Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 264 for “"Cognitive Decline"”.
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Predicting Cognitive Decline in Older Adults
… tests are more likely to predict an individual’s cognitive decline (i.e., normal to mild cognitive impairment, mild cognitive impairment to Alzheimer’s disease) two years prior to conversion. A sample of non-decliners (N=109) compared to those who declined (N=24) in cognitive status (i.e., mild …
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Modeling Post Stroke Respiratory Dysfunction, Apneas and Cognitive Decline
… Dysfunction,</strong></p> <p><strong>Apneas and Cognitive Decline</strong></p> <p>Anthony Patrizz, B.A.</p> <p>Advisory Professor: Louise McCullough M.D., Ph.D.</p> <p>Stroke is a major cause of mortality and the leading cause of long-term disability in the US. More than 60% of individuals …
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Moderation of age-related cognitive decline in older adults
Prior research has demonstrated a general decline in cognitive performance with age, especially in Fluid Intelligence. This study sought to find a way to slow, halt, or reverse the age-related decline in Fluid Intelligence. Participants aged 50 and older with no prior experience working crossword …
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Identifying Factors Underlying Resilience to Age-Related Cognitive Decline
… episodic memory abilities can exhibit early declines. Evidence suggests that distinct components of episodic memory retrieval may be differentially impacted by age. In particular, the precision of memories shows detectable declines as early as midlife, whereas the ability to successfully …
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Memory Fidelity in Healthy Ageing and Risk for Cognitive Decline
Memory decline is characteristic of cognitive ageing and it has been suggested that one important factor underpinning the magnitude of age deficits is a reduction in the fidelity or quality of perceptual and mnemonic representations. This thesis examined cognitive and neural underpinnings of …
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Genetic determinants of rates of cognitive decline in preclinical Alzheimer’s Disease
… and, amongst these, those that are expected to decline over the course of a trial. While brain imaging to determine Aβ- amyloid burden has utility in identifying individuals with preclinical AD, further work needs to be conducted to determine what influences rates of change during these early …
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Cardiovascular diseases, risk factors and cognitive decline in the general population
Cognitive function constitutes a critical dimension of the health status of elderly individuals. Age-associated decline in cognitive function may partly be attributed to the negative effects of systemic medical diseases and related factors, including cardiovascular diseases (CVDs) and vascular risk …
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COGNITIVE DECLINE WITH AGE: ROLE OF STRIATAL CHOLINERGIC SYSTEM AND GROWTH HORMONE
Normal aging can result in cognitive decline even in the absence of neurodegenerative disease. Successful identification of neurobiological changes that occur in association with age-related cognitive decline is needed to develop strategies to restore or preserve cognitive function in elderly …
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Input and output order of recall as early markers of cognitive decline
… older individuals and in older adults with cognitive decline. In study 1 (Chapter 4), primacy (intended as the tendency to better remember items presented at the beginning of a list compared to the middle) at delayed recall was the most accurate serial position effect in predicting …
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Lexical-semantic parameters as robust endophenotypes of abnormal cognitive decline in ageing
… differences in cross sectional performance and decline of semantic-lexical abilities and to investigate whether these linguistic effects indicating semantic degradation are sensitive indicators of medial temporal atrophy in early Alzheimer's disease and in patients with mild cognitive impairment …
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Prediction model for cognitive decline in older adults living in the community
INTRODUCTION: Because of rapid population aging cognitive decline and dementia in the older population are recognized as major public health problems. The purpose of this study was to identify demographic, health behavioral, medical and genetic factors associated with cognitive decline; and to …
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Cortisol and inflammation in delirium and long-term cognitive decline after hip fracture
… of delirium, persistent delirium and cognitive decline following delirium. It investigated whether levels of cortisol in blood and cerebrospinal fluid (CSF) are elevated in delirium, with elevated pro-inflammatory and reduced anti-inflammatory cytokines. It also investigated whether …
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Using Genetic Diversity to Understand Susceptibility to Cognitive Decline in Aging and Alzheimer’s Disease
… important role in determining susceptibility to cognitive aging and transition to dementia such as Alzheimer's disease (AD). Identifying the specific genetic variants that contribute to cognitive aging and AD may aid in early diagnosis of at-risk patients, as well as identify novel therapeutics …
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Using EEG to investigate premature aging and cognitive decline in adults with Down's Syndrome
… preclinical stages, with the goal of preventing cognitive decline in the first place, rather than trying to halt or reverse existing pathology. Consequently, it has become essential to develop biomarkers of AD, which can: 1. Predict clinical changes and 2. Track the effectiveness of putative …
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Effects of Stress, Sex Differences, and Cognitive Reserve on Cognitive Decline in Healthy Elderly Subjects
… it may be possible to similarly predict risk of cognitive impairment. To test this, the current study explored the cumulative effect of discreet psychosocial stressors that have occurred within the past year and their effect on changes in cognitive functioning as measured by individuals’ …
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Subjective cognitive decline and related worry: Examining biopsychosocial correlates in mid-age and older Canadians
Introduction: Subjective cognitive decline (SCD), a self-reported decline in cognition in otherwise cognitively healthy people, has been acknowledged as a risk factor for Alzheimer’s disease. Using data from the Canadian Longitudinal Study on Aging (CLSA), a large national study with participants …
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Identify Signature Genes/Pathways to Characterize Alzheimer's Disease Subtypes Based on Uncoupled Tauopathies and Cognitive Decline
… unmatched tauopathy progression with their cognitive decline. A detailed study on these so-called atypical AD patients allows for a deeper understanding of possible various disease mechanisms and the factors contributing to disease vulnerability or resilience, which can help guide the drug …
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Validation of the Mild Behavioral Impairment-Checklist in Subjective Cognitive Decline, Mild Cognitive Impairment and Dementia
… (NPS) are early markers of dementia preceding cognitive impairment. The Mild Behavioral Impairment Checklist (MBI-C) was developed to characterize NPS for pre-dementia patients. This thesis examines the validity and utility of the MBI-C for detecting neuropsychiatric symptoms in relation to …
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