Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Cocaine-Related Disorders"”.
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The Role of Adult Neurogenesis in Cocaine Addiction
… drug-taking. I first examined effects of chronic cocaine self-administration and withdrawal on the different stages of neurogenesis. I found an early deficit in proliferation of neural progenitors, as well as a 4 week delayed increase in doublecortin-positive (DCX+) immature neurons which were …
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Examining the Relationship Between Impulsive Personalities and Neural Functioning in Cocaine-Addicted Participants
… included 24 healthy control participants and 56 cocaine-addicted participants. Participants ranged in age from 25 to 54 years old with a mean age of 43.27 (±SD 7.84). The group was comprised of 68 male and 12 female participants, 28.7% self identified as Caucasian, 66.3% African American, 3.8% …
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The Impact of Cognition on Treatment Adherence in Comorbid Bipolar Disorder and Cocaine Dependence
… were 120 outpatients with bipolar disorder and cocaine dependence enrolled in a 10 week randomized, double-blind, placebo controlled trial of lamotrigine. Baseline performance on the Stroop Color and Word Test and the Rey Auditory Verbal Learning Test were examined for their effect on retention, …
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Neural Dysfunction during Decision-Making as a Predictor of Cocaine Relapse
Cocaine dependence is a costly disorder characterized by recurrent relapse events. The current investigation used functional magnetic resonance imaging (fMRI) during a decision-making task to predict relapse to drug use in a cocaine-dependent sample. Forty-five treatment-seeking cocaine-dependent …
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Role of BDNF-TrkB Signaling in Cocaine Addiction
Cocaine addiction results in neuroadaptations and drug-induced neuroplasticity that promote changes in protein expression and neuron morphology. Cocaine-induced increases in dopamine ultimately alter dopamine signaling in brain regions modulating reward and motivation, specifically the nucleus …
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Novel Roles for the Activity-Regulated Genes Arc and Npas4 in Stress- and Cocaine-Induced Plasticity
Mood, anxiety, and substance abuse disorders are chronic medical illnesses that contribute significantly to morbidity and mortality worldwide. Currently, these conditions are treated symptomatically using pharmacological and psychotherapeutic approaches; however, the efficacy of these modalities is …