Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Coexpression"”.
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Architecture and Evolution of Xylem-related Gene Coexpression Networks in Poplars
With the advent of sequencing technologies, a variety of methods have been available day by day. Each of these methods have helped scientists to for a deeper understanding of the biological function and evolutionary constraints on the relevant genes, which can be gained through the use of modern …
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Systemic analysis of changes in protein modification and gene coexpression networks in cancer
… normal tissues, enabling us to calculate gene coexpression networks and apply graph algorithms in Neo4j.
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Evolutionary fingerprints in genome-scale networks
… evolutionary fingerprints in metabolic and gene-coexpression networks is the central topic of this cumulative thesis based on four published articles. An understanding of the actual origin of life will probably remain an insoluble problem. However, one can argue that after a first simple …
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Identification of Previously Unknown Interactions Between G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins
… interactions, we first investigated the global coexpression and coevolution between GPCRs and RAMPs. On the one hand, if many GPCRs interact with RAMPs we would except to see statistically significant coexpression and coevolution in comparison to random gene pairs. On the other hand, if …
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Design of a microscopy-based screening method for stomatal development genes in <i>arabidopsis thaliana</i>
… cell development. It was hypothesized that gene coexpression analysis would facilitate identification of gene candidates involved in stomatal development. Plants harboring mutations in the candidate genes were analyzed to detect a stomatal phenotype, using dental resin impressions and light …
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Ligand induzierte Phosphorylierung des Chemokin Rezeptors CCR5: strukturelle Analyse und Funktion
… Bedingungen Homodimere bildet. Durch Coexpression zweier CCR5-Mutanten mit unterschiedlichen Defekten in ihrer Rezeptoraktivierbarkeit konnte die Funktion beider Rezeptoren wieder hergestellt werden. Daher läßt sich postulieren, daß Homodimere in der Signaltransduktion vermutlich als …
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Catalytic promiscuity of two plant P450 enzymes: CYP725A4 from Taxus cuspidata and CYP71B102 from Isatis Tinctoria
… by matching mass spectra from previous studies. Coexpression of CYP725A4 with cytochrome P450 reductase, CPR (as either fused or separate proteins) and cytochrome b5 (Cb5) did not affect the ratios of OCT, iso-OCT, and T5α-ol, although Cb5 had an apparently negative impact on CYP725A4 activity. …
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Annotating Human Interactome to Predict Pathways and Systematically Analyzing Network Rewiring in Cancer across Multiple Tissues
… thirty-five cancer types. I used pairwise gene coexpression and differential coexpression to annotate 276,552 PPIs with tissue- and cancer-specificity. Pan-cancer comparison of annotated PPIs provides novel insights toward dynamics of PPI networks in tissue-cancers. We found that while PPI …
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Beteiligung der Phospholipase D an der Regulation der Synthese von Phosphatidylinositol-4,5-bisphosphat durch Arf- und Rho-GTPasen
… PIP2 synthesis was completely blocked by coexpression of catalytically inactive Arf1 T31N. Reversely, the effect of constitutive active Arf1 Q71L was fully inhibited by catalytically inactive PLD constructs. Whereas the effects of Arf1 Q71L and wild-type PLD2 were additive, coexpression of …
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IMMUNOPROFILE IN EFFUSION CYTOLOGY
… canine and feline results. Vimentin/cytokeratin coexpression had a sensitivity of 79% and a specificity of 92%, HBME‐1 had 89% sensitivity and 23% specificity, and CK5/6 had 26% sensitivity and 100% specificity for mesothelial cells. Desmin had only 20% specificity for benign mesothelial cells, …
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Identification of gene expression changes in human cancer using bioinformatic approaches
… expression platforms increases reliability of coexpression predictions. However, I also observed that global correlation between platforms was generally low, and few gene pairs reached reasonable thresholds for high-confidence coexpression. Therefore, I developed a novel subspace clustering …
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GENETIC DISSECTION OF AVERSION TO ALLYL ISOTHIOCYANATE IN Drosophila melanogaster
… in the periphery to determine if there was any coexpression between these two receptors. We observed an absence of colocalization in sensory cells in the legs. We also expressed UAS-ORK, which electrically silences cells, in sensory neurons, to evaluate the necessity of dTRPA1 and painless cell …
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Identification And Characterization Of The Major Gene Ma And Its Associated Co-Expression Gene Networks Regulating Apple Fruit Acidity
… aims at identification of the Ma1 associated coexpression gene network regulating malate levels in developing fruit of Golden Delicious and was reported in Chapter 3. One finding of this chapter is that malatepyruvate interconversion, photosynthesis, mitochondrial electron transport, and amino …
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Polony sequencing : DNA sequencing technology and a computational analysis reveals chromosomal domains of gene expression
… on the same chromosome often show significant coexpression. This coexpression is independent of the orientation of genes to each other, but is dependent on the distance between genes. In several cases where adjacent genes show highly correlated expression, the promoter of only one of the genes …
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SNARE specificity in membrane protein traffic
… response activated during slide preparation. Coexpression of KAT1 with SYP121-Sp2, SYP122-Sp2 and SYP71-Sp2 resulted in a disruption of trafficking and in microdomains becoming diffuse and mobile at the plasma membrane. No disruption in trafficking or localisation of KAT1 was seen when …
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Novel findings on cellular trafficking and targeting for granule storage of neutrophil elastase, a multifunctional effector molecule of innate immunity
… between the tetraspanin CD63 and proNE upon coexpression in COS cells. Furthermore, depletion of CD63 in a promyelocytic cell line (achieved by RNA interference or a CD63 mutant) caused reduced processing of proNE into mature NE and reduced constitutive secretion of proNE. We therefore …
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Molecular genetics of the imprinted gene - SPROUTY3 (SPRY3)
… an AG-rich repeat and we found evidence of coexpression, promoter binding and regulation of SPRY3 expression by transcription factors EGR1, ZNF263 and PAX6. Spry3 over-expression in mouse superior cervical ganglion cells inhibits axon branching and Spry3 knockdown in those cells increases …
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The Role of CDCA7 in Akt-mediated Myc-Dependent Apoptosis and Proliferation
… to 14-3-3 and sequestration in the cytoplasm. Coexpression of CDCA7 and Myc in fibroblasts potentiates Myc-dependent apoptosis upon serum withdrawal. In contrast, knockdown of CDCA7 by shRNA abrogated Myc-dependent apoptosis. Myc induced transformation of fibroblasts was reduced in the presence …
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Creg1 And Its Enhancement Of P16ink4a-Induced Senescence
… is also downregulated in immortal cells and that coexpression of CREG1 and p16INK4a, an inhibitor of CDK and Rb phosphorylation, has a greater effect than CREG1 or p16INK4a alone to reduce cell growth, to induce cell cycle arrest and cellular senescence in immortal LFS, osteosarcoma and …
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The Intracellular Domain of EPHB1 Is Required for Axon Pathfinding at the Optic Chiasm and Corpus Callosum
… axon guidance at the optic chiasm despite the coexpression of EphB2 in the same ipsilaterally projecting RGC axons. In addition to analyzing the axon pathfinding defect at the optic chiasm, the EphB1 T-lacZ mice were also used to analyze another phenotype associated with EphB1 -/-protein-null …
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