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Showing 1 to 7 of 7 for “"Collagen-Mimetic Peptides"”.
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Design of Collagen-Mimetic Peptides
<p>Collagen is the major component of the extracellular matrix and is involved in a wide range of cellular functions during tissue development and action. At the core of the diverse functions of this versatile protein is its remarkable ability to form supramolecular structures through self-assembly …
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Collagen-mimetic peptides for diagnosis and analysis
Collagen, the most abundant protein in the human body, is an essential scaffold for tissue development, regulation, and homeostasis. As a major structural component of the extracellular matrix, collagen is not static. Rather, it is highly diverse and dynamic, actively participating in tissue …
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Design, Structure and Applications of Collagen-Mimetic Peptides
The collagen triple helix is a unique protein fold found in all domains of life where is has diverse roles from imparting structure and strength to tissue, to initiating an immune response. While many factors affecting the structure and stability of the triple helix have previously been elucidated, …
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INVESTIGATION OF HETEROTRIMER-FORMING COLLAGEN-MIMETIC PEPTIDES THAT INCORPORATE AZA-GLYCINE RESIDUES
Collagen plays a critical role in both the structure and the function of the extracellular matrix, and its structure and expression patterns are dysregulated in a multitude of diseases. The canonical structural motif of collagen is a triple helix that is comprised either of three identical peptide …
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Stretching Collagen: Using Fluorophores in Collagen Mimetic Peptides as a Proposed Enantiomeric Sorting Technique
… universal, and some of them can be quite costly. Collagen mimetic peptides are naturally chiral and can exhibit reversible trimerization, making them attractive platforms for development of adjunct therapies. This research aims to create two fluorescent naphthalimide isomers to be embedded within …
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Damaged Collagen Detection and A Novel Approach to 1,3-Dipolar Cycloaddition Reactivity: Research at the Interface of Chemistry and Biology
Part I Chapter 1. Collagen Mimetic Peptides as a Selective Binder for Damaged Collagen. “Collagen diseases” were first introduced by Klemperer and coworkers in the 1950s. This type of disease can cause fibrinoid degeneration or changes in the collagen fibers that denature the collagen triple helix. …
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Improving Collagen-Mimetic Fibrils to Study Fibrillogenesis and Effects of Disease-Causing Mutations on Fibrillogenesis
<p>Collagen, the most abundant protein in the human body, serves as the scaffold of connective tissue and has biomaterial applications to promote wound healing. The need to study collagen further stems from a disease perspective, as mutations in collagen lead to numerous connective tissue diseases. …