Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Colibactin"”.
-
An Investigation of Mutational Signatures in the Evolution of Oesophageal adenocarcinoma
… Barrett’s. Traces of BER (SBS30), MMR(SBS44) and colibactin associated signature (SBS41) were uncovered for the first time, as well as a platinum signature (SBS35). Mostly signatures increased in their proportions from Barrett’s to invasive tumours and further in metastasis. SBS17 showed strong …
-
Investigations of Carbapenem-resistant Klebsiella species and associated clinical considerations
… and rmpA (the regulator of mucoid phenotype) or colibactin are present in West London Hospitals. These are a cause for concern, as they have the potential to cause outbreaks that are untreatable. WGS analyses yield more accurate and comprehensive data compared with phenotypic testing, enabling …
-
Elucidating the Multi-omics of Early-Onset Colorectal Cancer
… SBS88 and ID18 (indicating DNA damage caused by colibactin-producing<em> pks+ E. coli</em>) and SBS17b (related to DNA damage caused by reactive oxygen species (ROS)) mutational signatures. Further metagenomics and transcriptomic analysis validated the mutational signatures and EORC. These …