Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Collagen Scaffold"”.
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A Novel Biostable 3D Porous Collagen Scaffold for Implantable Biosensor
… glucose sensors, a new 3D porous and bio-stable collagen scaffold has been developed to improve the biocompatibility of implantable glucose sensors. The novel collagen scaffold was crosslinked using nordihydroguaiaretic acid (NDGA) to enhance biostability. NDGA-treated collagen scaffolds were …
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Metal-doped silicate microparticles for collagen scaffold-guided endochondral bone regeneration
… via direct, intramembranous ossification (IO), a collagen scaffold was shown to stimulate endochondral healing of large bone defects. Here, its unique intrinsic bioactivity relied solely on its architecture without the need for progenitor cell seeding or the application of growth factors. To …
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Design of an Electrospun Type II Collagen Scaffold for Articular Cartilage Tissue Engineering
… functional tissue. In this research, type II collagen was electrospun, cross-linked, and tested as scaffolds for supporting chondrocyte growth. The mechanical, biochemical, and histological characteristics of the engineered tissue were assessed as a function of the electrospinning solution …
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Measuring spatially varying elastic modulus of multi-compartment 3D collagen scaffold using indentation
Collagen scaffolds with discrete mineralized and non-mineralized regions that are joined by a continuous interface offer great potential for generating a platform with spatially variant stiffness. Once such platforms are seeded with cells, they have been shown to significantly influence cell …
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Investigation of a heirarchical collagen scaffold/3D printed lattice structure designed for use in total knee replacements
… of the construct. This contained a lyophilised collagen scaffold filling the lattice voids, to encourage osseointegration. To understand the effects of printing parameters on the structure and properties of prepared samples, the bonds formed between FDM printed rasters were explored. Samples …
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Multiscale Characterisation of Ice and Collagen: Physicochemical Development of Lyophilised Scaffolds for Tissue Engineering
… determine cellular response to ice-templated collagen-based constructs can be fine-tuned by modulating the scaffold fabrication process. To produce lyophilised scaffolds, ice crystals are grown in an aqueous collagen suspension then sublimed to create a highly porous and interconnected …
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Application of quantitative second-harmonic generation imaging to dynamic systems
… the 2 dimensional spatial orientation of collagen fiber samples under dynamic conditions. The technique is demonstrated both for a well aligned tendon sample and a randomly aligned, sparsely distributed collagen scaffold sample. For a fixed signal-to-noise ratio, the applicability of this …
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Characterization and Assessment of Lung and Bone Marrow Derived Endothelial Cells and their Bone Regenerative Potential
… EPCs were seeded to the fracture site upon a collagen scaffold. The in vitro studies displayed that the bone marrow and lung-derived endothelial cells presented EPC traits. In the mouse fracture model bone marrow, endothelial cells did not significantly improve the healing process. In the …
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Gene-supplemented collagen scaffolds for non-viral gene delivery for brain tissue engineering
… The purpose of this thesis was to develop a collagen scaffold for the non-viral delivery of the gene encoding for Glial Cell-Derived Neurotrophic Factor (GDNF); hence to provide a local, long-term release and overexpression of GDNF via transfection of cells seeded into the scaffold or …
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Collagen scaffolds for treatment of penetrating brain injury in a rat model
… injury, this thesis investigated the use of collagen biomaterials to fill a cavitary brain defect and deliver therapeutic agents. Characterization of the untreated injury revealed lesion volume expansion of 29% between weeks 1 and 5 post-injury. The cavity occupied parts of the striatum and …
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Fabrication and Optimisation of Collagen Scaffolds for Muscle Cell-Supported Angiogenesis
… essential for the success of tissue engineered scaffolds, facilitating appropriate oxygen, nutrient, and waste transport in structures larger than diffusion transport can achieve. Combining insights and priorities from the fields of tissue engineering and cultivated meat, this Thesis describes …
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Rapid 3-D laser microprinting of bioscaffolds and patterning of proteins
… of tissue engineering strategies use porous scaffolds containing chemical cues for culturing cells. However, these methods are unable to truly recapitulate the complexity of the in-vivo environment, limiting the effective regeneration. Several techniques have been developed to create …
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The human meniscus: transplantation, characterisation and tissue engineering
… meniscus cells with a CAM rich in type I collagen and aggrecan and lower quantities of type II collagen, while monolayer cultured meniscus cells have considerable amounts of type I and II collagen but almost no aggrecan in their CAM. Additional investigations led to the description of a …
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Multifunctional Polymer Fiber Probes for Biomedical Application
… microscale electroporation was observed in a 3D collagen scaffold (seeded with U251 human glioma cells) using fluorescent staining. Leveraging the scalable thermal drawing process, we envision a wide distribution of multifunctional polymer fiber probes in research facilities and hospitals. Along …
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Development of a nanoHydroxyapatite-collagen composite scaffold for bone tissue engineering
Scaffolds for tissue engineering must meet certain requirements to make it suitable for use as a bone graft substitute, including a three-dimensional and highly porous structure, with an interconnected pore network to facilitate cell growth and transport of nutrients and metabolic waste products. …
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Collagen scaffolds in full- and hemi- resection spinal cord injury models
… This thesis investigated the use of a porous collagen scaffold with aligned pores to serve as a substrate for axon guidance and a delivery vehicle for select therapeutic agents in both fulland hemi- resection injury models in adult rats. In the hemi-resection injury model, the treatment groups …
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Design, characterization, and reinforcement of mineralized collagen-glycosaminoglycan scaffolds for orthopedic wound repair
… This work outlines the development of a collagen-glycosaminoglycan platform that satisfies these requirements for the treatment of craniofacial defects. Chapter 2 details the fabrication and characterization of the collagen-glycosaminoglycan scaffold biochemical and biophysical properties …
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Engineering scaffold and soluble cues for cell-instruction
… approach that combines microenvironmental scaffold cues with soluble factor cues so as to enhance cell-instruction and tissue regeneration. In order for this aim to be accomplished, we started off by separately examining the control of microenvironmental cues and the regulation of soluble …
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Developing a medium-throughput collagen biomaterial model system
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Recapitulating mammary gland development and breast cancer cell migration in vitro using 3D engineered scaffolds
… by an adipocyte-rich fat pad, a highly collagenous extra-cellular matrix (ECM) and a number of other stromal and endothelial cell types. Mammary stem cells (MaSCs) reside within the epithelium and these are capable of repopulating a mammary fat pad that is devoid of epithelium, upon …
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