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Showing 1 to 20 of 22 for “"Coeliac disease"”.
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Children, young people and coeliac disease
… literature about children and young people with Coeliac Disease, a common autoimmune disease characterised by an immune response to the protein gluten, found in wheat, barley and rye. It also comprises a qualitative research paper detailing interviews with young people that aimed to tap their …
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Studies on the pathogenesis of coeliac disease
… Inhibition (LMI) test with gluten in adult coeliac disease are shown to be affected by the histocompatibility antigen HLA-B8. Normal subjects with B8 show greater immunity than those lacking B8 and give similar results to untreated coeliacs. B8 and non-B8 coeliacs give similar results. A …
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Butyrophilin family genes as putative coeliac disease risk loci
Coeliac disease (CeD) is a T-cell mediated autoimmune enteropathy (1). CeD is triggered by the consumption of gluten, the collective name of a group of proteins present in wheat, rye, and barley (1, 2). The prevalence of CeD in the United Kingdom (UK) is around 1% and the number of new CeD …
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A Deep Learning Approach to Automated Coeliac Disease Diagnosis
Coeliac disease (CD) is a small intestinal autoimmune disorder triggered by the consumption of gluten. Manifestations are variable and non-specific, ranging from no symptoms, through fatigue, diarrhoea, and vomiting, and, in rare cases, lymphoma and duodenal cancer. The treatment consists of a …
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Gluten-free diet adherence in adult coeliac disease: Exploring multiple perspectives
Background: Coeliac disease is an autoimmune disease triggered by an inappropriate immune response to dietary gluten. This condition affects around 1% of the population and can lead to serious health complications, including nutrient deficiencies, infertility, osteoporosis and cancer. Symptoms, …
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Identification of Coeliac Disease Triggering Glutenin Peptides and Their Measurement in Foods
Coeliac disease is a common small intestinal disorder affecting approximately 1% of the Northern European population. It is caused by an inappropriate immune response to dietary gluten found in wheat, rye, barley and, for a small minority of patients, oats. There is mounting evidence to suggest …
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Forever gluten-free: exploring the psychosocial impact of living with coeliac disease
Coeliac Disease (CD) is an autoimmune disease in which the enzyme gluten causes inflammation and damage to the small intestine. Untreated the condition may predispose symptomatic individuals to serious diseases such as cancer, type I diabetes, osteoporosis, gynaecological problems in women, …
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The isolation and characterisation of Transglutaminase 2 inhibitors from natural sources
… enzymes which are involved in a variety of human disease conditions. Nine different isotypes of transglutaminases have been described including transglutaminase 2 (TG2) which is the most well characterised isotype. Transglutaminases possess a range of different catalytic activities including; the …
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Development of an efficient test for autoimmune disease using gold nanoparticles
Coeliac disease results because of an unusual immune response to the digestion of gliadin protein. Patients suffering from the disease show varying degrees of chronic inflammation within the small intestine ranging from mild lesions to completely flat mucosa. The immune response in turn, leads to …
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Personalised nutritional health assistant
… assistant, a chatbot, for individuals with Coeliac Disease is believed to be beneficial for individuals in pursuit of accurate data and those diagnosed with coeliac disease (CD). This condition is a chronic autoimmune disorder triggered by gluten consumption, a protein found in wheat, …
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Psychosocial factors associated with self-management and well-being in childhood chronic illness
… psychological well-being in young people with Coeliac Disease. Forty young people and 34 parents recruited from hospital outpatient clinics completed questionnaires. Results indicated timeline-cyclical beliefs and treatment concerns were associated with self-management. Timeline-cyclical, …
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A Genetic Analysis of the Relationship between Gluten Intolerance and Schizophrenia
relationship between schizophrenia and coeliac disease (CD) has long been postulated. However, despite the substantial genetic contribution defined for both conditions, the possibility of shared genetic risk factors has not previously been addressed. In this study, key CD-associated loci were …
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Transglutaminase and peptidylarginine deiminase in the pathogenesis of autoimmune diseases
Coeliac disease (CD) is becoming a model for understanding the pathogenesis of autoimmune disorders. In CD, antibodies against transglutaminase 2 (TG2) and specific glutamine residues of gliadins have been identified. A similar situation is seen in rheumatoid arthritis with both anticitrullinated …
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The role of chemokines in the pathology of multiple sclerosis and other neuroinflammatory diseases
… subacute sclerosing panencephalitis (SSPE) and coeliac disease (CD), with associated neurological complications, are neuroinflammatory diseases with different aetiologies, but which share common CNS neuropathological features including large perivascular inflammatory cell infiltrates, microglial …
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Nanocomposite immunosensor for anti-transglutaminase antibody
Coeliac disease (CD) is a gluten intolerance condition that results in the flattening of the villi, which line the bowel. It is the most common cause of malabsorption of food nutrients. This inability to absorb sufficient levels of nutrients causes many of the common symptoms experienced by CD …
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Metabolism of Biopterin and its Derivatives in Man and the Rat
… is raised before phenylalanine loading. In coeliac disease and malignant disease serum Crithidia factor is low. In carcinoid disease tissue levels of Crithidia factor are high although serum levels are low. Women in the third trimester of pregnancy have low serum Crithidia factor levels, …
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Metabolism and Handling of Folates in the Mammal Especially Man
… folates and folates in urine excretion. In some diseases even though total serum folates assayed with L.casei were in the normal range the three minor folates seemed to show abnormalities. In normal human volunteers there was rapid and almost complete metabolism in the serum to …
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Probing the distribution of gliadin proteins in dough and baked bread samples using conjugated quantum dots as a labeling tool
… Gliadin proteins are also able to activate coeliac disease which causes severe damages to the digestive system. Therefore, it is important to understand how gliadins are distributed in dough and the effect of baking conditions on distribution of gliadin in baked bread. QDs conjugated gliadin …
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The Surface Properties of the Mammalian Small Intestine: their role in the Absorption of Nutrients and their Variation in Health and Disease
… folate, and its variation in normal and diseased human intestinal conditions was investigated. The maximum acidity of the surface microclimate was measured in the proximal jejunum. The surface acid microclimate is created by the external hydrolysis of adenosine triphosphate (ATP) produced …
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Development of a toolbox for the reduction of hordeins in barley malt beers
… sensitive consumers and people suffering from coeliac disease account for up to 6% of the general population (Catassi et al., 2013). These consumers must avoid foods which contain gluten and related proteins found in wheat, rye or barley. Beer is produced from barley malt and therefore contains …
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