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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"Coenzyme A"”.
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Studies on the Mechanism of Isomerization of Methylmalonyl-Coenzyme-a to Succinyl-Coenzyme-a
Made available in DSpace on 2014-12-05T17:47:53Z (GMT). No. of bitstreams: 1 6402877.pdf: 3207452 bytes, checksum: 0fd6f933a02fa70a200d8818a985de18 (MD5) Previous issue date: 1963
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Targeting Coenzyme A Biosynthesis for Antifungal Development.
… drugs with improved clinical efficacy.</p> <p>Coenzyme A (CoA) is a universal and essential cofactor for several key metabolic pathways including fatty acid oxidation and synthesis, the tricarboxylic acid cycle, and sterol biosynthesis. Nearly all organisms must synthesize their own CoA from …
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Studies on the Regulation of Hepatic Hmg Coenzyme a Reductase and the Production of Anti-Hmg-Coenzyme a Reductase Monoclonal Antibodies
Rat liver and Chang liver cells have been adapted to growth in serum-free chemically defined Higuchi's medium for the purpose of studying the regulation of HMG-CoA reductase.
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Phosphoryl-Coenzyme A, an Intermediate in Enzymatic Succinylation of Dihydrolipoic Acid
Made available in DSpace on 2015-05-12T17:02:37Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 0025286.PDF: 2989149 bytes, checksum: 555c748895855dbf1e4be9b513ad4dbc (MD5) Previous issue date: 1957
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INVESTIGATION OF UNIQUE COENZYME A BIOSYNTHETIC AND REDOX FUNCTIONS IN Bacillus anthracis
Coenzyme A (CoASH) replaces the common tripeptide thiol glutathione as the major low molecular-weight thiol in the human pathogen Bacillus anthracis. A novel type III pantothenate kinase (PanK) catalyzes the first committed step in the CoASH biosynthetic pathway in B. anthracis. The 2.0 Å crystal …
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Regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase by reversible phosphorylation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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In Vitro Studies on Long Chain Acyl-Coenzyme-a Synthetase of Rat Liver
Made available in DSpace on 2015-05-12T22:36:30Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7511779.PDF: 6577574 bytes, checksum: a702f358ca4d3fd504cb7e94603f0f79 (MD5) Previous issue date: 1974
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Intermediates of coenzyme A biosynthesis in colon tissue: Normal vs inflammatory bowel disease
… in swine were associated with lowered levels of coenzyme A, the biologically active form of pantothenic acid. Colonic mucosal tissue removed from humans with chronic ulcerative colitis or Crohn's colitis has been shown to have significantly less coenzyme A activity than tissue removed from …
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Characteristics of the Recovery of the Coenzyme A-Synthesizing Protein Complex from Saccharomyces Cerevisiae
… which synthesizes CoA has been named the coenzyme A-synthesizing protein complex (CoA-SPC). The CoA-SPC has been shown to be insoluble in the crude Bakers' yeast cell lysate formed by exposing the yeast cell to ether and dry ice. Only after solubilization has this multienzyme complex been …
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The cloning and molecular regulation of rat 3-hydroxy-3-methylglutaryl coenzyme A reductase
We have cloned and sequenced the cDNA for rat HMG-CoA reductase the key regulatory enzyme in the mevalonate pathway. The amino acid sequence of rat HMG-CoA reductase is highly homologous to hamster and human reductases. Noncoding regions of the reductase mRNAs are also highly conserved. Rat HMG-CoA …
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Discovery and characterization of regulatory mechanisms affecting the heteromeric acetyl-coenzyme a carboxylase in Arabidopsis
Fatty acid biosynthesis (FAS) is an essential metabolic pathway used by all organisms to generate fatty acids. A staple component of this pathway is the enzyme acetyl-CoA carboxylase (ACCase), which catalyzes the committed step by converting acetyl-CoA to malonyl-CoA. The heteromeric form of this …
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Membrane Domain of Plant 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase: Targeting, Topology, and Function
The rate limiting step in isoprenoid biosynthesis is catalyzed by 3-hydroxy-3-methylglutaryl CoA reductase (HMGR, EC 1.1.1.34). In plants, HMGR is encoded by small gene families whose members are differentially expressed. In tomato, hmg2 was previously isolated and sequenced. We report the …
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Cloning and regulation of rat and Xenopus laevis hepatic 3-hydroxy-3-methylglutaryl Coenzyme A reductase
… and Xenopus laevis 3-hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) reductase have been cloned and sequenced. The rat liver HMG-CoA reductase cDNA clone contains one open reading frame coding for 887 amino acids. Its 106 nucleotide long 5$\sp\prime$-noncoding region contains no additional start …
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Molecular cloning, characterization, and expression of 3-hydroxy-3-methylglutaryl coenzyme a reductase gene from tomato
In plants, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR, EC 1.1.1.34) is a key enzyme regulating biosynthesis of phytosterols, plant growth regulators, carotenoids, antimicrobial defense compounds, and numerous other isoprenoids. To initiate molecular studies of HMGR in relation to defense …
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Expression of 3-hydroxy-3-methylglutaryl coenzyme a reductase in maize as influenced by light and bleaching herbicides
… of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, EC 1.1.1.34) is highly expressed in 4-day-old etiolated seedlings of normal ('DeKalb XL72AA'), dwarf (<u>d₅</u>), and albino (<u>lw₃</u>) maize (<u>Zea mays</u> L.). HMGR activity of maize seedlings appeared to be …
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The effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on oxidative and hypoxic stress in the vascular endothelium
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) improve endothelial cell (EC) function by enhancing the synthesis of Nitric Oxide (NO) and attenuating the endothelial leucocyte interaction and platelet aggregation. However the effects of statins on endothelial cell …
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Nuclear respiratory factor 1: a novel inhibitor of the human gene promoter of the cardiac isoform of acetyl-coenzyme a carboxylase
Introduction: Nuclear respiratory factor-1 (NRF-1) is a pivotal transcriptional modulator controlling the expression of nuclear genes encoding mitochondrial proteins. Activation of 5'-AMP-activated protein kinase (AMPK) has been associated with enhanced NRF-1 gene promoter binding activity. …
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Functional analyses of tomato 3-hydroxy-3-methylglutaryl coenzyme a reductase (HMGR) genes in transgenic plants engineered for altered HMGR expression
3-Hydroxy-3-methylglutaryl CoA reductase (HMGR, EC 1.1.1.34) mediates the first regulatory step (HMG-CoA reduction to mevalonate) in isoprenoid biosynthesis. The tomato genome contains at least four differentially regulated hmg isogenes encoding HMGR. Functions of tomato hmg2 in defense responses …
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The Effect of Different Dietary Lipids Upon Major Lipid Classes and Long-Chain Fatty Acyl Coenzyme-a Synthetase of Rat Liver Microsomes
Made available in DSpace on 2015-05-13T15:26:55Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7709117.PDF: 4695992 bytes, checksum: 2373c4fa8e38e6548835a1e90c3a2be8 (MD5) Previous issue date: 1976
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