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Showing 1 to 20 of 29 for “"Cocrystals"”.
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Structure of Cocrystals of Tropomyosin and Troponin
The contraction of vertebrate striated muscle is controlled by proteins found in the thin filament. Contraction is initiated when calcium binds to troponin, causing it and tropomyosin to undergo conformational changes. Tropomyosin is an $\alpha$-helical protein with two chains (284 residues each) …
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Investigating the Dissolution and Permeation Properties of Flufenamic Acid Cocrystals
… and permeation properties of flufenamic acid cocrystals in the presence of polymers. This study was separated into four tasks: (1) Formation of pharmaceutical cocrystals: Two pharmaceutical cocrystals of poorly water soluble active pharmaceutical ingredient (API) flufenamic acid (FFA) were …
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Effects of Polymers on Carbamazepine cocrystals phase transformation and release profiles
… the phase transformation and release profiles of cocrystals. Pharmaceutical cocrystals of Carbamazepine (CBZ) (namely 1:1 carbamazepine-nicotinamide (CBZ-NIC), 1:1 carbamazepine-saccharin (CBZ-SAC) and 1:1 carbamazepine-cinnamic acid (CBZ-CIN) cocrystals, were synthesized. A Quality by Design …
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Impurity-coformer cocrystals and/or complexes and their use in separations
… compound. In these cases we knew in advance that cocrystals of the impurity with particular coformers would form. The impurity content in the target crystals was approximately 20% less using the coformer than without the coformer. We then tested this method using the amoxicillin trihydrate without …
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A novel solvent-free high shear technology for the preparation of pharmaceutical cocrystals
… novel solvent-free method for the preparation of cocrystals. Cocrystals produced by HSMG were compared to those prepared by Hot Melt Extrusion (HME) to investigate the influence of variable parameters and conditions on the process of cocrystal conversion. The potential for the active control of …
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Crystal Engineering of Pharmaceuticals: Modulating Physicochemical Properties of Active Ingredients by the Formation of Cocrystals
… along with solubility and drug release of cocrystals is found to be superior to that of nifedipine. Lastly, crystal engineering principles utilised in preparation of multicomponent crystals of antidiabetic model drugs, glyburide and chlorpropamide with various coformers. Interestingly, …
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Development of cocrystals of water insoluble active substances with inactive excipients by using hot melt extrusion
… soluble drugs and their coformers. Two pairs of cocrystals of a poorly water soluble drug, carbamazepine, with saccharin and trans-cinnamic acid, were produced by using single (SSE) and twin screw (TSE) hot melt extrusion. The optimum barrel temperature for TSE was chosen from various temperature …
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Solvent Free Technologies for Polymer based Crystal Engineering and Drug Delivery
… of pharmaceutical amorphous system and cocrystals for poorly water soluble APIs. The S3M technology is getting first time reported for its application in pharmaceutical field and it is considered as technology with good potential for development of pharmaceutical dosage forms. The main …
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Evaluation of the Energetic Factors in Crystalline Pharmaceuticals Using Solid-state Density Functional Theory and Low-frequency Vibrational Spectroscopy
… can adopt including polymorphs, hydrates, and cocrystals. In this work, low-frequency vibrational spectroscopies and rigorous quantum mechanical simulations are combined to provide a new technique for characterizing and investigating pharmaceutically relevant polymorphs, hydrates, and …
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2,4,6-Tris(isopropylamino)-1,3,5-trinitrobenzene : Probing the Impact of Crystal Packing Forces in the Dimorphs and the Cocrystals–Experimental and Theoretical Study
We attempted to obtain a large amount of solvates of 2,4,6-tris(isopropylamino)-1,3,5-trinitrobezene 1 and tried to embark on a systematic study (both experimentally and theoretically) of conformational effects of crystal packing. Here we describe their investigation by X-ray diffraction, thermal …
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Cocrystallisation involving the thioamide, amide and imide functional groups
… on the development and characterisation of novel cocrystals that incorporated the thioamide, amide and imide functional groups. A particular emphasis was placed on the characterisation of these cocrystals by single crystal X-ray diffraction methods. In Chapter One a summary of the intermolecular …
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Understanding the crystal landscape of primary sulfinamides and predicting cocrystallization
… functional groups, to the synthesis of cocrystals. Chapter one is a brief introduction to the concepts and development of the field of crystal engineering over the past 30 years, including the definition and utilisation of the hydrogen bond in the synthesis of multicomponent materials, …
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Supramolecular modification of selected antitubercular drugs
… cyclodextrin (CD) inclusion complexes and cocrystals] and to isolate and characterise a range of solvated forms of the rifamycin antibioticsrifampicin and rifaximin.
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Implementing process analytical technology (PAT) tools for the analysis and control of manufacturing processes during hot-melt extrusion
… release formulations. Extruded pharmaceutical cocrystals were manufactured by using carbamazepine (CBZ) as a model drug with saccharine (SCH) and trans-cinnamic acid (TCA) as coformers at a 1:1 molar ratio. In-line NIR was employed to monitor the cocrystallization process along the HME barrel …
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Crystal Engineering of Flavonoids
… generate novel compounds such as pharmaceutical cocrystals. Flavonoids are polyphenolic secondary plant metabolites that are present in varying levels in fruits, vegetables and beverages. The "French paradox", low cardiovascular mortality rate in spite of high intake of saturated fat among the …
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Analytical method development for structural studies of pharmaceutical and related materials in solution and solid state. An investigation of the solid forms and mechanisms of formation of cocrystal systems using vibrational spectroscopic and X-ray diffraction techniques
… relevant materials. The existence of new cocrystals of salicylic acid-nicotinic acid, DLphenylalanine , 6-hydroxynicotinic acid, and 3,4-dihydroxybenzoic acid with oxalic acid have been identified from stoichiometric mixtures using combined techniques of Raman spectroscopy (dispersive and …
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Examination of stress-induced transformations within multicomponent pharmaceutical crystals
… of carbamazepine dihydrate and the specific cocrystals carbamazepine cocrystals formed with benzoquinone and oxalic acid. Chapter 5 is devoted to the dehydration of carbamazepine dihydrate for samples prepared and examined in approximate 1-gram laboratory scale quantities. It explores the …
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Crystallization of active pharmaceutical ingredients using microfluidic platforms and meniscus-guided coating
… solid form screening of polymorphs, salts, and cocrystals, however the solid forms obtained are often poor quality crystals that can only be characterized by vibrational spectroscopy (e.g,. infrared or Raman). In this work X-ray compatible microfluidic platforms were develop for on-chip …
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The supramolecular modification of trans-resveratrol and related antioxidant molecules
… constants 67 and 125 M⁻¹, respectively. Eight cocrystals were prepared with hydroxycinnamic acids and the GRAS compounds nicotinamide (NIC) and isonicotinamide (ISO) by coprecipitation, and were fully characterised. Single crystal X-ray diffraction confirmed the formation of cocrystals rather …
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Insight into Nucleation Kinetics of Flufenamic Acid Cocrystal Formulation in Solution: Investigating the Role of Polymeric Excipients through Combined Experimental and Computational Approaches
… soluplus (SOL), on the nucleation and growth of cocrystals of FFA with theophylline (FFA-TP) and nicotinamide (FFA-NIC) was evaluated. Cocrystals, as multicomponent crystalline solids, offer enhanced solubility and dissolution for poorly water-soluble drugs. However, their dissolution processes …
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