Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Collagen Crosslinking"”.
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The Role of The Epithelial-To-Mesenchymal Transition (Emt) In Lung Cancer Progression
… lung cancers. Our findings reveal increased collagen deposition in mesenchymal tumor tissues due to amplification of collagen gene expression in Zeb1-driven mesenchymal lung cancer cells. Additionally, collagen fibers in the metastatic tumor tissues exhibit greater linearity and organization, …
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Photoactivated Fixation of Cartilage Tissue
… has been postulated that effective transport and crosslinking of newly synthesized collagen molecules across a repair site may be vital to the process of integrative repair, and recent experiments have correlated collagen deposition with the strength of such repair. Other investigations have shown …
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Assessing the Biomechanical Properties of Cornea using Optical Coherence Elastography
… in situ after partial riboflavin/UV-A corneal collagen cross-linking using OCE; 4) rapid characterization of the biomechanical properties of porcine corneas before and after UV-induced collagen cross-liking at different intraocular pressures by OCE; 5) the development of method to differentiate …
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Investigation of a heirarchical collagen scaffold/3D printed lattice structure designed for use in total knee replacements
… of the construct. This contained a lyophilised collagen scaffold filling the lattice voids, to encourage osseointegration. To understand the effects of printing parameters on the structure and properties of prepared samples, the bonds formed between FDM printed rasters were explored. Samples …
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Quantification of Dynamic Epithelial Sheet Architecture in Botryllus Schlosseri Using 2-D & 3-D Image Analysis
… loss of barrier function, through (i) disrupting collagen crosslinking in the basement membrane using β-aminopropionitrile (BAPN); or (ii) disrupting the integrin pathway through inhibition of focal adhesion kinase (FAK). We performed stereographic projections of 3-dimensional high-resolution …
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Therapeutic targeting of the ATP7A copper transporter in cancer
… cell proliferation, cuproenzyme activity, and collagen crosslinking. Because Cu cannot be synthesized or metabolized by the body, it must be obtained through diet or supplementation. As a redox-active metal, Cu cycles between cuprous (Cu⁺) and cupric (Cu²⁺) states, making it a critical cofactor …
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Development of Cartilage-Derived Matrix Scaffolds via Crosslinking, Decellularization, and Ice-Templating
… cartilage proteins. This dissertation utilized collagen crosslinking techniques as well as ice-templating in order to enhance the mechanical properties of CDM scaffolds and prevent cell-mediated contraction. Furthermore, the decellularization of CDM was investigated in order to remove possible …
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Production of Compositional Analogues of Bone Based on Electrophoretically Deposited Mineralised Collagen Films
The mineralisation of collagen fibrils in bone at the nanoscale has a significant role in determining the properties of the tissue at the macroscale. The ability to reproduce this mineralisation in vitro offers the potential to provide insights into the highly complex process in vivo and has …
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Design and Analysis of a Collagenous Anterior Cruciate Ligament Replacement
… scaffolds comprised of reconstituted type I collagen fibers would have the potential to yield a more suitable treatment for ACL reconstruction. Ultra-violet (UV) radiation and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) were investigated as possible crosslinking methods for the …
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Gradients in Collagen Films: Effects of Mechanical and Chemical Properties on Directional Cell Response
… the creation of different types of gradients in collagen films and investigates their physicochemical properties and resultant cell behaviour. Crosslinking gradients were formed by gradual immersion of collagen films into different crosslinking solutions. The use of …