Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"Collagen scaffolds"”.
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Biomechanical properties of engineered collagen scaffolds
… the effect of crosslinking on the stiffness of collagen scaffolds. Engineered non-crosslinked and dehydrothermally crosslinked chondroitin-6-sulfate collagen scaffolds were hydrated and loaded in tension, and their mechanical properties were compared. It was found that non-crosslinked scaffolds …
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Structure-functionality relationship of collagen scaffolds for tissue engineering
<p>Tissue engineering is a promising technology that enables scientists to create artificial organs or replace damaged tissues using animal cells and other components. For successful tissue regeneration, many factors should be taken into account, however, three components are most crucial: cell, …
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Architectural control of ice-templated collagen scaffolds for cardiac regeneration
… methods have been explored to produce biomimetic scaffolds to facilitate cardiac tissue regeneration. Ice-templated collagen scaffolds have demonstrated translational success in other clinical applications. The ice templating technique utilizes phase separation dynamics during solidification and …
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Collagen scaffolds and injectable biopolymer gels for cardiac tissue engineering
Three-dimensional biomaterial scaffolds have begun to shown promise for cell delivery for cardiac tissue engineering. Although various polymers and material forms have been explored, there is a need for: injectable gels that meet certain design specifications; a more indepth characterization of the …
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A comparative study of common crosslinking agents for electrospun collagen scaffolds
… immunogenic responses, causing graft rejection. Collagen is thus studied and used excessively as a successful implantable material. The reason being that it is natural in origin, biocompatible, bioresorbable, easily available and very cost effective. The current study involves electrospinning of …
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Fabrication and Optimisation of Collagen Scaffolds for Muscle Cell-Supported Angiogenesis
… essential for the success of tissue engineered scaffolds, facilitating appropriate oxygen, nutrient, and waste transport in structures larger than diffusion transport can achieve. Combining insights and priorities from the fields of tissue engineering and cultivated meat, this Thesis describes …
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Neural stem cell differentiation in collagen scaffolds for retinal tissue engineering
… (NSCs) were cultured in monolayer or in porous collagen scaffolds and exposed to neurogenic or non-neurogenic medium to determine the effects on neural differentiation and neurite growth. Nestin, [beta]III-tubulin, and GFAP expression were determined using immunofluorescent techniques, and the …
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Cell-seeded type II collagen scaffolds for articular cartilage tissue engineering
… engineering strategies employing cell-seeded scaffolds to treat such defects is the amount of cartilage formed in the construct prior to implantation. The objectives of this thesis were to evaluate effects of scaffold cross-link density and bioreactor culture environment on chondrogenesis in …
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Collagen scaffolds in full- and hemi- resection spinal cord injury models
… This thesis investigated the use of a porous collagen scaffold with aligned pores to serve as a substrate for axon guidance and a delivery vehicle for select therapeutic agents in both fulland hemi- resection injury models in adult rats. In the hemi-resection injury model, the treatment groups …
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Production and Characterisation of Tissue-mimicking Collagen Scaffolds for Cardiac Tissue Engineering
… approximate the material composition of the ECM, collagen type I can be used, as it constitutes the majority of the cardiac ECM in vivo. Furthermore, it can be easily extracted and processed, and offers a range of potential cell binding motifs. However, although its biophysical properties can be …
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The heterogeneous biochemical modification of porous collagen scaffolds for tissue engineering applications
… matrix is a complex and dynamic collection of collagens, non-collagenous matrix proteins, glycosaminoglycans and growth factors. The ECM plays a significant role in guiding the behavior of cells in their tissue specific niche. The recapitulation of both the mechanical and biochemical cues of …
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Modification of mineralized collagen scaffolds to overcome challenges of craniomaxillofacial bone repair
… supply. One such material is mineralized collagen scaffolds, which have many of the organic (type I collagen, glycosaminoglycans) and inorganic (calcium and phosphorous mineral) constituents of natural bone within a porous sponge. These materials can regenerate craniomaxillofacial defects …
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Design, Production and Characterisation of Anisotropic Collagen Scaffolds for Cardiac Tissue Repair
… success achieving this in tissue engineering scaffolds. Unidirectional ice-templating has been established in prior work and collagen structures with anisotropic porosity can be created via control of ice nucleation and growth. This thesis aims to advance knowledge using finite element …
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Collagen scaffolds for treatment of penetrating brain injury in a rat model
… injury, this thesis investigated the use of collagen biomaterials to fill a cavitary brain defect and deliver therapeutic agents. Characterization of the untreated injury revealed lesion volume expansion of 29% between weeks 1 and 5 post-injury. The cavity occupied parts of the striatum and …
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Gene-supplemented collagen scaffolds for non-viral gene delivery for brain tissue engineering
… The purpose of this thesis was to develop a collagen scaffold for the non-viral delivery of the gene encoding for Glial Cell-Derived Neurotrophic Factor (GDNF); hence to provide a local, long-term release and overexpression of GDNF via transfection of cells seeded into the scaffold or …
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Employing mineralized collagen scaffolds in a patient-centric approach for improved craniomaxillofacial bone repair
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Development of collagen scaffolds to address biomechanical design criteria for tendon–to–bone repair
… techniques. Herein we describe a variety of collagen biomaterials which incorporate local changes and patterns in composition to create multi-compartment and composite scaffolds for the purpose of orthopedic regeneration. We demonstrate that these biomaterials exhibit enhanced, locally …
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Ultrasound-assisted Ice Nucleation, Fibroblast Migration and Oxygen Delivery in Collagen Scaffolds for Tissue Engineering
Three-dimensional, porous collagen tissue engineering scaffolds can be produced using freeze-drying. However, the stochastic nature of ice nucleation may lead to architectural variability between structures created using nominally similar preparation conditions and this can impact subsequent tissue …
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Collagen Scaffolds for Tissue Engineering: The Relationship between Microstructure, Fluid Dynamics, Mechanics and Scaffold Deformation
Collagen scaffolds are porous structures which are used in bioreactors and in a wide range of tissue engineering applications. In these contexts, the scaffolds may be subjected to conditions in which fluid is forced through the structure and the scaffold is simultaneously compressed. It is clear …
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The Influence of Structure and Surface Biochemistry on Cell Function and Angiogenesis in Collagen Scaffolds
… following implantation. Ice-templated collagen scaffolds have been used in tissue engineering due to their bioactivity, tunable biodegradability and the ability to produce architectures with tailored porosity, but until now very little work has focused on vascularisation of these …
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