Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Co-encapsulation"”.
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Co-encapsulation of anti-breast cancer drugs in nanoparticles reduce antagonism
… totality of tumour treatment dictated therapy outcome and the probability of cancer remission. Differential metabolism of docetaxel (DCL) and tamoxifen (TAM), which resulted in drug antagonistic effects were shown to suppress treatment efficacy in subpopulation of cancer cells. However the …
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Investigation of cell-based therapies employing microcapsules and microspheres: encapsulation and controlled release
Microencapsulation of therapeutic cells has emerged as a major modality to treat a wide range of diseases through protecting the encapsulated cells. However, in spite of numerous refinements in cell encapsulation during the past decades, the strategy still has not met the requirements for practical …
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The delivery of bioactive proteins using biodegradable microspheres
In this project, antigen-containing microspheres were produced using a range of biodegradable polymers by single and double emulsion solvent evaporation and spray drying techniques. The proteins used in this study were mainly BSA, tetanus toxoid, F1 and V, Y. pestis subunit vaccines and the …
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Immunoisolation Approaches for Islet Transplantation
… Alginate microcapsules are the most commonly used immunoisolation device which are typically implanted intraperitoneally. Intraperitoneal microencapsulated islet grafts are suboptimal, requiring at least double the number of islets to reverse hyperglycaemia compared to …
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Elucidating the Role of Plakoglobin in Embryonic Stem Cell Culture
… developmental biology and medicine. The in vivo continuum can be separated into three in vitro states that are also found in the embryo: naïve, formative, and primed pluripotency. Embryonic stem cells are a common tool in the field, typically cultured in conventional two-dimensional cell culture. …
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Dissecting Pluripotency and Mammalian Embryonic Development via Droplet Microfluidics
… properties fundamentally different from conventional tissue culture in plastic dishes. Subsequently, I investigated how these microenvironmental changes influence pluripotency. Interestingly, microgel culture of ESCs was not just accompanied by drastic changes in morphology, but also a …
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Coaxial double-walled microspheres for drug and gene delivery applications
… double-walled microspheres were developed by coaxial electrohydrodynamic atomization (CEHDA) and precision particle fabrication (PPF) techniques. Here, we focus on double-walled microspheres consisting of a poly(D,L-lactic-co-glycolic acid) (PLGA) core surrounded by a poly(D,L-lactic acid) …
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Layer-by-Layer Nanoparticles for Targeted Delivery and Treatment of Ovarian Cancer
Ovarian cancer remains the most lethal gynecologic malignancy in the United States. Lack of early detection methods often leads to a late diagnosis and reduced survival outcomes for patients. The overwhelming majority of ovarian cancer patients are diagnosed with late stage high grade serous …