Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Cofilin 1"”.
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Analisi Molecolare del Melanoma
… A ¿ isoform, protein DJ-1, cyclophilin A and cofilin-1. We show, for the first time, that only specific isoforms of these molecules are overexpressed in melanoma. Different protein profiles were also found between each individual melanoma cell line and the melanocytes. s-Methyl-5-thioadenosine …
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Investigation of Nonhydrolyzable ATP Analogues and Cofilin-Derived Peptides for Inhibition of Cofilin-Actin Rod Formation
Actin-Cofilin rods are an important marker of neurodegenerative disease and are commonly observed in the neurons of patients with Alzheimer's disease. The goal of this research is to investigate peptide and small-molecules for their potential to inhibit actin-cofilin rod formation in cells. These …
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The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity
… a bacterial II hybrid assay, we also identified cofilin 1 as a novel protein partner of WT1. Our data also indicate that BCR/ABL1 induce expression of the WT1 gene via the phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway in the leukemic cell line K562. Given our finding that WT1 …
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Modulation of the aquaporin-2 localization in renal principal cells
… by activating the actin-depolymerizing protein cofilin-1 (CFL1). In contrast, alisertib promoted the formation of the actin barrier. Alisertib did not affect the CFL1 activity and must thus control the actin cytoskeleton and the AQP2 localization via different mechanisms. The second part builds …
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The Role of Rac1 in Synaptic Plasticity, Learning and Memory
… significant reduction in p-PAK-1, p-LIMK-1 and p-Cofilin-1, all proteins downstream of Rac1 and essential for cytoskeletal rearrangements leading to dendritic spine development. In order to evaluate the involvement of Rac1 in long term synaptic plasticity (LTP and LTD), hippocampal slices from age …