Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"Co-treatment"”.
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Synergic Effect on Cell Death by Co-treatment with TRAIL and Human Anti-DR5 Antibody
… variable fragment (scFv) antibody (HW1) that recognizes a different epitope on DR5 form that of TRAIL and induced autophagic cell death. when treated to various cancer cell lines. To study the interaction between TRAIL-induced apoptosis and HW1-induced autophagic cell death delivered from DR5 …
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A prototype dynamic model for the co-treatment of a high strength simple-organic industrial effluent and coal-mine drainage
… sulfate reduction technologies for the treatment of Sasol Secunda's coal-mine drainage (CMD) using Fischer-Tropsch Reaction Water (FTRW) as a cost-efficient carbon source. The research aims to develop a prototype dynamic model that describes this co-treatment of FTRW and CMD in both a …
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Strategies for optimising TB-HIV co-treatment in children and adolescents with drug-susceptible tuberculosis on rifampicin-based standard regimens
… to tuberculosis (TB) and often require concurrent antiretroviral treatment (ART) and antituberculosis therapy. However, rifamycins, the key drugs for TB treatment, significantly interact with many ART classes, necessitating adjustments to one or both therapies. In African and other …
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Investigation of the Effects of Genistein and Fenretinide on Ovarian Cancer Cells
… of the fenretinide and genistein as single or combined drugs on ovarian cancer proliferation and viability were investigated. Hypothesis: Co-treatment with genistein will enable a lower dose of fenretinide to be effective in inhibiting the proliferation and survival of ovarian cancer cells. …
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An investigation into the novel effects of melatonin treatment on differentiated C2C12 myotubes in the absence and presence of pathology
… it has been proposed as an alternative means of treatment for oxidative stress, mitochondrial dysfunction and injury-related damage to skeletal muscle. However, despite its promising therapeutic potential, much remains unknown with regard to its impact on healthy or pathologically challenged …
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Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation
… virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral neuropathy (INH-PN). In co-infection with and co-treatment for HIV/TB, DSP …
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Mitotic slippage by ATP depletion and its mechanism
… progression. In our hand, ATP depletion by the co-treatment with 2-deoxy glucose (2-DG) and sodium azide (NaN3) during interphase caused robust cell cycle arrest, supporting the existence of energy checkpoints sensing shortage of ATP supply before mitosis. On the other hand, reduction of ATP …
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The effect of Aspalathin on Doxorubicin-induced Cardiotoxicity
… first-line chemotherapeutic agent used in the treatment of a broad range of solid and hematological tumors. Though effective, the use of Doxorubicin in cancer therapy has been hindered by its cardio toxic side effects. As yet, no single chemical synthesized drug or compound is known to prevent …
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Interrelationships among estrogen, insulin-like growth factor-I and cyclic adenosine monophosphate in the regulation of uterine progesterone and estrogen receptors
… increases in progesterone receptor (PR) content. Stimulation of PR levels by these agents was suppressed equally by co-treatment with antiestrogen (ICI 164,384) or protein kinase inhibitors, or by pre-treatment of cells with actinomycin D or cycloheximide. These results suggest that …
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The molecular pathways mediating the role of cyclooxygenase enzymes and prostaglandins in cervical neoplasias
… of the EP4 receptor within the epithelial compartment suggested that prostaglandin E2 may act in an autocrine/paracrine manner to modulate epithelial cell function and promote tumourigenesis. In addition to endogenous prostaglandin E2, EP receptors in cervical carcinomas can be activated by …
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Transient Metabolic Alterations Induced by Chemotherapeutics in Cancer Persisters
… slow-cycling persister cells that survive drug treatments and give rise to multi-drug tolerant mutants in cancer. The mechanisms associated with persister phenotypes are highly diverse and complex, and many aspects of persister cell physiology remain to be explored. In this study, we aim to …
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Nuclear receptor co-repressor actions in bladder cancer
… with relative mRNA expression of a range NRs and co-repressors in four bladder cancer cell lines. Nuclear co-repressor 1 (NCoR1) is over-expressed in RT-112 (1.6 fold) and EJ-28 cells (2.6 fold). This correlates with reduced sensitivity to NR ligands in EJ-28 cells. Stable over-expression of NCoR1 …
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Induction of Stronger and Long Lasting Vaccine Immunity to Tuberculosis
… elements via p38 and ERK1/2 MAP kinases. I conclude from Aim-I studies that TLR-7/9 ligands can be used as more effective ‘adjuvants’ for BCG vaccine.</p> <p>In Aim-II, I evaluated the poor CD8 T cell function in BCG vaccinated mice thought to be due to a decreased leak of antigens into …
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DNA FRAGILE SITE BREAKAGE AS A MEASURE OF CHEMICAL EXPOSURE AND PREDICTOR OF THE SUSCEPTIBILITY TO FORM CHROMOSOMAL REARRANGEMENTS
… particularly susceptible to breakage termed “common fragile sites (CFS)”. To test the hypothesis that fragile site breakage underlies the formation of chromosomal rearrangements, we focused on RET/PTC rearrangements in papillary thyroid carcinoma. All genes participating in the two most common …
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Retinoic Acid Regulation of Thyroid Hormone Action in Bone Cells
… formation. We demonstrate that thyroid hormone treatment stimulates differentiation of ATDC5 chondrocytes and promotes formation of mineralized nodules while retinoic acid treatment at high dose inhibits chondrocyte differentiation and formation of mineralized nodules. Furthermore, thyroid …
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Induction of death in myeloid leukaemia cells by doxorubicin and betulinic acid, singly and in combination was associated with the regulation of apoptosis, autophagy and the PI3K/Akt pathways
… autophagy and other cell processes, may contribute to this trend. Using chemical agents could modulate these signalling pathways. Drugs such as doxorubicin (Dox) are effective but displayed some clinical drawbacks, while compounds such as betulinic acid (BetA) have shown some interesting …
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ACETYL COA CARBOXYLASE 1 IN PROSTATE CANCER AS A CHEMOTHERAPEUTIC TARGET
… dissertation describes the requirement of acetyl-CoA carboxylase 1 (ACC1), the rate-limiting step of de novo fatty acid synthesis, for the development and progression of prostate cancer. Prostate specific deletion of ACC1 activity reduced tumor burden in 12-week-old C57BL/6J mice. However, …
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Sunitinib-Induced Cardiotoxicity Exposes Microvascular and Metabolic Derangements In The Failing Heart
… one of the largest obstacles to effective cancer treatment. Not only do a growing number of cancer patients have significant cardiovascular risk factors at the time of diagnosis, but a number of targeted therapies can themselves cause cardiac dysfunction. These newer treatment options are also …
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Therapeutic Potential of Prmt5 and Mat2A As Synthetic Lethal Targets In Mtap-Deficient Gbm Tumors
… human GBM tumors are not significantly higher compared to <em>MTAP</em>-intact tumors. This discrepancy is due to the secretion of MTA into the extracellular environment and its subsequent metabolism by stromal cells expressing MTAP. We also have demonstrated that the presence of …
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Exploring combined effects of arsenic and selenium exposure on larval zebrafish (Danio rerio)
Arsenic contamination in aquatic ecosystems is a major environmental concern, with arsenite (As³⁺) being highly toxic. Selenium (Se) helps mitigate oxidative stress and hence could reduce the toxic effects of arsenic. However, Se can also be toxic at high concentrations. Given that these metalloids …
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