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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Codon Usage Bias"”.
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Codon Usage Biases Differ Between Tissues and Can Confer Tissue-Specific Gene Expression in Drosophila
<p>Codon usage bias is a fundamental aspect of the genetic code. For many years synonymous mutations to a coding sequence were considered to be functionally “silent.” We now appreciate that is not the case and that synonymous codon choice can have drastic implications for gene expression and …
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The Role of Codon Usage in Regulating Protein Expression, Structure and Function
Codon usage bias has been observed in the genomes of almost all organisms and is thought to result from selection for efficient translation of highly expressed genes. Many genes, however, exhibit little codon usage bias. It's not clear whether the lack of codon bias for a gene is due to lack of …
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The Roles of Codon Usage in Translational and Transcriptional Regulation on Gene Expression
Codon usage bias refers to the universal feature of genome that synonymous codons are used at different frequency. Codon usage plays critical roles in determining gene expression levels through impacting multiple fundamental cellular processes. Although the correlation between codon usage and gene …
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Attempt to express the Xerophyta viscose stress-responsive gene, Xvcor, in yeast with view to functional analysis
… of recombinant protein. A computer search for codon usage showed that the codon usage bias in Xvcor was low compared with that of highly expressed genes of S. cerevisiae. Together, these results suggest that the codon usage in Xvcor could influence its expression in yeast.
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Increased genome sampling reveals novel insights into vertebrate molecular evolution
… and polar bear. It is known that synonymous codon usage is governed by a combination of selective and neutral processes. Currently, it is thought that primarily neutral processes govern synonymous codon usage in vertebrates, possibly due to their lower long-term effective population sizes. …
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Improvements in codon usage analysis for a more detailed understanding of genome content and horizontal gene transfer
… amino acids to be encoded by multiple synonymous codons. Genes can vary in their utilization of synonymous codons, and this provides a basis of comparison for studying the compositional histories and evolution of genomes. The original goal of this dissertation work was to study the effects of …
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Collective Evolution of Biological and Physical Systems
… of the genetic code, and the emergence of genome biases. I present a new phase-field model of solidification which allows efficient computations in the regime when interface kinetic effects dominate over capillary effects. The asymptotic analysis required to relate the parameters in the …
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The Cellular and Molecular Dynamics of the Queuosine Modification in Transfer RNA: Definition, Modulation, Deficiencies and Effect of the Queuosine Modification System
… incorporated into tRNA<sup>asp</sup> anticodon stem/loop structures, and in triad complexes of tRNA<sup>asp</sup> with mRNA and tRNA<sup>phe</sup>. The results of this research identify indistinguishable energetic parameters for complexes of queuosine-modified anticodon loops when paired …
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Efforts to elucidate functional and regulatory aspects of gene expression in Trichomonas vaginalis
… data of this organism, I examined the roles of codon usage bias and RNA secondary structures in TE regulation of T. vaginalis mRNAs. I then designed a synthetic library of synonymous iLOV genes and expressed them in T. vaginalis. The fluorescence intensities produced by the in vivo expression of …