Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"Co-expression network"”.
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A Context-Forward In Vivo Functional Genomics Platform For Target Discovery and Establishing Vulnerability Context In Pancreatic Cancer
… to inform on more nuanced patterns of oncogenic dependency. We hypothesized that a more comprehensive and granular characterization of PDAC disease diversity is required to establish relevant context for targeted therapy. To this end, we sought to establish an integrated platform to: i) …
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Computational Approaches to Delineate Transcriptional and Functional Heterogeneity In Pancreatic Cancer
… in <em>KRAS </em>(>90%). These tumors are highly complex ecosystems composed of molecularly distinct sub-populations that exhibit a spectrum of genetic features and associated phenotypes. Despite recent advances in the transcriptomic characterization of PDAC into at least two tumor subtypes, this …
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Defining a Neuroprotective Pathway for the Treatment of Ataxias
… the Cck1 receptor (Cck1R) in ATXN1[30Q]D776 mice confers a progressive disease where PC death occurs by thirty-six weeks of age. Weighted Gene Co-expression Network Analysis (WGCNA) performed on cerebellar RNA-seq data from ATXN1[30Q]D776;Cck-/- mice identified a disease progression-related gene …
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Transcriptomic studies of protein homeostasis perturbations in neurodegenerative disorders
Alzheimer’s Disease (AD) is the most common cause of dementia, but our understanding of its molecular origins is still incomplete. Genome-wide association studies (GWAS) have revealed key genes linked with the disease, but several more genes may need to be discovered to identify the broad range of …
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Molecular characterisation of the role of systemic infections in Alzheimer’s disease brain
… AD brain and introduces Genedex, a framework to contextualise transcriptional findings within the broader AD continuum. Using post-mortem prefrontal cortex samples from the UK Brain Bank Network, bulk RNA sequencing revealed that systemic infection elicits distinct molecular responses in AD …
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THE HOST-PATHOGEN INTERACTOME AND REGULATORY NETWORKS OF ASPERGILLUS FLAVUS PATHOGENESSIS OF ZEA MAYS: RESISTANCE IN MAIZE TO ASPERGILLUS EAR ROT AND TO AFLATOXIN ACCUMULATION
… between a pathogen and its host is a complex series of events that occurs at the molecular level and is controlled by transcriptional and protein interactions. To facilitate the understanding of these mechanisms in Aspergillus flavus and Zea mays, three approaches were taken: 1) the …
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Efficient Identification and Comprehension of Molecular Pathways Associated with Irradiation Induced Hepatic Carcinogenesis
As human exploration into deep space continues to expand in the future, risk prediction for irradiation-induced diseases will become an increasingly important task. It will be critical to identify the biological effects of high-charge, high energy (HZE) and low energy 137Cs γ rays, which are the …
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The transciptomic landscape of HIV-TB
The thesis consists of four main parts. In Part 1 of this thesis I provide a broad overview of HIVTB with an emphasis on systems approaches followed by an overview of a systems-level study aiming at addressing hypotheses relating to transcriptional differences in active tuberculosis and HIV-1 …
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Systems-Level Analysis of Rootstock–Scion Interactions in Apple Reveals Mechanisms of Cold Tolerance Under Field Frost Events
… the mechanisms underlying rootstock-dependent cold tolerance in orchard conditions remain poorly understood. In this study, we investigated frost tolerance in two apple (Malus domestica Borkh.) cultivars, 'Fuji' and 'Gala', grafted onto ten different rootstocks over the springs of 2021–2023, to …
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A multidisciplinary investigation into the function of NFXL1
… unique to our species, are essential for communication, cognitive development, and societal function. Disorders affecting these abilities are associated with learning disabilities, reduced academic achievement, and social challenges. Despite their significance, the molecular genetic basis …
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Understanding factors that affect gene co-regulation patterns
… with behavior disorders and immune system can be complex and challenging. Gene expression and network analysis can help to elucidate the main molecules and pathways that influence complex traits. The goal of these studies is to understand factors that affect gene co-regulation patterns related to …
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Understanding compound-induced histopathology in rat liver using gene expression network methods
Current drug discovery is a lengthy and costly pipeline; it takes between twelve and fifteen years and costs $1-2 billion (USD). As such, any compound failures represent a sunk cost – exacerbated if such failures occur later in the pipeline. Compound and drug induced liver injury is a significant …
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Transcriptional variation in muscle from cattle with alternative NCAPG/LCORL QTL genotypes
The NCAPG/LCORL locus is a major QTL on bovine chromosome 6 (BTA6) that influences growth and composition in cattle. Genetic variation at this locus is associated with alterations in the developmental program of individuals throughout life that may be detected through transcriptional variation. …
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Learning on the Graph: Link Prediction, Multi-label Learning, and Applications to Integrative Complex Disease Studies
<p>Most of the common human diseases, such as cancer, diabetes, and Alzheimer's disease, are consequences of the abnormality of multiple cellular components and the perturbation of their intricate interactions. The emerging network-based approaches offer a unique framework for understanding the …
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Investigating CD8+ T-cell gene expression signatures as disease prognostic biomarkers in paediatric inflammatory bowel disease.
… tailored therapy. Previous investigation of gene expression profiles from CD8+ T-cells in adult IBD cohorts identified promising signatures, including a T-cell exhaustion signature, to predict disease outcome in these patients. Hypothesis and aim: We hypothesised that adult CD8+ T-cell prognostic …
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Transcriptional regulation of glycosyltransferase genes in MCF-7 human breast cancer cell line following drug treatment
Bioinformatics is a subfield in computational science that is principally focused on developing methods and performing data analytics in the areas of proteomics and genomics. In this thesis I draw a link between proteomics and genomics by focusing on the regulation patterns of glycosyltransferase …
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Integration of bioinformatics approaches to study transcriptome patterns associated with complex traits at the gene and isoform levels
The student, Pan Zhang, accepted the attached license on 2021-03-21 at 20:12.
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Computational analysis and method development for high throughput transcriptomics and transcriptional regulatory inference in plants
… in different cell types as well as their expression analysis across various conditions. Due to its ability to provide in-depth insights into transcription and post-transcription mechanisms, RNA-seq has been extensively used in functional genetics and transcriptomics, system biology and …
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Comparative transcriptomics and co-expression networks reveal tissue- and genotype-specific responses of QDTYS to reproductive-stage drought stress in rice (Oryza sativa l.)
… rice, drought remains a major environmental constraint to rice production. While a few gene-expression profiling studies in rice in response to drought at the reproductive stage have been conducted, our knowledge of biological mechanisms in this respect is limited. Analysis tends to be …
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