Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Cognitively Normal"”.
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Sex Differences in Alzheimer’s Disease Neuroimaging Biomarkers among Cognitively Normal Older Adults
… study aimed to examine sex differences in cognitively normal older adults on: (1) Amyloid-β on 18F-AV-45 Florbetapir PET imaging (2) neurodegeneration via T1 weighted MRI volumetrics, (3) cerebral blood flow via ASL-MRI. We identified genetic (APOE genotype status) and medical (fasting …
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The Relationship Between Neuropsychological Functioning, Biomarker AV-1451, and Subjective Memory Impairment in a Cognitively Normal Sample
… structures. The sample included 127 cognitively normal (CN) participants, selected from the Alzheimer’s Disease neuroimaging Initiative 3. Participants were cognitively normal, free from co-morbid disorders such as depression, and included individuals who had undergone PET imaging at …
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Elucidating the Impact of Previous Head Injury on Cognition, Brain Structure, and Pathophysiology in Cognitively Normal Individuals Across the Adult Lifespan
Mild traumatic brain injury (mTBI), or concussion, is a common experience and awareness of mTBI has been increasing. There has been growing concern regarding potential long-term effects of concussion on cognition and risk for neurodegenerative disorders. This concern is heightened for athletic …
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Metering Mood with Veggies: Association of skin carotenoid levels and depressive symptoms or mood disturbances
… and depressive symptoms or mood disturbances in cognitively normal older adults. Design: Baseline data were collected from 109 cognitively normal men and women ages 65 years and older from the Nutrition Interventions for Cognitive Enhancement (NICE) cohort study. Skin carotenoid status was …
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Intraindividual Variability as a Correlate of White Matter Decline
… dissertation examined two aims on a group of cognitively normal and early-stage AD participants. Based on previous literature, the first aim examined evidence for a double dissociation between aspects of cognitive performance and neuroanatomical structure, such that the coefficient of …
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Hippocampal Volume and the Detection of Mild Cognitive Impairment in an Older Adult Population: Assessing Performance on Cognitive Screeners Administered In-Person and Electronically
… met criteria for diagnostic classifications of cognitively normal and mild cognitive impairment and had undergone neuropsychological testing consisting of the Montreal Cognitive Assessment and Cogstate Brief Battery, as well as structural magnetic resonance imaging scans of the hippocampus at …
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Identification of Novel Fluid Biomarkers for Alzheimer's Disease
… 47 proteins that differed in abundance between cognitively normal: Clinical Dementia Rating [CDR] 0) and mildly demented: CDR 1) subjects. To validate these findings, we measured a subset of the identified candidate biomarkers by enzyme linked immunosorbent assay: ELISA); promising candidates in …
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Predicting the level of cognitive function from standing balance and salivary biomarkers
… of participants were categorised by the MoCA as cognitively impaired, and 22% of participants (with 11.6% being cognitively impaired) perceived the MoCA as ‘very stressful’ or ‘stressful’. In eyes open and closed conditions and all foot positions, good-to-excellent relative reliability (ICC = …
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Proteomic-based Signature of Brain-related Proteins as Novel Candidate Biomarkers for Alzheimer’s Disease Diagnosis
… tau protein levels are changed relative to cognitively normal elderly. There is a need for novel disease-specific biomarkers that will capture disease more accurately and at an earlier stage, predict disease severity, and be used in research and clinical trial settings for patients’ …
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Fine Particulate Matter, Neuropathologies, & Dementia
… disease. Our analyses indicated that, among cognitively normal individuals, a 5 ug/m3 increase in 1-yr and 7-day PM2.5 exposure was associated with elevated VCAM-1 (beta (95% CI) for 1-year: 51.8 (6.5, 97.1) ng/ml; 7-day: 35.4 (9.7, 61.1) ng/ml) and that a 5 ug/m3 increase in 1-yr PM2.5 …
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A Novel Cognitive Stress Test for the Detection of Early Alzheimer’s Disease in African Americans
… to clinicians who must differentiate between normal aging and progressive neurocognitive conditions (Celsis, 2000; Sherwin, 2000). As targeted therapeutic interventions and emerging therapies for AD are much more likely to be effective in the earlier stages of the disease (Loewenstein, Curiel, …
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Evaluating the Efficacy of Detection Instructions on Additive and Contradictory Misinformation in Older and Younger Adults Using Eyewitnessed Visual Scenes
… effects were evaluated by comparing groups of cognitively normal older adults to younger adults given older adults often show declines in controlled attentional processes that can compromise episodic memory and to produce larger misinformation effects. Finally, my thesis utilized video …
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Behavioral and neural investigations of value-directed strategic processing
… value on value-directed strategic processing in cognitively normal younger and older adults, and older adults with mild cognitive impairment. Chapter 1 reviews historical perspectives and paradigms related to selective attention and behavioral and neuroimaging literature related to value-directed …
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ARTERIAL STIFFNESS AND CEREBRAL BLOOD FLOW AMONG OLDER ADULTS
… a significant association with lower CBF among cognitively impaired individuals. This relationship was not significantly different among cognitively normal individuals. Reflection magnitude was significantly associated with poorer cognitive performance on Language and Processing Speed domains …
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Epigenetic Regulation of Neurogenesis in Non-Demented Humans with Alzheimer’s Disease Neuropathology
… hallmarks of the full disease but are cognitively normal. To investigate the microRNAs of interest in the correct context, as microRNA expression can vary significantly by region, the granular cell layer and the subgranular zone were microdissected from the same subjects investigated …
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The Master Synaptic Regulator: Activity Regulated Cytoskeleton Associated Protein, Arc, in Normal Aging and Diseases with Cognitive Impairment
… spines. AD pathologies can be found in brains of cognitively normal elderly individuals. Together with the fact that synaptic activity is altered during aging and markedly deteriorated in AD, we therefore hypothesize that altered basal and activity-driven Arc expression contribute to deleterious …
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The Neural Correlates of the Age-Related Decrements in Selective Attention That Occur in Healthy Cognitive Aging: an FMRI Study of the Stroop Task
… with functional MRI scans. We recruited 60 cognitively normal participants from 40-90 years of age, with 12 participants within each decade group. We found that the bilateral Middle Frontal Gyrus (MFG) was the only area to exhibit unanimous, linear age-associated declines in activity amongst …
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Neuropsychological Functioning in Aging National Football League Retirees
… comprehensive neuropsychological evaluations. Cognitively normal retirees (n = 26) were age, education, and IQ-matched to healthy controls (n = 26). Retirees diagnosed with MCI or dementia (n = 27) were matched as closely as possible to a clinical sample of patients with MCI and dementia by …
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Explaining Racial Discrepancies in Verbal Memory Assessment with Joint Estimation of Life Course Social Inequalities and Measurement Bias
… of the approach. Utilizing a sample of 2074 cognitively normal adults over the age of 65 who identified as either racially White or Black, the pervasive bias model revealed that race had minimal direct contributions to measurement bias. In contrast, educational attainment was found to cause …
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Lipidomic Dysregulation in Alzheimer's Disease: Relation to Genetics, Neuroimaging and Other Biomarkers
… their fatty acid composition. Diagnostic groups (cognitively normal older adults (CN), mild cognitive impairment (MCI), and AD) differed on two principal components extracted from 84 serum TG levels. Fish oil-type and olive oil-type TGs were significantly lower in MCI and AD compared to CN. Next, …
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