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Showing 1 to 20 of 414 for “"CoA"”.
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CoA-transferase and 3-hydroxybutyryl-CoA dehydrogenase: acetoacetyl-CoA-reacting enzymes from Clostridium beijerinckii NRRL B593
… the metabolic intermediate acetoacetyl-CoA can be directed toward butyrate or butanol formation by the reaction catalyzed by 3-hydroxybutyryl-CoA dehydrogenase, or toward acetone formation by the reaction catalyzed by acetoacetate:acetate/butyrate CoA-transferase. 3-Hydroxybutyryl-CoA …
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Phosphorylation of Skeletal Muscle Acetyl-CoA Carboxylase by AMPK Enhances Palmitoyl-CoA Inhibition
Acetyl-CoA carboxylase (ACC) catalyzes the formation of malnoyl-CoA, which in turn controls the rate of fatty acid metabolism. ACC beta or 2 has been shown to be localized on the mitochondria in close proximity to carnintine palmitoyl transferase 1 (CPT-1), the enzyme responsible for the influx of …
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3-Methylcrotonyl-CoA: Carboxylase Mangel
Der isolierte 3-Methylcrotonyl-CoA: Carboxylase (MCC) Mangel ist eine angeborene Störung im Abbau der Aminosäure Leucin. Es sind sowohl bis ins Erwachsenenalter asymptomatische als auch frühe letale Verläufe beschrieben. Die Ursachen des variablen Phänotyps sind nicht verstanden. Das Enzym ist …
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Studies of Escherichia coli Acetyl-CoA carboxylase
Acetyl-CoA carboxylase (ACC) initiates the first committed step of fatty acid synthesis. ACC is composed of three separate components: biotin carboxylase (BC), carboxyltransferase (CT), and biotin carboxyl carrier protein (BCCP). BC carries out the first half of the ACC reaction where it catalyzes …
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Acetyl-CoA metabolism and human trophoblast differentiation
… to histone acetylation by producing acetyl-CoA, a substrate for epigenetic modifications. The hypothesis was that ACLY is essential for maintaining trophoblast stemness by providing a localised supply of acetyl-CoA for histone acetylation, thus leading to a transcriptionally permissive state …
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Studies on Methylmalonyl-CoA Mutase from Escherichia coli
Methylmalonyl-CoA mutase (MCM, E.C. 5.4.99.2), a coenzyme B12-dependent enzyme, catalyses the inter conversion of succinyl-CoA and methylmalonyl-CoA. The gene (sbm) encoding this enzyme is found in Escherichia coli (E. coli) at 62.3min on the E. coli chromosome. However, the metabolic role of this …
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Studies of Acetyl-Coa Carboxylase From Escherichia Coli
Preliminary functional assignments for the two subunits in the carboxyltransferase complex have been given. The alpha subunit (AccA) appears to have a structural role in the total ACC complex while the beta subunit (AccD) could contain the carboxyltransferase active site. The above conclusions are …
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Ubiquitin E3 ligase mediated regulation of HMG-CoA Reductase
… class I molecules. The ER-resident enzyme HMG-CoA reductase (HMGCR) catalyses the rate-limiting step in the cholesterol biosynthesis pathway and is targeted therapeutically by statins. To maintain cholesterol homeostasis, the expression of HMGCR is tightly regulated by sterols transcriptionally …
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A Specialized Citric Acid Cycle Requiring Succinyl-Coenzyme A (CoA):Acetate CoA-Transferase (AarC) Confers Acetic Acid Resistance on the Acidophile Acetobacter aceti
… acid cycle: CAC) that lacks succinyl-coenzyme A: CoA) synthetase. The acetic-acid-resistance protein succinyl-CoA:acetate CoA-transferase: SCACT, AarC) circumvents this deficiency and bypasses substrate-level phosphorylation and/or adenylation of acetate. Continuous acetate dissimilation by this …
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Strukturelle Untersuchungen an dem Radikalenzym (R)-2-Hydroxyisocaproyl-CoA-Dehydratase
… katalysiert. Die (R)-2-Hydroxyisocaproyl-CoA-Dehydratase katalysiert die Dehydratisierung von (R)-2-Hydroxyisocaproyl-CoA in der Fermentation von L-Leucin im humanpathogenen Bakterium Clostridium difficile. Im Gegensatz zu einer Vielzahl von Radikalenzymen, wie beispielsweise der Coenzym …
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Studies on the mechanism of action of propionyl-CoA carboxylase
Propionyl-CoA carboxylase has been purified to a state of near nomogeniety, and some of its enzymatic properties relating to substrate binding and mechanism of action have been studied. The enzyme was not found to catalyze the incorporation of solvent tritium at the c-carbon of propionylâ CoA in …
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ACETYL COA CARBOXYLASE 1 IN PROSTATE CANCER AS A CHEMOTHERAPEUTIC TARGET
… dissertation describes the requirement of acetyl-CoA carboxylase 1 (ACC1), the rate-limiting step of de novo fatty acid synthesis, for the development and progression of prostate cancer. Prostate specific deletion of ACC1 activity reduced tumor burden in 12-week-old C57BL/6J mice. However, …
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Reinigung und Charakterisierung der alpha-Methylacyl-CoA-Racemase aus menschlicher Leber
… Fettsäuren spielt die alpha-Methylacyl-CoA-Racemase eine wichtige Rolle, indem sie die (R)- und (S)-Isomere von alpha-methylverzweigten Fettsäuren als Coenzym A Thioester racemisiert. Methylverzweigte Fettsäuren entstehen beim Abbau von Isoprenoiden und werden darüber hinaus auch von …
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Metabolic control of the ethylmalonyl-CoA pathway in Methylobacterium extorquens AM1
… M. extorquens AM1 utilizes the ethylmalonyl-CoA pathway that involves several rare four- and five carbon CoA-esters of great biotechnological interest. M. extorquens AM1 also incorporates carbon dioxide as half of the fixed carbon during biomass production, making it a desirable organism to …
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Studies on the pyruvate dehydrogenase phosphatase and 3-hydroxyisobutyryl-CoA hydrolase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Molecular cloning and characterization of 3-methylcrotonyl-CoA carboxylase from soybean
… biotin-containing subunit of 3-methylcrotonyl-CoA carboxylase (MCCase). This is the first plant gene coding for a biotin-containing enzyme to be cloned. It is also the first time that the primary sequence of the biotin-containing subunit of MCCase has been determined;The deduced amino acid …
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Understanding the Mechanism of Succinyl-CoA Synthetase Catalysis from Structural Studies
The catalytic mechanism of succinyl-CoA synthetase (SCS) was investigated using X-ray crystallography. Two nucleotide-specific forms of SCS exist in mammals, of which one is ATP-specific (ATPSCS) and the other is GTP-specific (GTPSCS). ATPSCS and GTPSCS share the same α-subunit, but have a …
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Characterization and analysis of genes encoding Escherichia coli acetyl-CoA carboxylase
Acetyl-CoA carboxylase catalyzes the first committed step of fatty acid biosynthesis, the synthesis of malonyl-CoA. In Escherichia coli the enzyme is a complex of four subunits that catalyzes two distinct half-reactions.
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Characterization and Heterologous Expression of Recombinant Drosophila melanogaster Fatty Acyl CoA Reductase
Insect genomes have multiple fatty acyl CoA reductases (FARs), which implies varying substrate and product profiles. However, very few of these FARs have been characterized. Expression of the FAR CG18031 from Drosophila melanogaster in Spodoptera frugiperda (Sf)9 cells will allow for functional …
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