Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Collagen Fibrils"”.
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Mechanical behavior of individual type I collagen fibrils
… of studies on the mechanical response of collagen, especially at the molecular scale or at much larger length scales, such as of those of fibers, tendons, and fascicles, there is still limited information about the mechanics of collagen fibrils (50 - 500 nm diameter) that serve as …
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Time dependent mechanical behavior of mammalian collagen fibrils
Collagen fibrils, with dry diameters of the order of 100 nm, are the fundamental building blocks in connective mammalian tissues. While the mechanical behavior of tissues has been studied extensively and was shown to follow non-linear viscoelasticity, as similar quantitative understanding of the …
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Movement-induced orientation of collagen fibrils in cartilaginous tissues
Thesis (Sc. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1994.
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Crack propagation in bone on the scale of mineralized collagen fibrils: role of polymers with sacrificial bonds and hidden length
… using a simplified model of a mineralized collagen fibril sliding on a polymeric interface with SBHL systems. A 1D coarse-grained nonlinear spring-mass system is used to model the fibril. Rate-and-displacement constitutive equations are used to describe the mechanical properties of the …
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Development of Collagen Mimetic Mini-Fibrils with Tunable Collagenase Susceptibility
<p>Collagen fibrils are the primary molecular scaffold of all connective tissues and provide the essential support for cell migration and differentiation. Collagen fibrils represent one of the most complex molecular hierarchies: three polypeptide chains in Gly-Xaa-Yaa repeating amino acid …
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Aligned Fibrillar Collagen Matrices for Tissue Engineering
… cell behaviour for tissue regeneration. Aligned collagen fibrils were deposited on planar substrates from collagen solutions streaming through a microfluidic channel system. Collagen solution concentration, degree of gelation, shear rate and pre-coating of the substrate were demonstrated to …
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Scanning Probe Microscopy of Biomaterials and Nanoscale Biomechanics
… was utilized to systematically study individual collagen fibrils and cortical bone samples at the nanoscale with the focus on their mechanical and electromechanical properties. Furthermore, a new nanoneedle-based AFM technique was demonstrated to image soft materials such as membrane of living …
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Analyzing Interactions Between Cells And Extracellular Matrix By Atomic Force Microscopy
… long-term adhesion (90 minutes) to ECM proteins collagen-I and laminin-111. Interestingly, early adhesion (< 2 minutes) to laminin-111, was integrin-independent and instead mediated by carbohydrate interactions and galectins. In contrast, early adhesion to collagen-I was exclusively mediated …
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A Solid State NMR Investigation of Poly (ADP-ribose) and Its Involvement in Tissue Calcification
… that bind preferentially to the hole zones of collagen fibrils where mineralization is initiated. PAR mediates the biomimetic calcification of collagen fibrils in vitro in a periodic arrangement ofvi mineral density. The structure of PAR has been previously characterised by mass spectrometry …
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Structural Studies of the Corneal Stroma
… The stroma consists of lamellae of parallel collagen fibrils, of uniform diameter, embedded in a ground substance. It also contains glycosaminoglycans which are negatively charged at physiological pH. The organisation of the collagen fibrils and their relationship to the glycosaminoglycans …
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Ptychography for Nonlinear Optical Microscopy
… for the generation of a numerical sample of collagen fibrils, produce a set of numerical diffraction measurements. I introduce a novel Ptychography model for the simultaneous reconstruction of the components of the nonlinear optical susceptibility tensor and demonstrate the results of this …
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Scanning Probe Microscopy of Biomaterials and Nanoscale Biomechanics
… method is demonstrated through imaging single collagen fibrils in liquid as well as the extremely soft membrane of living cells under physiological conditions.
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Functional Biological Spectroscopy and Multiphoton Imaging Using Endogenous Optical Contrast
… to extracellular fluorescence, type I fibrillar collagen, was investigated with an in vitro model of collagen polymerization. By defining the fluorescence of collagen due to cross-linking and the structure of fibrillar collagen at a high resolution with second harmonic generation (SHG), sensitive …
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Elucidating Structure and Dynamics of Extracellular Matrix Collagen Using Solid-State NMR
… components at atomic-scale resolution. Fibrillar collagens are the most common component of the extracellular matrix (ECM), comprising up to 20% by weight of the human body and is found in most of the tissues. Due to their diverse structures and compositions, collagens serve many functions, …
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Nonlinear Viscoelastic Behavior of Ligaments and Tendons: Models and Experiments
… tendons. The mechanical behavior of bundles of collagen fibers which form ligaments and tendons was investigated. Axial stress-stretch data and stress relaxation data at different axial stretches were collected by testing rat tail tendon fascicles. The experimental results demonstrated, for the …
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Design of a novel anterior cruciate ligament prosthesis
… resembles (on a much larger scale) that of the collagen fibrils that naturally make up the ligament, using as a starting point the Comninou-Yannas crimped-fiber model.
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Structural Analysis of Reconstituted Collagen Type I - Heparin Cofibrils
… comprised of 2 native ECM components like collagen type I and the GAG heparin, is presented here. Although the individual components comply with the adhesive, mechanical and bioinductive requirements for artificial reconstituted ECMs, their interaction and structural characterization …
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Chondrocyte metabolism and matrix nano-electromechanics : the response to cartilage tissue shear deformation
… Proteoglycans are embedded within the network of collagen fibrils whose molecular structure (supercoiled helix of three alpha-chain subunits) provides resistance to tensile forces, and contributes to the overall poroviscoelastic behavior of the tissue. The dynamic balance between repulsive and …
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COORDINATED PHENOMENA IN THE MARINE DEMOSPONGE CHONDROSIA RENIFORMIS: PHYSIOLOGICAL, MORPHOLOGICAL, BIOMECHANICAL AND BIOCHEMICAL ASPECTS.
… spongin fibers and has a very conspicuous collagenous mesohyl mainly composed of collagen. This sponge can react to different stimuli by changing its tensile state: it can rapidly stiffen after mechanical or chemical stimulation or destiffen and, following accidental detachment of the …
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Systematic Interrogation of the Stiffness-sensitive Transcriptome in Mesenchymal Stromal Cells Reveals an Immunomodulatory LncRNA CYTOR
… of MSCs. High matrix rigidity impedes integrin-collagen adhesions which yields changes in cell morphology that are characterized by a contractile network of actin proximal to the cell membrane. This results in a suppression of extracellular matrix (ECM)-regulatory genes involved in the …
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