Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Codon bias"”.
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Information and the evolution of codon bias
… a case study of the genetic code (specifically, codon bias) and the translation system from the perspective of information. The codon biases of 831 Bacteria and Archeae are analyzed and modeled as points in a 64-dimensional statistical space. The major results are that (1) codon bias evolution …
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Evaluation of Altered Kras Codon Bias and NOS Inhibition During Lung Tumorigenesis
… <italic>RAS proto-oncogenes exhibit divergent codon usage. Of the three isoforms, <italic>KRAS contains the most rare codons resulting in lower levels of KRAS protein expression relative to <italic>HRAS and <italic>NRAS. To determine the consequences of rare codon bias during <italic>de …
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Genome Signatures Reveal the Importance of Context Dependent Codon Bias In A Range of Bacterial Genomes
… species was investigated for all four and six codon families to identify the role of context dependency on synonymous codon usage. Genome signatures of four nucleotide words were used to identify the distribution, magnitude and nucleotide contextual patterns.</p>
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Expression of single chain antibody-encoding genes in fission yeast and tobacco
… this strategy. It was established that murine codon bias did not preclude efficient expression of SCA genes in E. coli.
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Modulating Avidity of H8F4-Car By Regulation of Expression Via Codon Modification
… studies using the genetic code and its inherent codon bias. This was done by altering serine and arginine residues within the non-variable regions of h8F4-CAR from their endogenous codons into the rare codon isoforms TCG and CGT for serine and arginine, respectively. Synonymous codon modification …
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Vibrionaceae genome dynamics
… such as genome GC%, genome length, codon bias, plasmids, virulence and AMR genes are identified across the family in this research. From this a subset of genomes focused around *V. cholerae*, *V. vulnificus* and *V. parahaemolyticus* were selected for more in-depth study of gene …
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The Role of Codon Usage in Regulating Protein Expression, Structure and Function
Codon usage bias has been observed in the genomes of almost all organisms and is thought to result from selection for efficient translation of highly expressed genes. Many genes, however, exhibit little codon usage bias. It's not clear whether the lack of codon bias for a gene is due to lack of …
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Primary structure and expression studies of the dihydrofolate reductase gene (DFRI) of Saccharomyces cerevisiae
… termination and polyadenylation. Analysis of the codon usage of the yeast DFRl coding region revealed a codon bias index of 0.0083. this valve very close to zero suggestes 3 that the gene is expressed at a relatively low level under normal physiological conditions. The information concerning the …
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The Cellular and Molecular Dynamics of the Queuosine Modification in Transfer RNA: Definition, Modulation, Deficiencies and Effect of the Queuosine Modification System
… incorporated into tRNA<sup>asp</sup> anticodon stem/loop structures, and in triad complexes of tRNA<sup>asp</sup> with mRNA and tRNA<sup>phe</sup>. The results of this research identify indistinguishable energetic parameters for complexes of queuosine-modified anticodon loops when paired …
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A multiplexed approach for quantitative profiling of the translatome using bioorthogonal non-canonical amino acids
… genes. These genes also demonstrated a unique codon bias compared to the average codon usage of the genome. An analysis of codon frequency revealed changes in global codon usage over time following EGF stimulation. Changes in chemical modifications of tRNA isoacceptors were also observed which …
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How codon choice determines evolvability and evolutionary robustness in short linear motifs
… that is defined from the nucleotide and codon levels. Simulations using this methodology suggested that different codons have varying propensities to evolve into amino acids within a linear motif. In other words, some sequences have higher motif evolvability. The simulations also …
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Evolutionary analysis of Suidae TLR signaling pathway
… length, length of 3’ untranslated region and codon bias measured as Effective Number of Codons (ENC) were estimated for each gene sequence alignment. Gene position was significantly negatively correlated with evolutionary parameters ω (dn/ds) and dn suggesting that downstream genes in the …
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Comparative and Functional Analysis of Gene Expression in Ophiostoma Species
… EST datasets were also investigated to determine codon usage and to identify the presence of genes predicted to encode proteases. Both are important factors in recombinant protein expression. Protease production can severely inhibit the production of recombinant protein in fungal hosts. Based on …
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Developing novel systems for expression of intracellular membrane-bound human cytochrome P450 enzymes in baker’s yeast
… CYP genes chemically synthesized with yeast-biased codons. There are 61 codons which code for the 20 amino acids that are essential for protein syntheses. It is known that the highly expressed genes, in a particular organism, use specific codons which would indicate that there is codon bias. …