/2 signalling
… pathway is critical for transducing extracellular signals from receptor tyrosine kinases at the plasma membrane through to protein targets to direct cell fate. Components of this pathway are frequently mutated to drive enhanced signalling in cancer and a group of developmental diseases …
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Continuum Models of Collective Migration in Living Tissues
… investigates the physical mechanics of collective cell migration in monolayers of epithelial cells. Coordinated cell motion underlies a number of biological processes, including wound healing, morphogenesis and cancer metastasis, and is controlled by the interplay of single cell …
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Problems in hard and soft matter: From brain folds and Levy localization to active elasticity
… tissue, which is composed of neurons, glial cells, and progenitor cells, we model an experiment (Theveneau) studying the dynamic interaction between neural crest cells and placodal cells in which the placodal cells run away from the neural crest cells following contact between the two. Our …
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The mechanisms underlying mechanical cell competition and leader cell migration in mammalian epithelia
Cell competition is a form of cell-cell signalling that results in the elimination of less fit cells from a tissue by their fitter counterparts. I take advantage of an established in vitro model of cell competition using Madin-Darby canine kidney (MDCK) cells to shed insight into the molecular …
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Stress Fiber Formation and Migration Are Novel PGR-Dependent Pathways Initiated in the Granulosa Cells of the Ovulating Follicle
… For ovulation to be successful, a series of intercellular events must be spatially and temporally coordinated throughout the ovarian follicle, culminating in rupture at the follicle apex and subsequent oocyte release. The nuclear steroid receptor, progesterone receptor (PGR) is a master-regulator …
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The Role of the YXXΦ Motif in CD82 Trafficking and Function
… found on the plasma membrane as well as in intracellular compartments, and CD82 undergoes endocytosis. The intracellular trafficking of proteins plays a key role in their functions. The mechanism by which CD82 is able to traffic remains not well known. Notably, CD82 contains an YXXΦ …
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Forces Generated by Cell Intercalculation Tow Epidermal Sheets in Mammalian Tissue Morphogenesis
… and individual movements—are processes of cell migration. Throughout our lives, cell migration plays a role in the maintenance and regeneration of our tissues, and even in the development and progression of disease. To carry out the complex tasks of development and tissue morphogenesis, …