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Showing 1 to 12 of 12 for “"Collagen type IV"”.
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Analysis of a Proposed Cell Binding Site on Caenorhabditis Elegans Collagen Type Iv
Collagen IV (col IV), a basement membrane protein, provides structural support and regulation of cell migration and binding. C. elegans body wall muscle col IV consists of two alpha 1 chains and one alpha 2 chain. The human col IV molecule has a cell binding site (CBS) composed of aspartate (D) on …
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Συσχέτιση της βιοσύνθεσης των βασικών μεμβρανών με την αγγειογένεση
… One of the basic structural elements of b.m. is collagen type IV which is found only in b.m. therefore there is a correlation between the biosynthesis of collagen type IV and so that of b.m. with angiogenesis. So the evaluation of the biosynthesis of collagen type IV can be used as a quantitative …
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Effect of Emb-9 and Let-2 Mutations on the Proper Assembly of Basement Membranes and on the Morphology of Body Wall Muscle Cells in Caenorhabditis Elegans
Collagen type IV is one of the most abundant components of the basement membrane composed of two α1 chains and one α2 chain secreted into the BM between muscle cells and the hypodermis early in embryogenesis. Worms homozygous for specific let-2 or emb-9 mutations show intracellular accumulation of …
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Potential roles for transforming growth factor-B during terminal differentiation of ocular lens cells /
… TGF-β is known as a regulator of both cell division and differentiation as well as a modulator of ECM production. Since TGF-β is found in the ocular environment and within lens cells, these functions of TGF-β in the lens were examined. In the avian lens, post-mitotic cells destined to become …
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Η ΒΙΟΣΥΝΘΕΣΗ ΤΩΝ ΒΑΣΙΚΩΝ ΜΕΜΒΡΑΝΩΝ ΩΣ ΒΙΟΧΗΜΙΚΟΣ ΔΕΙΚΤΗΣ ΤΗΣ ΑΓΓΕΙΟΓΕΝΕΣΗΣ
… AS PROLINE OR HYDROXYPROLINE, IN COLLAGEN TYPE IV, WHICH IS THE BASIC CONSTITUENT OF BM. COLLAGEN TYPE IV SYNTHESIS OF THE NEWLY FORMED BM WAS ESTIMATED EITHER BY MEASURING [U-14C]- HYDROXYPROLINE, OR BY MEASURING COLLAGENOUS PROTEIN DEGRADATION PRODUCTS, FOLLOWING DIGESTION WITH …
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Immunohistochemical analysis of a panel of human and murine markers on xenografted human vaginal mucosa: a comparative study
Athymic nude mouse models have been extensively used to study biological behaviour of normal and diseased human tissues. In such models, immune-deficient mice act as hosts for cysts constructed from human material. A unique biocyst model that entails transplantation of human vaginal cysts into …
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Notch Regulates Vascular Collagen IV Basement Membrane Through Modulation of Lysyl Hydroxylase 3 Trafficking
<p>Collagen type IV (Col IV) is a basement membrane protein associated with early blood vessel morphogenesis and is essential for blood vessel stability. Defects in vascular Col IV deposition are the basis of heritable disorders, such as small vessel disease, marked by cerebral hemorrhage and …
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Gene Expression in mESC Deficient in FGFR Signalling and the Identification of the Novel Gene Ened
Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of blastocyst stage embryos, and upon differentiation into embryoid bodies (EBs) they recapitulate the genetic, cellular and morphological events occurring in early embryogenesis. Among several signalling pathways and inductive …
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Development of a novel cell traction force transducer based on cholesteryl ester liquid crystals. Characterisation, quantification and evaluation of a cholesteryl ester liquid crystal based single cell force transducer system.
… of cells on LLC was due to the contractile activity of actin cytoskeletons that are mediated by focal adhesions. The staining experiments showed that cells consistently expressed the same suites of integrins (¿2, ¿3, ¿5 and ¿1) and ECM proteins (collagen type IV, laminin and fibronectin) on …
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The effect of inhibiting KPNB1-mediated nuclear import on cancer cell biology and inflammatory transcription factor signalling
… and mortality globally. Many novel and innovative approaches have been employed to develop new chemotherapeutic strategies, of which targeted therapies aim to identify a molecular lesion or dysregulated pathway that cancer cells are dependent on. Research in our laboratory and others identified …
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Molecular mechanisms of radiation-induced brain injury
… are no known successful treatments and effective strategies for mitigating radiation-induced brain injury. In addition, the specific mechanisms by which irradiation causes brain injury in normal tissues are not fully understood. A deeper understanding of the molecular mechanisms underlying …
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Die Bedeutung des Kollagenrezeptors α2β1- Integrin bei der Pathogenese und Prävention der Nierenfibrose in hereditären Typ IV- Kollagen- Erkrankungen
Kollagen Typ IV hat als einer der Hauptbestandteile von Basalmembranen eine Struktur gebende Funktion und ist als Ligand an Rezeptoren der Zelle bei der Vermittlung von Signalkaskaden, die Zellfunktionen, Wachstums- und Differenzierungsprozesse beeinflussen maßgeblich beteiligt. Aufgrund seiner …