Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Cocaine Self-Administration"”.
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Parsing Distinct Aspects of the Addiction Process Using Cocaine Self-Administration, Behavioral Economics, Neuropharmacology and Neurochemistry
… understanding of the neurobiological basis of cocaine addiction, scientists have begun to investigate the neural adaptations occurring in association with changes in behavior observed in animal models of addiction. Exactly how these behavioral changes relate to the addiction process, however, …
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Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation
Maternal cocaine addiction is a significant public health problem yet
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Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration
… currently no FDA-approved drug treatments for cocaine abuse. The use of female subjects and a better understanding of the influence of hormones and cognitive function may provide valuable information to aid in pharmacotherapy development. The present studies utilized female monkeys housed in …
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Cocaine self-administration in rhesus monkeys: effects on neurobiology and cognition and evaluation of cognitive enhancement for addiction treatment
No effective drug treatments for cocaine dependence exist, although combined behavioral and pharmacological interventions, reviewed in Chapter I, may lead to better treatment outcomes. The goal of the current research is to characterize neurobiological and cognitive deficits associated with cocaine …
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Evaluation of agonist pharmacotherapy for cocaine dependence: effects of continuous d-amphetamine treatment on cocaine self-administration in rats
Cocaine dependence is a chronic disease which causes an immeasurable amount of detriment at both individual and societal levels. Although several promising pharmacological treatments are under development, the process of bringing an investigational drug to market requires substantial investments of …
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FACTORS THAT AFFECT SOCIAL HIERARCHY AND THE INFLUENCE OF SOCIAL RANK AND MENSTRUAL CYCLE ON COCAINE SELF-ADMINISTRATION IN FEMALE CYNOMOLGUS MONKEYS
… may have a greater biological vulnerability to cocaine addiction than males. Studying behavioral, neurochemical, neurobiological or physiological trait and state variables may provide some insight into individual difference leading to high risk for drug abuse. The research described in this …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
Cocaine use disorder is a chronic brain disorder characterized by high relapse rates and poor treatment outcomes; one variable known to engender relapse is exposure to environmental and discrete cues previously associated with drug-taking (cue reactivity). Human drug users experience an increase in …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
Cocaine use disorder is a chronic brain disorder characterized by high relapse rates and poor treatment outcomes; one variable known to engender relapse is exposure to environmental and discrete cues previously associated with drug-taking (cue reactivity). Human drug users experience an increase in …
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Understanding comorbid ADHD and cocaine abuse: consequences of adolescent medication in an animal model
… with substance use disorders, particularly cocaine. Preclinical studies using the well-validated Spontaneously Hypertensive Rat (SHR) model of ADHD suggest that adolescent treatment with the stimulant methylphenidate increases cocaine abuse risk in adulthood, highlighting the need to …
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Circadian Influences in Cocaine Reinforcement
… control that underlies (at least in part) self-administration behavior. This control can be over-ridden after extended self-administration and with higher dosing and access parameters. The neurobiological correlates of this control could prove to be a rewarding area of research in the …
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The Role of Adult Neurogenesis in Cocaine Addiction
… and amount of drug as well as the pattern of administration changes long-term effects on neurogenesis. In addition, it is unclear what role if any SGZ neurogenesis plays in initiating drug-taking or relapse behaviors, or whether changes in neurogenesis are merely side effects of drug-taking. I …
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Design, synthesis, and biological evaluation of sigma receptors (σRS) ligands as potential pharmacotherapy for cancer and drug addiction
… to be involved in acute and chronic effects of cocaine and methamphetamine toxicities. However, the role of sigma-2 receptors is less clear due to the lack of availability of detailed protein structural information and truly selective sigma-2 ligands, which hindered the pharmacological …
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A TALE OF TWO STRESS MODULATORS: EFFECT OF DELTA OPIOID RECEPTOR AGONISM AND FKBP5 INHIBITION ON GENE EXPRESSION AND BEHAVIOR DURING COCAINE WITHDRAWAL
… has become abstinent. Of all drugs of abuse, cocaine is most commonly involved in emergency department visits, and since 2013 there has been a rampant increase in overdose deaths involving cocaine. Symptoms of withdrawal from cocaine include anhedonia, sleep disturbances, intense cocaine …
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Transcriptomics of environmental enrichment and cocaine reveals roles for retinoic acid signaling and ΔFosB in addiction
… animals. Rats reared in the enriched condition self-administer less cocaine and display antidepressant-like behavior. To understand the molecular mechanisms of environmental enrichment, high-throughput next generation RNA sequencing technology was used to investigate the differential regulation …
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The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
… phosphorylation in vivo produced by chronic cocaine and heroin self-administration, changes in mesolimbic protein phosphorylation compared to individual differences in the propensity for escalating cocaine self-adminstration, and, ultimately, dopamine receptor-mediated regulation of relapse …
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UNIQUE PHARMACODYNAMIC PROFILE OF METHYLPHENIDATE: SELF-ADMINISTRATION-INDUCED DOPAMINE SYSTEM ALTERATIONS
… of action and equivalent potency at the DAT as cocaine. Although MPH is categorized as a DAT blocker, its pharmacological actions are distinct from both blockers and releasers in regards to both its acute effects and the compensatory alterations associated with self-administration of the …
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Effects of Cocaine Sensitization on Drug Self-Administration, Mesocorticolimbic SAPAP Levels, and Prefrontal Ionotropic Glutamate Receptors
… the male albino rat, and strived to explain how cocaine sensitization alters particular molecular mechanisms in the mesocorticolimbic system related to glutamate receptors, SAPAPs, and affects drug self-administration. Taking all the previously discussed research studies into consideration, we …
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The differential effects of stressors on aversive, novel and appetitive stimuli in rats
… studies examined the effect of restraint on drug self-administration. Restraint did not influence the acquisition or maintenance of cocaine self-administration, although restraint potentiated cocaine-induced locomotion. Restraint increased ethanol intake on the first post-restraint test only in …
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The Serotonin (5-HT) 5-HT2A Receptor is a Priority Target to Reduce Impulsive Action in Substance Use Disorders: Preclinical Evidence
… to forestall relapse vulnerability in cocaine use disorder (CUD). Pimavanserin suppressed impulsive action while baseline levels of impulsive action predicted the effectiveness of pimavanserin to suppress incubated cue reactivity in late abstinence from cocaine self-administration at …
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