Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 122 for “"Cohort Studies"”.
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Methods for handling missing data in cohort studies where outcomes are truncated by death
… addresses problems found in observational cohort studies where the repeated outcomes of interest are truncated by both death and by dropout. In particular, we consider methods that make inference for the population of survivors at each time point, otherwise known as 'partly conditional …
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Methodological considerations related to the epidemiologic study of birth outcomes: maternal ART use and adverse birth outcomes
… on this association comes from observational studies, which have previously given inconsistent findings. Accordingly, the overarching aim of this PhD was to reliably quantify the relationship between maternal ART use and adverse birth outcomes, by addressing the role of methodological factors …
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Association of socioeconomic status with incidence and mortality of heart disease and stroke in older people in China
… Methods: Two prospective community-based cohort studies were conducted in Anhui province and in four other provinces in China. The Anhui cohort consisted of a random sample of 3,336 older adults, of whom 1,736 aged ≥65 years recruited from urban areas in 2001 and 1,600 aged ≥60 years from …
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Radiation dose to the global flying population
… relative to being at sea level. Previous studies have assessed the radiation dose received in particular cases or for cohort studies. Here we present the first estimate of the total radiation dose received by the worldwide civilian flying population. We simulated flights globally from 2000 …
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Examining the Relationship Between Home Care Rehabilitation Therapy Services and Healthcare Utilization Among Those with Multimorbidity in Ontario, Canada
… dissertation addresses this aim through three studies: a rapid review and two retrospective cohort studies. The rapid review synthesized the existing literature about home care rehabilitation therapy services for individuals with multimorbidity. The key findings from this review were that …
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Investigating the association between sleep quality and depressive symptomatology in post-secondary students
… university students. Methods: I conducted two studies of post-secondary students. First, I systematically reviewed the literature on the association between poor sleep quality and depressive symptomatology. Second, I measured the cross-sectional association between poor sleep quality and …
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Joint models for longitudinal and survival data
Epidemiologic and clinical studies routinely collect longitudinal measures of multiple outcomes. These longitudinal outcomes can be used to establish the temporal order of relevant biological processes and their association with the onset of clinical symptoms. In the first part of this thesis, we …
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Delay in accessing healthcare after transient ischaemic attack and minor stroke : the role of primary care in the problem and the solution
… to contact healthcare services. However, using cohort studies to answer questions on healthcare access requires an assessment of how well such cohorts represent the wider population. Within the primary care consultation, the recognition of TIA is an important step in the care pathway as …
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Blood Lead and Decision Speed in Working Age Adults
… findings, if confirmed by case control and or cohort studies would indicate a need to reconsider currently accepted lead levels in working age adults.
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An investigation of basic science and clinical research methodologies to benefit clinical practice
… to treat menstrual abnormalities using clinical cohort studies. Furthermore, Chapter 2 highlights how negligence in female sterilization failure may be mathematically (Bayesian) modelled. Chapter 3 explores the value of systematic reviews for preventing preterm delivery and use of LNG-IUS (Mirena …
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Decision value of confidence intervals versus significance testing in surgical research: a mixed methods study
… in usefulness to meta-analyses and prospective cohort studies. The term “significance” was found to be a noisy term and had a subjective meaning based on the reader’s interpretation. Significance testing and confidence intervals were rated to have the same value. When comparing the informal …
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An exploratory analysis of large health cohort study using Bayesian networks
Large health cohort studies are among the most effective ways in studying the causes, treatments and outcomes of diseases by systematically collecting a wide range of data over long periods. The wealth of data in such studies may yield important results in addition to the already numerous findings, …
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Vascular contributors to cognitive impairment and dementia: insights from existing data
… and its gradual progression, longitudinal studies are essential not only to track disease trajectories over time but also to identify individuals at risk as early as possible for potential recruitment into future interventions. Despite their importance, long-term follow-up in cohort studies …
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Statins and Risk of Alzheimer Disease: A Systematic Review and Meta-Analysis
… to identify all available published prospective studies that evaluated the effect of statin treatment on the incidence of Alzheimer disease in individuals with normal cognitive function at baseline. After the relevant studies were identified, a meta-analysis was conducted. A random-effects model …
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Population strategies to decrease sodium intake : a global cost-effectiveness analysis
… randomized controlled trials, prospective cohort studies, meta-analyses, and simulation models that together constitute the evidence base for public health recommendations on sodium intake, as well as for this study's own analysis. These methodological issues, some raised for the first …
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Safety and Effectiveness of Cecal Retroflexion in Evaluating Proximal Colon: A Case Series
… METHODS: We performed retrospective cohort study of all patients age 18 to 85 years who received colonoscopy by one endoscopist at UT Southwestern Medical Center from 9/1/2006 to 7/31/2012.We excluded patients who received colonoscopies prior to the initiation of cecal retroflexion, …
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Infrastructure Development For Personalized Risk Prediction to Reduce Cardiovascular Disease In Childhood Cancer Survivors
… therapy (RT) has been linked in numerous cohort studies to a higher chance of developing a late cardiac disease in these survivors, and this risk rises with higher mean heart doses and increased RT exposure to larger cardiac volumes. Since, the heart is a heterogeneous organ made up of …
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Proteomic insights into the modulation of foetal neurogenesis by the anti-retroviral efavirenz
… linked to birth defects such as encephalocoele. Cohort studies of HIV-uninfected children exposed to antiretroviral treatment in utero report minor learning delays but are inconclusive. Non-transformed human derived neuroepithelial stem (NES) represent a unique pre-clinical model in which to …
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Making an impact in public health through philanthrocapitalism : the PaCT Project and ImPaCT Commercial Ventures
Large-scale epidemiologic longitudinal cohort studies are a distinct area of epidemiology and public health. To conduct such studies, it often requires exorbitant resources. African collaborators and a team of Harvard scientists have initiated what is groundbreaking to the field of epidemiology and …
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A longitudinal examination of the impact of self-esteem on alcohol use in untreated heavy drinkers
… from the Birmingham Untreated Heavy Drinkers cohort. This dataset had repeated measures of multiple measures of alcohol use, self-esteem and other sociodemographic and clinical variables of interest. The results of the multiple linear regression models suggested that over time heavy drinkers …
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