Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"CoREST"”.
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P120-Catenin Regulates Rest and Corest, and Modulates Mouse Embryonic Stem Cell Differentiation
… binds to and negatively regulates REST and CoREST, that others have indicated form a repressive complex having diverse key roles in developmental and pathologic gene regulation. We thus provide the first evidence for a direct upstream modulator of REST/CoREST function. Using mouse embryonic …
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Efforts to Elucidate the Binding Interaction between Lysine-Specific Demethylase 1 (LSD1/KDM1) and CoREST and Their Roles in Breast Cancer
… with a number of co-regulatory proteins. CoREST is one such important binding protein that endows LSD1 with the ability to associate with and demethylate nucleosomal substrates. </p><p>Given the significance of CoREST in directing LSD1 activity, herein we report our efforts to regulate …
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Analysis and suppression of mutant sel-12 in Caenorhabditis elegans
… is found to be an integral component of the CoREST transcriptional co-repressor complex. Further analysis of the other spr genes revealed that SPR-1 is the C. elegans homolog of the human CoREST protein, which is also a component of the CoREST complex. Based on the physical interaction of …
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Characterisation of oncogenic pathways driving the pathogenesis of prostate cancer
… demonstrated that TBX2 interacts with CoREST complex members LSD1 and ZNF217 and ChIP qPCR confirmed TBX2 shRNA reduced ZNF217 recruitment to E-cadherin and NDRG1 promoters. In accordance, targeting the LSD1/ZNF217 interaction via an allosteric LSD1 inhibitor phenocopied TBX2 knockdown …
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Simulating biochemical physics with computers
… demethylase (LSD1) in complex with CoREST and protein-substrate interactions of LSD1 with histone H3 tail. MD simulations of LSD1•CoREST complex bound to a 16 a.a. of the Nterminal H3-tail peptide (H3-p16) were carried out using NAMD to study the conformational flexibility of the …
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Lysine Specific Demethylase-1 and the Brahma Chromatin Remodeling Complex Regulate Conserved Signaling Pathways During Drosophila Wing Development
… loss of Co-RE1 Silencing Transcription Factor (CoREST), an accessory protein required for LSD1 demethylase activity, results in a similar wing patterning phenotypes, suggesting that demethylase activity is required for proper cell-fate specification. By utilizing a variety of biochemical and …
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Studies of the MYM-type zinc finger protein ZMYM3
… deacetylase, LSD1, a histone demethylase, CoREST, a co-repressor of transcription, TFII-I, a transcription factor, and ZMYM3, an MYM-type zinc finger protein of unknown function. By making several truncation mutants of ZMYM3, I show that a C-terminal region containing a ‘PXP’ repeat motif …
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Functional characterization of CDY family proteins and their role in recognition of the heterochromatic histone H3K9me3 modification
… (HDAC1, HDAC2) oder dem Repressorkomplex CoREST erreicht wird. Interessanterweise konnte in der vorliegenden Doktorarbeit ein weiterer Interaktionspartner von CDYL1 identifiziert werden: PRMT5. PRMT5 ist eine Argininmethyltransferase und in vitro Experimente bestätigen, dass PRMT5 CDYL1 …