Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Coacervation"”.
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Modeling coacervation in charged macromolecular systems
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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Theory of pattern and pH effects in complex coacervation
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
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The effect of physical molecular features on complex coacervation phase separation
Complex coacervation is an associative liquid-liquid phase separation of oppositely-charged polyelectrolytes in aqueous salt solution. This phase separation is sensitive to chemical and physical molecular features making it attractive for a large number of applications. However, precisely tuning …
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β-lactoglobulin and lactoferrin complex coacervates: Characterization and putative applications as encapsulation device
… to co-assemble into microspheres through complex coacervation. Understanding the driving forces governing heteroprotein coacervation process and how it is affected by the presence of ligands (bioactives) is a prerequisite to use heteroprotein coacervates as encapsulation device. In this context, …
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Coencapsulação de Lactiplantibacillus plantarum e compostos bioativos extraídos do jambolão (Syzygium cumini)
… and jambolan fruit extract (JE) by complex coacervation. Phenolic compounds were extracted from jambolan fruit using methanol, and the solvent was removed by rotary evaporation followed by freeze-drying. Microcapsules containing L. plantarum and 0% (ME-0%), 1% (ME-1%), or 5% (ME-5%) jambolan …
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Expression, Purification, And Characterization Of Elastin-Like Polypeptides Containing Chondroitin Sulphate Binding Domains
… to high purities. ELP1-CSBD1 was able to undergo coacervation in vitro, suggesting that ELP1-CSBD1 is able to self-assemble in a manner similar to native elastin. In the presence of the glycosaminoglycan chondroitin sulphate (CS), the temperature of coacervation of ELP1-CSBD1 is increased, the …
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Development of Polymeric Microparticle-Based Drug Delivery System for Sustained Delivery of H2S for Treatment of Glaucoma
… and GYY4137 were prepared using a non-aqueous coacervation method. Initial preparation attempts using coacervation solvent-evaporation resulted in overheating, uncontrolled solvent evaporation, polymer aggregation, and poor reproducibility. To overcome these limitations, a coacervation …
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Sonochemically-produced proteinaceous microspheres
… from reverse-phase evaporation into liposomes to coacervation into polymeric microspheres. Previously, Suslick and coworkers have used high-intensity ultrasound to generate nonaqueous-filled serum albumin microspheres. The mechanism involved the oxidation of cysteine residues by sonochemically …
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Engineering Mussel Foot Protein 5 (MFP5) for Enhanced Adhesive Performance in Tendon and Bone Repair
… recombinant techniques and optimized through coacervation and cross-linking. Adhesion tests demonstrated the superior performance of the optimized MFP5 adhesive on the tendon and bone samples. Improved protein concentration testing and purification methods enhanced MFP5 yield and consistency. …
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RNA-Peptide Based Coacervates as a Prebiotically Plausible Pathway towards a Proto-Ribosome
… chemistry environment, a new pathway emerges. Coacervation, a liquid-liquid phase separation event where two or more molecules undergo non-covalent interactions to form a secondary liquid phase, has been studied as a method of prebiotic compartmentalization. This thesis uses coacervates to …
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Discovering non-equilibrium mechanisms that regulatestructure and function of biomolecular condensates usingphase-field modeling
… with RNA transcription undergo complex coacervation with the RNA product. The first project in this thesis investigates the interplay between complex coacervation and spatially heterogeneous RNA synthesis on condensate morphology and dynamics using a phase-field model. This simple model …
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CHITOSAN PARTICLES FOR THE CONTROLLED RELEASE OF PROTEINS
… prepare chitosan nanoparticles 2) Emulsification-coacervation (NaOH) method to prepare chitosan microparticles 3) a polyelectrolytes coacervation method to prepare chitosan-BSA complexes 4) a microemulsion involved emulsification-coalescence method to prepare TPP-gelated chitosan microparticles 5) …
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Exploration of Hypotensive Effects of Novel Hydrogen Sulfide Donors: Mechanisms and Their Delivery
… release microparticle formulation using solvent coacervation to improve ocular delivery was developed, acknowledging the therapeutic need for sustained drug action. Through the optimization of parameters including silicone oil viscosity, surfactant type, and sonication settings, a reproducible …
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Method Optimization and Formulation of Chitosan Nanoparticle for PRPF31 Gene Delivery
… loaded with pDNA were prepared through a complex coacervation process. The NPs were characterized for particle size, poly dispersity index (PDI), zeta potential, and surface morphology. Additionally, the loading capacity, encapsulation efficiency, protective effect on the pDNA, in vitro …
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Tackling the Bottlenecks in Translational Nanomedicine: Towards Precision in Size Control and Facile Nanoformulation
… nanoformulation of drugs using the complex coacervation process. This method can be employed to bypass the special requirement of large-scale production and elongated shelf life of nanomaterials for various applications. Both systems illustrate great potential in clinical translation and can …
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Formation of Electrostatic Complexes within Admixtures of Lentil Protein Isolates and Anionic Polysaccharides (κ-Carrageenan, De-acyl Gellan Gum and Gum Arabic)
… The addition of sodium chloride (NaCl) disrupted coacervation, whereas the addition of urea caused a drop in the magnitude of the observed maximum optical density (O.D.). Increasing the temperature to 60°C resulted in a shift in turbidity curves towards more acidic pH and a decrease in maximum …
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Inducing Chirality in CdS Nanocrystals with Biomolecules
… QDs also exhibit thermally reversible coacervation, characterized by dynamic light scattering (DLS), small-angle X-ray scattering (SAXS), and transmission electron microscopy (TEM). Chapter 3 extends this glycine-mediated exchange strategy to CdS nanorods (NRs) and examines how Cys …
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In vitro and in vivo effects of sorghum condensed tannins encapsulated in kafirin microparticles on digestive amylases
… (KEMS) using aqueous ethanol and acetic acid coacervation methods. The inhibitory action of SCT on α- amylase and α-glucosidase were compared to acarbose (standard drug). The inhibition of SCT-KEMS after simulated gastrointestinal digestion was assessed. Electron microscopy was used to …
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Elastin-Like Peptide Dendrimers: Design, Synthesis, and Applications
… These results indicated the presence of a pre-coacervation step in the LCST phase transition of the ELP dendrimers. We further prepared hydrogels by crosslinking hyaluronic acid (HA) with ELP dendrimers. We invesigated their physical properties with scanning electron microscopy (SEM), swelling …
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