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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Collagenases"”.
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The role of unfolded states in collagen degradation
… helix does not fit into the active site of collagenases, the enzymes responsible of cleaving collagen. Moreover, the scissile bond that is degraded during collagenolysis is hidden from solvent. Therefore it is widely agreed that collagen unfolding must occur in order for collagenolysis to …
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The mechanism of collagenolysis : a substrate-centric view
… suggests that the enzymes that degrade collagen, collagenases, physically unwind the triple-helical structure of collagen to gain access to the peptide bond that is cleaved. This unwinding mechanism would in principle have large energetic requirements, but neither ATP nor other energy-rich …
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Investigations into the digestive system proteases of Argiope aurantia (Araneae: Araneidae), hemolytic agents of spider venoms, and the role of both in necrotic arachnidism
… fibronectin. Having confirmed that the fluid has collagenases, the digestive fluid was injected into the skin of rabbits to observe whether it would cause necrotic lesions. It did not. The data do not support the suggestions that spider digestive collagenases have a primary role in spider bite …
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Elucidating Collagen Degradation Synergy between Col G and Col H from Hathewaya (Clostridium) histolytica and Identifying novel structural features in HPT and REC domains from VarS histidine kinase in V. alginolyticus
… by which Hathewaya (Clostridia) histolytica collagenases are secreted and work together to degrade collagens are investigated. While H. histolytica collagenases Col G and Col H have similar multi-domain structures the difference in number of and orientation of the domains hint that the two …
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Peptidazių iš Geobacillus thermoleovorans DSM 15325 kolagenolizinio aktyvumo analizė: M3 proteolizinių fermentų šeimos M3B pošeimio oligopeptidazės ir U32 proteolizinių fermentų šeimos peptidazės charakterizavimas /
… The determined constitutive production of collagenases by moderate thermophile Geobacillus thermoleovorans DSM 15325 confirms the ability of thermophiles to be ever ready for collagen uptake. The identification of constitutive collagenolytic peptidases variety produced by geobacilli lead to …
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The collagenolytic activity analysis of Geobacillus thermoleovorans DSM 15325 peptidases: characterization of M3 proteolytic enzymes family M3B subfamily oligopeptidase and U32 proteolytic enzymes family peptidase /
… The determined constitutive production of collagenases by moderate thermophile Geobacillus thermoleovorans DSM 15325 confirms the ability of thermophiles to be ever ready for collagen uptake. The identification of constitutive collagenolytic peptidases variety produced by geobacilli lead to …
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Collagen gene expression in human cancer
… and tumour cells indicated the presence of collagenases. The tumour cell conditioned media was subsequently shown by Western blot analysis to contain a protein of similar molecular weight to the tumour cell derived collagenase stimulatory factor (known as EMMPRIN or extracellular matrix …
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Multiscale models for the degradation, damage, and failure of collagen-based soft tissues
… time to mimic the action of strain-dependent collagenases. Mechanical failure and damage were modeled via the failure of discrete collagen fibers in a tissue based on a critical stretch criterion. Related research on the mechanical role of non-fibrillar matrix in tissues and on the mechanics …
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Selecting dietary-derived bioactives which protect cartilage from destruction in osteoarthritis
… an important role in cartilage degradation. The collagenases (MMP-1 and MMP-13) and aggrecanases (ADAMTS-4 and ADAMTS-5) are implicated in the development of OA because of their ability to degrade type 2 collagen and aggrecan. This project aims to identify compounds from the diet that could offer …
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Improving the delivery and efficacy of a cancer therapeutic via extracellular matrix modification
… a technique that is clinically applicable, human collagenases were screened for similar activity. Matrix metalloproteinase (MMP) -1 and -8 were identified as viable candidates and tested for their ability to degrade collagen and enhance diffusion in tumors. When overexpressed in tumors, neither …
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Histologic analysis of bone and teeth following enzymatic microdissection
Electronic Thesis or Dissertation
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Manipulating the mechanical strength and biological stability of collagen-based scaffolds for tissue engineering
… collagen is broken down by tissue/cell derived collagenases, which are members of the matrix metalloproteinase (MMP) family of enzymes. Angiotensin converting enzyme (ACE) inhibitors have long been used successfully to treat hypertension. More recently, some ACE inhibitors have also been shown …
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Untersuchungen zur extrazellulären Matrix unter Implantation differenter Netzmaterialien zum Bauchwandersatz
… which influences the different meshes on the collagenases MMP-1 and -13, their inhibitor TIMP-1, as well as the ratio of collagen Type-I to collagen Type-III have. It could be shown, that the size of the developing granuloma and so the extent of foreign-body reactions are dependent on …
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Migration of tumor cells and leukocytes in extracellular matrix : proteolytic and nonproteolytic strategies for overcoming tissue barriers
The extracellular matrix within connective tissues represents a structural scaffold as well as a barrier for motile cells, such as invading tumor cells or passenger leukocytes. It remains unclear how different cell types utilize matrix-degrading enzymes for proteolytic migration strategies and, on …