Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 159 for “"Co-infection"”.
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The Consequences of Plant Anatomy on Viral Co-Infection
… vectors. Within plant hosts, viral populations encounter both physical and physiological barriers that may influence their evolution. This work aims to identify opportunities during host infection for viral populations to interact, so that it can be determined where genetic exchange events occur …
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Characterising the immunometabolic profile of HIV/TB co-infection
… the human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) during co-infection of a host is well established. While this synergy is driven by immunological deterioration, the metabolic mechanisms that contribute to the associated …
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Mechanisms of Innate Immune Dysfunction During Mycobacterium tuberculosis and HIV Co-infection
Mycobacterium tuberculosis (Mtb), the etiologic agent of Tuberculosis (TB), remains a significant public health threat causing over 1.4 million deaths annually. People living with HIV are among the most susceptible to contracting or reactivating Mtb infection due to a deterioration of essential …
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The Role of Inflammation in the Pathobiology of TB/HIV Co-infection
Mycobacterium tuberculosis (M.tb), the etiological agent of tuberculosis (TB), is the leading cause of death in people living with Human Immunodeficiency Virus (HIV). Treatment of co-infected persons is challenging due to the aggressive course of both individual diseases, and often is further …
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The Role of Inflammation in the Pathobiology of TB/HIV Co-infection
Mycobacterium tuberculosis (M.tb), the etiological agent of tuberculosis (TB), is the leading cause of death in people living with Human Immunodeficiency Virus (HIV). Treatment of co-infected persons is challenging due to the aggressive course of both individual diseases, and often is further …
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Immunoproteome of anti-TB drug associated DRESS in HIV TB co-infection
… HIV cases with DRESS (probable or definite) and confirmed reactions to either one or many first-line anti-TB (FLTB) drugs were chosen (n=8). Discovery High Performance Liquid Chromatography Mass Spectrometry (HPLC-MS) (data independent proteomic) analysis was carried out on plasma samples with …
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Characterization of Mycobacterium tuberculosis-specific Th22 cells in HIV-TB co-infection
… is hampered by multidrug resistant TB and HIV infection. There is an urgent need for an effective TB vaccine to prevent ongoing transmission. The development of a new and efficacious TB vaccine will likely be dependent on our understanding of protective immunity to TB. Although it is well …
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Clinical Implications of HIV-1, HSV-2 Co-infection and Opportunities for Intervention
HSV-2 may have adverse consequences in HIV. I evaluated the impact of HSV-2 co-infection on (highly active antiretroviral therapy)-untreated HIV infection in a systematic review of observational studies (study 1) and a retrospective cohort (study 2). I further evaluated whether HSV reactivation …
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Analysis and robust simulation of mathematical models of HIV and Leishmaniasis co-infection
… (VL) and human immunode ciency virus (HIV) coinfection. We study these models theoretically and design and analyze robust numerical methods to solve them. The rst sub-model describes the transmission dynamics of VL and incorporates three populations: the human, the reservoir, and the vector …
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Characterization of Negeviruses and insect virome interactions during co-infection in cell culture
… potential to be used as a virus-based pathogen control strategy through superinfection exclusion. Due to its recent discovery, little is known about the biology of these ISVs or how they interact with the insect’s virome. It was recently demonstrated that both wild-type and genetically modified …
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Investigating defects in monocyte responses to Mycobacterium tuberculosis in HIV-TB co-infection
Includes abstract. Includes bibliographical references.
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Development of a Humanized Mouse Model to Understand M.tb and HIV/M.tb Co-infection
Mycobacterium tuberculosis (M.tb) is the most common co-infection and leading cause of death among HIV+ individuals. Several animal models are available to study TB infection although many do not reproduce disease pathology similar to humans. The human host tropism of HIV limits its study in animal …
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Studies on CD4+ T cell subsets in Mycobacterium tuberculosis immunity during HIV co-infection
… worldwide from a single infectious agent, Mycobacterium tuberculosis (M.tb). It is estimated that a one fourth of the world's population is latently infected with TB and of these 5-10% will go on to develop active TB in their lifetime. Human immunodeficiency virus (HIV) infection is the …
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Human Immunodeficiency Virus/Human Papillomavirus co-infection and host molecular genetics of cervical carcinoma
A subgroup of women who are co-infected with human immunodeficiency virus type 1 (HIV1) and human papillomavirus (HPV) progress relatively rapidly to cervical disease regardless of the number of absolute CD4 count. During infection, viral peptides are recognized by the host immune system. It is …
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Stochastic modelling of HIV/AIDS epidemiology with TB co-infection drug reaction in South Africa
… on individuals under ART. The effects of TB co-infection, as well as the patients' development of adverse reaction to drugs to the transition rates are also examined. The study uses a cohort analysis of the surveillance data for HIV-infected patients under antiretroviral (ART) from the …
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Pathology and mechanisms of increased M.tb growth and dissemination during co-infection with HIV-1
… world’s population is latently infected with Mycobacterium tuberculosis (M.tb). M.tb and HIV have a deadly synergy that occurs during co-infection. Individuals with HIV infection are at significantly increased risk for acquiring or reactivating latent TB infections. Further, there is increased …
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Diagnostic outcomes of CT-guided lung biopsy in an HIV and TB co-infection prevalent region
… service at Groote Schuur Hospital (GSH). Secondary aims include summarising the diagnoses observed in an HIV-positive subset and comparison of diagnostic performance of different methods for TB diagnosis on biopsy samples. Method: A retrospective review of results from 406 consecutive CTLB …
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The Impact of GB Virus C co-infection on Mother to Child transmission of Human Immunodeficiency Virus
GB virus C (GBV-C) is a common, apathogenic virus that can inhibit human immunodeficiency virus (HIV) replication in vitro. Persistent coinfection with GBV-C has been associated with improved survival among HIV-infected adults while loss of GBV-C viremia has been associated with poor survival. If …
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Analysis and implementation of robust numerical methods to solve mathematical models of HIV and Malaria co-infection
… is a growing interest in the dynamics of the co-infection of these two diseases. In this thesis, firstly we focus on studying the effect of a distributed delay representing the incubation period for the malaria parasite in the mosquito vector to possibly reduce the initial transmission and …
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