Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Cocultures"”.
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Studying Microglia-Mediated Neurodegeneration Using Cocultures
… automated analysis of images from primary cocultures. Early tests of these higher-throughput assays identified potential roles for urokinase (uPA) and spleen tyrosine kinase (SYK) in microglia-mediated neurodegeneration. uPA is an extracellular protease that may also regulate migration, …
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Effects of Three Corticosteroids on Equine Articular Cocultures In Vitro
The objective was to compare the effects of three corticosteroids at various equimolar concentrations on equine articular explant co-cultures in an inflammatory environment. Synovial and osteochondral explant co-cultures from 6 equine cadavers were exposed to IL-1β (10 ng/mL) and various …
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Cell-based strategies in bone tissue engineering. Effects of mesenchymal stem cell origin and cocultures with angiogenic cells
Contains fulltext : 118110.pdf (Publisher’s version ) (Open Access)
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Characterization of an Alternatively Spliced Platelet-Derived Growth Factor Variant During Myelin Synthesis
… dorsal root ganglion (DRG) neuron/Schwann cell cocultures and shown to regulate myelin synthesis. mRNA transcripts of the long-form PDGF-A chain variant (LF-PDGF-A) were detected by RT-PCR in cocultures. Its expression level increased during active myelin synthesis in contrast to those of the …
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Investigating the provision of vitamin B₁₂ in the Micro-Ecological Life Support System Alternative (MELiSSA) loop for long-distance space exploration using algal-bacterial cocultures.
… were observed. It was also possible to generate cocultures of *C. vulgaris* and *R. rubrum*, with *C. vulgaris* and *R. rubrum* designated as edible by various governmental authorities and the MELiSSA project, respectively. These cocultures were exposed to radiation to simulate time on the …
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MODELING PRO-INFLAMMATORY CROSSTALK BETWEEN MICROGLIA AND ASTROCYTES DURING HIV INFECTION
… observed increase in HIV replication in iMg/iAst cocultures. Indeed, we showed that addition of exogenous TNFɑ to iMg led to increased HIV replication, whereas neutralization of TNFɑ in iMg/iAst cocultures reduced HIV replication. Further, we used a pharmacological inhibitor of NF-κB signaling to …
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Enhancing energy recovery from industrial wastewater using microbial fuel cells
… Initial studies investigated the use of defined cocultures as a way of improving turnover of substrate and hence electricity produced by exploiting mutualistic relationships such as syntrophy or ability of facultative microoganisms (Saccharomyces cerevisiae) to consume residual oxygen from the …
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CROSSTALK BETWEEN GLIOMA CELLS AND TUMOR ASSOCIATED-MACROPHAGES: MECHANISMS AND THERAPEUTIC STRATEGIES
… or mutant IDH genes, through direct and indirect cocultures. Then we investigated the mechanisms underlying the macrophages-glioma cells’ crosstalk in hypoxia, a key aspect of the tumor microenvironment. In addition, in the context of nanovectors’ strategy, we set coculture models of macrophages …
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Steroid Hormone and Growth Factor Regulation of Peripheral Myelination
… the sciatic nerve of the null mice. Furthermore, cocultures established with DRG neurons and Schwann cells from the null mice showed decreased expression of myelin basic protein (MBP) transcripts. PDGF-A null Schwann cells differentiating into the myelinating phenotype without neurons expressed …
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Induction of hair follicles using neonatal mouse dermis and human keratinocytes: relevance for improved burn wound treatments
… marker analysis of human foreskin keratinocytes cocultures because of challenges and difficulties encountered during expansion. Therefore, Immortalised HaCaT keratinocytes were tested. HaCaT keratinocytes were shown to be induced during cocultures because they upregulated Wnt signalling genes, …
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Increased differentiation properties in two- and three-dimensional coculture of hepatocytes and liver epithelial cells by a novel quantitative functional liver assay
… of hepatocytes in 2D hepatocyte-LEC cocultures; we wished to determine if the benefit of coculture also occurs in the 3D microreactor.
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A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
… we investigated the following hypotheses: (1) cocultures of human umbilical cord blood-derived endothelial progenitor cells (hCB-EPCs) with mural cells can produce the microenvironmental cues necessary to support physiological microvessel formation in vitro; (2) poly(ethylene glycol) (PEG) …
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Adhesion and intercellular junction formation by pulmonary intravascular macrophages and endothelial cells in vitro
… their precursors to endothelium. A23187 added to cocultures enhanced adherence of intravascular macrophages to plastic, but not to endothelium. Pretreatment of either cell type with A23187 did not alter detectably adherence of intravascular macrophages to endothelial cells. Treatment of …
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Development of an endometrial inspired biomaterial
… tissue engineering techniques such as including cocultures of pro-angiogenic cells or the delivery of angiogenic factors within the biomaterials to direct cellular behavior. These methods have not shown the capacity to recreate the complexity of neovascular processes. The work described in this …
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Environmental Stress Can Favor Cooperation by Triggering an Adaptive Race Between Cooperators and Cheaters
… cooperators being less fit than cheaters, some cocultures rapidly purged cheaters, while in others cheaters dominated and drove cocultures and themselves extinct. Using deep sequencing and phenotypic analyses, I demonstrated the molecular mechanism responsible for this unanticipated outcome. …
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An oxygen-controlled in vitro model of the gastrointestinal human-microbiome interface
… oxygen in all parts of the system and to grow cocultures of human and bacteria cells. Epithelial cells grown in our bioreactor show signs of behaving more similarly to cells in vivo when exposed to the conditions present in our system, providing researchers with an oxygen-controlled …
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Systems analysis of cytokine mediated communication and signaling
… physiological cell populations than controlled cocultures. In this work, we also elucidated a number of positive and negative synergies in communication between monocytes and CD4+ T cells. A particularly interesting result was finding a synergy between INF[gamma] and TNF[alpha] for production of …
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Marine microbial co-cultivation and the production of novel bioactive secondary metabolites for drug discovery
… somaliensis) and SBT681 (Streptomyces sp.) cocultures were selected to scale-up the production of bioactive secondary metabolites for the treatment of metabolic diseases. Mass spectroscopy (MS) and 1D & 2D nuclear magnetic resonance (NMR) spectroscopy experiments in parallel with computer …
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Isolation of human amniotic stem cells from term placenta and their in vitro differentation in airway epithelium to correct CF phenotype
… usefulness in CF by in vitro experiments using cocultures of hAMSCs and CF-respiratory epithelial cells.
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Characterization of Vaccinia Virus-Induced Cytotoxic Cells in the Syrian Hamster
… cells generated in macrophage-bone marrow cocultures in vitro expressed high levels of the Thy 1.2 homologue as evidenced by their marked sensitivity to a (alpha)-Thy 1.2 + C'. We also demonstrated the presence of non-specific Thy 1.2 homologue-positive cytotoxic lymphocytes (T('+)CL) in …
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