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Showing 1 to 3 of 3 for “"Co-milling"”.
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Exploring co-milling as a strategy to improve the dissolution of poorly water-soluble drugs
… absorption of many poorly water-soluble drugs. Co-milling offers a solvent-free and industrially scalable technology to overcome dissolution rate limited absorption. However, its broader application has been constrained by the complexity of mechanochemical transformations, particularly in the …
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A study of the mechanisms of milling-induced enhancement of solubility and dissolution rate of poorly soluble drugs
Milling and co-milling are well known techniques that have potential to enhance the solubility and/or dissolution rate of poorly soluble drugs. There are broadly two aims for this project. The first was to develop an understanding of how individual and combination of techniques may be used to …
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Engineering of composite pharmaceuticals with improved physicochemical and mechanical properties
Tabletting by direct compression (DC) is the preferred method of tabletting as compared to granulation techniques because among other benefits it is simple, quick, and cost-effective. However, most pharmaceutical powders are not compressible via DC due to poor flowability, compactibility, …