Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Coacervate"”.
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Characterization of Coacervate Systems Using Redox Sensitive Dyes
Coacervates are systems that spontaneously form when two oppositely charged polyelectrolytes are mixed in a concentrated salt solution. When coacervates form, a biphasic equilibrium occurs in the sample with two phases present in the solution. The two phases are described as the dense phase and the …
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Coacervate protocells as reaction centres at the origin of life
Contains fulltext : 325221.pdf (Publisher’s version ) (Closed access)
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Protein immobilization using complex coacervates and complex coacervate thin films
… can enhance the stability of enzymes. Complex coacervates are highly effective at encapsulating and stabilizing enzymes. This thesis demonstrates the use of complex coacervate thin films for the immobilization of enzymes and systematically probes methods to enhance the performance of these …
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Analyzing the interactions of thermoresponsive coacervate-forming biodegradable polyester encapsulation on model protein structure and activity
… of protein therapeutics. Thermoresponsive coacervate-forming biodegradable polyesters (TR-PEs) are a thermoresponsive molecular packaging system used in protein therapeutic research. The term coacervate refers to a phase-separated solution in which a dense polymer phase separates from the …
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RNA-Peptide Based Coacervates as a Prebiotically Plausible Pathway towards a Proto-Ribosome
… prebiotic compartmentalization. This thesis uses coacervates to mimic the peptide forming reaction that occurs within the peptidyl transferase centre of the ribosome. To begin with an appropriate coacervate environment was found through the study of prebiotically a plausible peptide FRGRGRGA …
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The effect of physical molecular features on complex coacervation phase separation
… amount of theoretical modeling of complex coacervates has been performed using a number of approaches such as Voorn-Overbeek theory, polymer field theory, counterion condensation and release, and liquid state theories. While these theories have given physical insights into coacervation, …
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Tackling the Bottlenecks in Translational Nanomedicine: Towards Precision in Size Control and Facile Nanoformulation
… delivery system using a polyelectrolyte coacervate system was created to achieve the facile fabrication of nanomedicine. Nanosized coacervates were successfully formulated with a pair of polyelectrolytes and a chemotherapeutic drug. With the intracellular trafficking properties provided …
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Self-assembly of cross-linked polymer micelles into complex higher-order aggregates
… Similar structures can be prepared using complex coacervate core micelles (C3Ms) built through the interaction of weakly acidic and basic polymer blocks. The advantage of these structures is that two different stabilizing blocks can be incorporated, which allows for more diverse and complex …
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β-lactoglobulin and lactoferrin complex coacervates: Characterization and putative applications as encapsulation device
… is a prerequisite to use heteroprotein coacervates as encapsulation device. In this context, the objective of my thesis work was to understand the mechanism of complex coacervation between β-lactoglobulin (β-LG) and lactoferrin (LF) in the absence and presence of small ligands. The …
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Development of Polymeric Microparticle-Based Drug Delivery System for Sustained Delivery of H2S for Treatment of Glaucoma
… successfully developed. The stability window for coacervate formation in the PCL–dichloromethane–silicone oil system was determined using ternary phase behavior studies, and formulation parameters including silicone oil concentration, surfactant type, and surfactant concentration were optimized. …
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Increasing Sustainability of the Papermaking Process via Formulation of Cellulose Nanofibers and Polyelectrolyte Complexes
… of solid-like precipitate or liquid-like coacervate forming polyelectrolyte complexes (PECs) enhances the interactions of the PECs to cellulose fibers and how this improves water retention and increases percent solids. This work specifically studies the effects of mixing order and the …
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Single-Molecule Investigation of Chromatin-Associated Factors in Genome Organization and Epigenetic Maintenance
… potential role for linker histones to sense and coacervate single-stranded nucleic acids in the nucleus, forming reaction hubs for genome maintenance. This work also provides a new perspective to understand how various H1 subtypes and disease-associated mutations affect chromatin structure and …
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Control of surface structure and properties of responsive hydrogel interfaces via electrostatic interactions
… of responsive charged interfaces composed of coacervates These three tasks were accomplished by combining imaging methods by Atomic Force Microscopy with surface-sensitive spectroscopic (infrared spectroscopy) and rheological measurements to provide insight into the …