Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Collateral sensitivity"”.
-
Collateral sensitivity and the evolution of drug resistance in Escherichia coli
Recently, collateral sensitivity networks have created excitement for designing new therapies that could reduce rates of evolution of antibiotic resistance in pathogens. To explore this idea, I tested the key assumption that collateral sensitivity should reduce the frequency of mutation to …
-
Rational drug combinations design against intratumoral heterogeneity and clonal evolution
… initial tumor composition, we sought to examine collateral resistance and sensitivity during clonal evolution. Using a murine model of Ph+ acute lymphoblastic leukemia, we performed drug selection and pharmacological screen experiments. We observed important evolutionary processes of selection …
-
Functional Interrogation Of Anti-Cancer Drug Resistance
<p>Targeted therapeutics are among the most promising approaches for treating diverse forms of malignancies. Indeed, as sequencing prices and technology continue to improve it will be possible to achieve a precise map of each individual cancer’s genomic lesions, providing insights into the best …
-
Investigating the Double-Edged Sword of Rifampicin Resistance in Mycobacterium Tuberculosis
… dynamics, cell wall and lipid composition, and collateral sensitivity to some antibiotics. RifR Mtb is known to evolve second site compensatory mutations in the α and β' subunits of RNAP that rescue the fitness of the strain to near Rif sensitive (RifS) levels. These compensatory mutations also …