Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Co-expression analysis"”.
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Understanding factors that affect gene co-regulation patterns
… with behavior disorders and immune system can be complex and challenging. Gene expression and network analysis can help to elucidate the main molecules and pathways that influence complex traits. The goal of these studies is to understand factors that affect gene co-regulation patterns related to …
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Investigating The Interaction of Aurka and Ube2C In Colorectal Cancer Cells
<p>Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the US. Among the many genomic aberrations previously implicated in colorectal cancer, recurrent amplification of chromosome 20q is frequently associated with liver metastasis. Previous research in our lab identified …
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Aggregation Pheromone Biosynthesis and Engineering in Plants for Stinkbug Pest Management
… P450 monooxygenases are involved in the conversion of these precursors to the final epoxide products. This study investigated the tissue specificity and sequence of these conversions by performing crude enzyme assays with protein extracts from male tissues. Furthermore, candidate P450 …
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Identification of novel components that connect cellulose synthases to the cytoskeleton
… parallel array, surrounding plant cells like a corset. Orientation of microfibrils determines the direction of growth by directing turgor pressure to points of expansion (Somerville et al., 2004). Hence, cellulose deficient mutants usually show cell and organ swelling due to disturbed …
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Discovery, characterization, and rational design of the enzymes involved in monoterpene indole alkaloid biosynthesis in Madagascar periwinkle
… sites to catalyze the synthesis of structurally complex compounds that serve as pharmaceuticals, insecticides, dyes, perfumes, and biofuels. In Catharanthus roseus, approximately 130 structurally complex monoterpene indole alkaloids are produced, including the clinically used anti-mitotic drugs, …
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Bioinformatics e Biostatistics applied to research in pediatric genetic disease. Clinical evidence in IFNλ4 polymorphisms associated with HCV infection in patients with beta thalassemia and WGCNA analysis weighted for IFNλ4 genotype rs12979860 to detect RPL9P18 as hub in HCV infected cell.
… by SNP rs12979860 and rs4803221 significantly could improve the viral clearance prediction in infected patients. Neither necrotic-inflammation or bilirubin values in the chronic phase of the hepatitis C were related to IFNλ4 polymorphisms. No relation among IFNλ4 polymorphisms and fibrosis …
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Annotating and characterizing orphan gene in Zea mays via diverse RNA-Seq data
… genes usually only expressed in some specific conditions. Even though many de novo genes have been evaluated in several studies from multiple RNA-Seq evidence, the limited library conditions may restrict the identification of orphan genes. Currently, we have no idea about the true number of …
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An integrated multi-omics approach to improve our understanding of ageing and neurodegeneration
The gut-brain axis is a complex system that begins its developmental journey in utero and becomes functionally activated by the first colonising microbiome at birth. In this research project, we have developed a computational framework to independently analyse single-nucleus transcriptomics and …
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Análises de redes modulares de co-expressão gênica revelam vias importantes na doença de Alzheimer e paralisia supranuclear progressiva
… diseases leading to impairment of cognitive functions and dementia have increased in recent years, mainly because of enhanced longevity in the population worldwide. Understanding the onset and progression of these pathologies can help to develop preventive and disease-modifying …
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Defining the potential of HDAC5 and HDAC9 as therapeutic targets for Parkinson’s disease
… For example, pan-HDAC inhibition by pharmacological compounds in PD models have been reported to provide some neuroprotection in PD models. However, given the number of different classes of HDACs (ClassI-IV) and their varied biological functions, it is important to evaluate the therapeutic …
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HIGH-THROUGHPUT PROFILING OF INNATE IMMUNE CELLS TO UNVEIL TUMOR ESCAPE MECHANISMS IN MATCHED COLORECTAL CANCER AND LIVER METASTASES
Colorectal cancer (CRC) represents one of the leading global health burdens, with the liver being its predominant site of distant metastasis. A significant proportion of patients with colorectal liver metastases (CRLM) are diagnosed with synchronous lesions (sCRLM), identified at or shortly after …
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A Leap of Fate: Fluid identity, functional modules, and flexible strategies for transcription factor-based reprogramming
… Direct cell reprogramming is a technique used to convert a cell from one type to another, without a stable intermediate. This is commonly achieved through transcription factor (TF) over-expression in the source cell type, with TF selection based primarily on the target cell type. Historically, …
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Machine learning enabled bioinformatics tools for analysis of biologically diverse samples
… informative biomarkers from these data becomes increasingly important. These tools are crucial to extract meaningful biomarkers from this data, especially for understanding the biological pathways responsible for disease development. The identification of signature genes and the analysis …