Global ETD Search
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Showing 1 to 1 of 1 for “"Coats plus syndrome"”.
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On the Second Telomere Maintenance Machine: Structure, Recruitment, and Regulation of the CST–Polα/primase C-strand Fill-in Complex
… I also introduce the telomere biology disorder Coats plus syndrome (CP), which is caused by mutations in CST,and in one case, the shelterin subunit POT1.This thesis provides a molecular basis for the pathogenesis of a subset of these CP mutations.In Chapter 2,I set out to determine the structure …