Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"Co-solvents"”.
-
Interações da trancinolona com ciclodextrinas em sistemas multicomponentes
Triamcinolone is a relevant anti-inflammatory costicosteroid drug, used mainly by injectable suspensions due its poor water solubility. The association of triamcinolone with cyclodextrins and co-solvents (triethanolamine TEA and N-methylpirrolidone NMP) was held to solubilize the drug and explain …
-
Investigating the Interaction of Chitin in Organic Electrolyte Solutions Using Molecular Dynamics
… to disrupt and dispersion forces to overcome, all of which make it insoluble in most common organic solvents and water under moderate conditions. Much work has been devoted to improving the dissolution of biopolymers, via alternative solvents or by developing new ground-breaking …
-
G-Quadruplexes As Molecular Targets For Transcriptional Control
… (G4s) have gained interest in modern drug discovery efforts. The majority of G4 research, including the mass of this research, heavily focuses on cancer therapeutic development, as G4s are more pronounced in oncogenic promoters compared to the rest of the genome, our efforts extend towards …
-
Biofuels from Liquefaction of Marine Microalgae: Production, Upgrading, and Environmental Impacts
… production as it grows rapidly even in adverse conditions, and fixes carbon dioxide from the atmosphere by photosynthesis. Hydrothermal liquefaction (HTL) of microalgae is a promising conversion technology in which algal biomass is treated as an aqueous slurry under high temperature and …
-
Directed evolution of Arabidopsis thaliana carotenoid cleavage dioxygenase 1
… and 9’-10’ position. The active site of CCDs contains a central, heme-free Fe2+, which is coordinated by four histidines. The enzymatic oxidation utilizes molecular oxygen and does not require further cofactors. This unique cleavage step is used in nature to create a huge variety of colorants, …
-
Surfactants and enhanced oil recovery
A large number of commercial and some novel Brunel synthesised surfactants have been studied with a view to their potential usefulness for enhanced oil recovery (EOR) application. Ethoxylated phenols and their sulphonated derivatives were given especially high priority. The surfactants were …
-
Spectroscopic studies of hydrophobic association of merocyanine dyes in cationic and anionic micelles
… diluted with various proportions of the organic co-solvents such as pyridine. The color varies across the whole spectrum from golden yellow to blue.These characteristic properties of merocyanine dyes in various organic solvents have been extensively studied and correlations between [see PDF file …
-
Improved Properties of Natamycin Upon Formation of Cyclodextrin Inclusion Complexes
Natamycin is an antimycotic with very low water solubility and extremely high photosensitivity, which is used to extend the shelf life of shredded cheese products. The objectives of this research are: (a) to find a new delivery system for natamycin, which increases its aqueous solubility and (b) to …
-
Catalytic implications of confined solvent ensembles within Lewis acid zeolites
… promise as catalysts for the activation and conversion of biomass-derived precursors in the liquid-phase due to their unique water-tolerance and synthetic versatility. The active site environment in zeolite catalysts is multifaceted in nature and is composed of a primary catalytic binding …
-
Controlling the interfacial behaviour of colloidal microgel systems
Hydrophobically modified colloidal microgel particles were prepared by a surfactant-free emulsion polymerization of N-isopropylacrylamide (NIPAM) with more hydrophobic vinyl ether/ester/silane co-monomers (10 % total mass monomer). Most of the resultant dispersions were novel co-polymer microgels …
-
Formation of Cyclodextrin-Drug Inclusion Compounds and Polymeric Drug Delivery Systems using Supercritical Carbon Dioxide
… engineering and drug delivery. Scaffolds with controlled pore morphologies have been generated which incorporate cyclodextrin-drug inclusion complexes as the drug delivery component. Supercritical CO2 was explored as the main processing fluid in the complex formation and in the foaming of the …
-
Ionic Liquids in the Chemical Valorisation of Pulps and in their Chemical Analyses
… sulfoxide (DMSO) or gamma valerolactone (GVL) as co-solvents. All of the ILs utilised in this work were synthesised in our laboratory via Menshutkin reaction followed by metathesis to different counter anions or via acid-base chemistry. The beginning of our work focused on the investigation of the …
-
Investigation of Enhancement of Furosemide Solubilization with Cyclodextrins and a Novel Octenyl Succinate Anhydride Starch
… is one of the most challenging aspects for drug commercialization and often the main reason of drug that do not reach to its full potential. Now nearly 60% new chemical entities possess solubility problems, whereas practically no drug products with less than 10 µg/ml solubility in 70’s or 80’s. …
-
Self-assembly and selective swelling in Lamellar block copolymer photonic gels
Materials with responsive structural color have broad applications ranging from sensing to smart coating. Nature provides inspirations for the design of such materials. Mimicking the structure of the skin elements responsible for cephalopod's fast camouflage, we made photonic gels using lamellar …
-
P3HT:PCBM-based organic solar cells : Optimisation of active layer nanostructure and interface properties.
… on a flexible substrate as well as scope for large-scale production using role to role technique. Improving the performance of the organic solar cells and their lifetime stability are one of the main challenges faced by researchers in this field. In this thesis, work has been carried …
-
Siloxane-Based Reinforcement of Polysiloxanes: from Supramolecular Interactions to Nanoparticles
… unique class of synthetic polymers, employing a completely inorganic backbone structure comprised of repeating –(Si–O)n– 'siloxane' main chain linkages. This results in an assortment of diverse properties exclusive to the siloxane bond that clearly distinguish them from the –(C–C)n– backbone of …
-
Capturing Complex Microenvironments for Directed Stem Cell Differentiation
… synthetic or autologous vascular grafts. To overcome the limitations associated with adult cell sources, which are often restricted by supply or compromised by disease, mesenchymal stem cells (MSCs) have emerged as potential candidates for vascular tissue engineering. While evidence suggests the …
-
NMR/MRI SIGNAL ENHANCEMENT BY REVERSIBLE EXCHANGE (SABRE) AND HETEROGENEOUS SABRE (HET-SABRE)
… Polarization) pioneered by Duckett, Green, and co-workers where an organometallic catalyst is used to co-locate parahydrogen (pH2) and a molecular substrate to be hyperpolarized. Like traditional PHIP, SABRE is of interest because it is cost-effective, potentially continuous, scalable, and rapid …
-
Structure and Reactivity in Nanostructured Ionic Solvents
Deep eutectic solvents (DESs) are low melting mixtures, often prepared from a hydrogen bond acceptor (HBA) salt and a molecular hydrogen bond donor (HBD) at a specific molar ratio. These unique solvents are of increasing research interest due to their potential for simple, 100% atom economical …