Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Co-delivery"”.
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Co-Delivery of Peptide QK and WKYMVm for Minimally Invasive Therapeutic Angiogenesis in Treating Critical Limb Ischemia
… to high rates of amputation and mortality. The delivery of therapeutic peptides emerges as a promising alternative, offering the potential to stimulate non-invasive angiogenesis at ischemic sites. However, current delivery platforms still face challenges such as burst release, incomplete …
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Dendritic cell maturation and activation via RNA/DNA danger signals : co-delivery of protein antigen with siRNA or CpG DNA
Traditional vaccines consisting of live attenuated pathogens or inactivated toxins cannot be readily applied to the more challenging diseases of the present e.g. hepatitis C and the human immunodeficiency virus. As such, there is a need to develop new methods of priming the immune system against …
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Development of a Fiberoptic Microneedle Device for Simultaneous Co-Delivery of Fluid Agents and Laser Light with Specific Applications in the Treatment of Brain and Bladder Cancers
… technology platform for fluid and light delivery, from general engineering characterization to specific applications in treating bladder and brain cancers. The central concept of the FMD is physical modification of silica fiberoptics and capillary tubes into sharp microneedles capable of …
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Drug delivery strategies to overcome ocular hypertension
Glaucoma, a group of ocular diseases that cause optic nerve damage and vision loss, is the second leading cause of irreversible blindness worldwide. Current treatments, primarily eye drops, require frequent administration due to natural tear fluid turnover and blinking, which reduces patient …
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Co-encapsulation of anti-breast cancer drugs in nanoparticles reduce antagonism
… totality of tumour treatment dictated therapy outcome and the probability of cancer remission. Differential metabolism of docetaxel (DCL) and tamoxifen (TAM), which resulted in drug antagonistic effects were shown to suppress treatment efficacy in subpopulation of cancer cells. However the …
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SIRT1 ACTIVATION IMPROVES HEART FUNCTION THROUGH INHIBITION OF INFLAMMATION IN CHAGAS DISEASE
… in chagasic mice. SIRT1 agonist, however, controlled the NFB signaling of oxidative and inflammatory responses and helped preserve the left ventricular function in chagasic mice. We also found that SRT1720 decreased the proinflammatory differentiation of macrophages in spleen and heart …
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Design and Validation of Medical Devices for Photothermally Augmented Treatments
… is assumed to be spherical and isotropic with constant flow rate and concentration. The Peclet numberdecreases with power function Pe = 15762t0.337 due to the decrease in mean dye-front pore velocity as V goes to Vfinal. Diffusive mass transport does not become significant during any relevent …
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Probabilistic Multi-Compartment Deformable Model, Application to Cell Segmentation
A crucial task in computer vision and biomedical image applications is to represent images in a numerically compact form for understanding, evaluating and/or mining their content. The fundamental step of this task is the segmentation of images into regions, given some homogeneity criteria, prior …
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Development of a Hollow-Core Fiberoptic Microneedle Device for the Treatment of Invasive Bladder Cancer
… chronicles the early development of the hollow-core fiberoptic microneedle device (FMD). The study determined that for straight tubing with an inner bore of 150 ?m and a length greater than 50 mm long, Poiseuille's Law was shown to be accurate within 12% of experimental data for the pressure …
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OPTIMIZING GENE THERAPY: THE IMPACT OF SMALL MOLECULE MODULATORS ON ADENO-ASSOCIATED VECTOR TRANSDUCTION AND INTEGRATION
… virus (AAV) is a widely used vehicle for gene delivery but a limitation to AAV gene therapy can be inefficient transgene expression from AAV vectors. One approach to improve AAV transduction has been to combine the vector with small molecule modulators that disrupt cellular pathways, which can …
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Carbon Monoxide Prodrugs for Targeted Cancer Therapy
Carbon monoxide (CO) is endogenously produced in the body through the breakdown of haem by haem oxygenase enzymes. Since this discovery, CO has been recognised as a gasotransmitter alongside nitric oxide and hydrogen sulfide. Beyond established physiological roles, CO has shown therapeutic …
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Factors that Affect the Immunogenicity of Lipid-PLGA Nanoparticle-Based Nanovaccines against Nicotine Addiction
Tobacco smoking has consistently been the leading cause of preventable diseases and premature deaths. Currently, pharmacological interventions have only shown limited smoking cessation efficacy and sometimes are associated with severe side effects. As an alternative, nicotine vaccines have emerged …
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Managing risks in energy capital projects -- the value of contractual risk-sharing in CCS-EOR
… can be categorized as exogenous risks (not in control of involved entities) and endogenous risks (arising from sub-optimal decisions by involved entities). A dominant reason for poor project performance is the endogenous risks associated with weak incentives to deliver optimal project outcomes. …
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Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis
… 3, we developed a poly(ethyleneimine) (PEI) conjugated biodegradable multiblock polymer to form nanocomplexes with VEGF siRNA for TNBC treatment. The nanocomplex is able to deliver the VEGF siRNA into TNBC cells with a high transfection efficiency and low cytotoxicity. In vitro activity …
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Development of Novel Therapeutic Strategies for Pancreatic Cancer Treatment
… 5-FU, Nab-paclitaxel and, FOLFIRINOX alone or in combination, have displayed improved but marginal survival rates for patients. Therefore, research efforts are underway to discover new therapeutic options to treat PanCa and overcome resistance to available therapies.</p> <p>Mucin, MUC13 is …